Electronic-cigarettes (E-cigs) are marketed as a safe alternative to tobacco to deliver the stimulant nicotine, and their use is gaining in popularity, particularly among the younger population. We recently showed that mice exposed to short-term (12 wk) E-cig smoke (ECS) sustained extensive DNA damage in lungs, heart, and bladder mucosa and diminished DNA repair in… Continue reading Electronic-#cigarette smoke induces #lung adenocarcinoma and #bladder urothelial hyperplasia in mice
Category: Pneumology
#C-reactive protein mediates the association between leisure-time physical #activity and #lung function in middle-aged and older adults
Although previous studies have reported the benefits of physical activity (PA) to lung function in middle-aged and older adults, the biological mechanisms are still unclear.. ..Multiple linear regression models suggested that higher PA was associated with lower levels of CRP (β = − 0.048, P = 0.002 for moderate PA; β = − 0.108, P < 0.001 for high PA). CRP negatively correlated with FEV1… Continue reading #C-reactive protein mediates the association between leisure-time physical #activity and #lung function in middle-aged and older adults
Characteristics of Patients Experiencing Rehospitalization or Death After Hospital Discharge in a Nationwide Outbreak of #E-cigarette, or #Vaping, Product Use–Associated Lung Injury — United States, 2019
Some patients hospitalized for e-cigarette, or vaping, product use–associated lung injury (EVALI) have been rehospitalized or have died after hospital discharge.. ..Compared with other EVALI patients, rehospitalized patients and patients who died after hospital discharge were more likely to have one or more chronic conditions, including cardiac disease, chronic pulmonary disease, and diabetes, and to… Continue reading Characteristics of Patients Experiencing Rehospitalization or Death After Hospital Discharge in a Nationwide Outbreak of #E-cigarette, or #Vaping, Product Use–Associated Lung Injury — United States, 2019
Neurontin, Gralise, Horizant (#gabapentin) and Lyrica, Lyrica CR (#pregabalin): Drug Safety Communication – Serious Breathing Problems
..FDA is warning that serious breathing difficulties may occur in patients using gabapentin (Neurontin, Gralise, Horizant) or pregabalin (Lyrica, Lyrica CR) who have respiratory risk factors. These include the use of opioid pain medicines and other drugs that depress the central nervous system, and conditions such as chronic obstructive pulmonary disease that reduce lung function.… Continue reading Neurontin, Gralise, Horizant (#gabapentin) and Lyrica, Lyrica CR (#pregabalin): Drug Safety Communication – Serious Breathing Problems
Safety and efficacy of high-dose unfractionated #heparin versus high-dose enoxaparin for venous #thromboembolism prevention in morbidly obese hospitalized patients
..A single-center retrospective observational study was conducted in morbidly obese (body mass index ≥ 40 kg/m2) hospitalized patients who received either high-fixed dose enoxaparin (40 mg every 12 hours) or unfractionated heparin (7,500 units every 8 hours) for venous thromboembolism prophylaxis. ..In the 305 patients included (n=190 unfractionated heparin, n=115 enoxaparin), the incidence of major… Continue reading Safety and efficacy of high-dose unfractionated #heparin versus high-dose enoxaparin for venous #thromboembolism prevention in morbidly obese hospitalized patients
Association of Long-term Ambient #Ozone Exposure With Respiratory Morbidity in #Smokers
..In adjusted analysis, a 5-ppb (parts per billion) increase in ozone concentration was associated with a greater percentage of emphysema (β = 0.94; 95% CI, 0.25-1.64; P = .007) and percentage of air trapping (β = 1.60; 95% CI, 0.16-3.04; P = .03); worse scores for the mMRC Dyspnea Scale (β = 0.10; 95% CI, 0.03-0.17; P = .008), CAT (β = 0.65; 95% CI, 0.05-1.26; P = .04), and SGRQ… Continue reading Association of Long-term Ambient #Ozone Exposure With Respiratory Morbidity in #Smokers
Prediction model for #pneumonia in primary care patients with an acute respiratory tract infection: role of symptoms, signs, and biomarkers
Diagnosing pneumonia can be challenging in general practice but is essential to distinguish from other respiratory tract infections because of treatment choice and outcome prediction.. ..Two hundred forty-nine patients were included of whom 30 (12%) displayed a consolidation on chest X ray. Absence of runny nose and whether or not a patient felt ill were… Continue reading Prediction model for #pneumonia in primary care patients with an acute respiratory tract infection: role of symptoms, signs, and biomarkers
Effectiveness of a Brief Self-determination Theory–Based Smoking Cessation Intervention for Smokers at Emergency Departments in Hong Kong
Clinicians have an opportunity to provide #smoking cessation interventions to smokers who present to emergency departments (EDs). The effectiveness of a brief intervention based on self-determination theory for smoking cessation is uncertain. ..The intervention group received brief advice (about 1 minute) and could choose their own quit schedules (immediate or progressive) ..Compared with the control… Continue reading Effectiveness of a Brief Self-determination Theory–Based Smoking Cessation Intervention for Smokers at Emergency Departments in Hong Kong
Diagnosis of Pulmonary #Embolism with d-#Dimer Adjusted to Clinical Probability
Retrospective analyses suggest that pulmonary embolism is ruled out by a d-dimer level of less than 1000 ng per milliliter in patients with a low clinical pretest probability (C-PTP) and by a d-dimer level of less than 500 ng per milliliter in patients with a moderate C-PTP ..We performed a prospective study in which pulmonary… Continue reading Diagnosis of Pulmonary #Embolism with d-#Dimer Adjusted to Clinical Probability
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