To the editorBetween the end of 2020 and the beginning of 2021, the first mRNA vaccines against COVID-19 received approval for emergency use by the World Health Organization (WHO). Patientsaffected by fibrotic interstitial lung disease (ILD) were granted priority access to vaccination,as these patients may develop severe complications after SARS-CoV-2 infection and carry ahigher risk… Continue reading COVID-19 Vaccine in Patients with Exacerbation of Idiopathic Pulmonary Fibrosis
Category: Pneumology
KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer
EP300, a transcription coactivator important in proliferation and differentiation, is frequently mutated in diverse cancer types, including small cell lung cancer (SCLC). While these mutations are thought to result in loss of EP300 function, the impact on tumorigenesis remains largely unknown. Here, we demonstrate that EP300 mutants lacking acetyltransferase domain accelerate tumor development in mouse… Continue reading KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer
Detection of microplastics in human lung tissue using μFTIR spectroscopy
AbstractAirborne microplastics (MPs) have been sampled globally, and their concentration is known to increase in areas of high human population and activity, especially indoors. Respiratory symptoms and disease following exposure to occupational levels of MPs within industry settings have also been reported. It remains to be seen whether MPs from the environment can be inhaled,… Continue reading Detection of microplastics in human lung tissue using μFTIR spectroscopy
Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip
AbstractMechanical breathing motions have a fundamental function in lung development and disease, but little is known about how they contribute to host innate immunity. Here we use a human lung alveolus chip that experiences cyclic breathing-like deformations to investigate whether physical forces influence innate immune responses to viral infection. Influenza H3N2 infection of mechanically active… Continue reading Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip
Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in ChildrenThe SCOUT-CAP Randomized Clinical Trial
Childhood community-acquired pneumonia (CAP) is usually treated with 10 days of antibiotics. Shorter courses may be effective with fewer adverse effects and decreased potential for antibiotic resistance. Objective To compare a short (5-day) vs standard (10-day) antibiotic treatment strategy for CAP in young children. Design, Setting, and Participants Randomized double-blind placebo-controlled clinical trial in outpatient… Continue reading Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in ChildrenThe SCOUT-CAP Randomized Clinical Trial
Neutrophil-to-Lymphocyte Ratio Better Than High-Sensitivity C-Reactive Protein in Predicting Stroke-Associated Pneumonia in Afebrile Patients
To evaluate the association between neutrophil-to-lymphocyte ratio (NLR) and stroke-associated pneumonia (SAP) in patients with acute ischemic stroke (AIS) without fever and to clarify whether NLR has an advantage over high-sensitivity C-reactive protein (hs-CRP) in predicting SAP. Patients and Methods: A total of 434 patients with AIS without fever were assessed in this study. Multivariable… Continue reading Neutrophil-to-Lymphocyte Ratio Better Than High-Sensitivity C-Reactive Protein in Predicting Stroke-Associated Pneumonia in Afebrile Patients
Obstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program
Although there is a strong association between obesity and obstructive sleep apnoea (OSA), the effects of OSA and CPAP therapy on weight loss are less well known. The aim of this study in adults with class 3 obesity attending a multidisciplinary weight management program was to assess the relationship between OSA and CPAP usage, and… Continue reading Obstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program
SARS–CoV–2 #Spike Impairs #DNA Damage Repair and InhibitsV(D)J Recombination In Vitro
Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy.Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly in-fluences the clinical outcomes of patients. Clinical studies have indicated that patients with severeCOVID–19 exhibit delayed and weak adaptive… Continue reading SARS–CoV–2 #Spike Impairs #DNA Damage Repair and InhibitsV(D)J Recombination In Vitro
#Zinc for the prevention or treatment of acute viral #respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials
To evaluate the benefits and risks of zinc formulations compared with controls for prevention or treatment of acute viral respiratory tract infections (RTIs) in adults. Method Seventeen English and Chinese databases were searched in April/May 2020 for randomised controlled trials (RCTs), and from April/May 2020 to August 2020 for SARS-CoV-2 RCTs. Cochrane rapid review methods… Continue reading #Zinc for the prevention or treatment of acute viral #respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials
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