Some patients hospitalized for e-cigarette, or vaping, product use–associated lung injury (EVALI) have been rehospitalized or have died after hospital discharge.. ..Compared with other EVALI patients, rehospitalized patients and patients who died after hospital discharge were more likely to have one or more chronic conditions, including cardiac disease, chronic pulmonary disease, and diabetes, and to… Continue reading Characteristics of Patients Experiencing Rehospitalization or Death After Hospital Discharge in a Nationwide Outbreak of #E-cigarette, or #Vaping, Product Use–Associated Lung Injury — United States, 2019
Category: Pneumology
Neurontin, Gralise, Horizant (#gabapentin) and Lyrica, Lyrica CR (#pregabalin): Drug Safety Communication – Serious Breathing Problems
..FDA is warning that serious breathing difficulties may occur in patients using gabapentin (Neurontin, Gralise, Horizant) or pregabalin (Lyrica, Lyrica CR) who have respiratory risk factors. These include the use of opioid pain medicines and other drugs that depress the central nervous system, and conditions such as chronic obstructive pulmonary disease that reduce lung function.… Continue reading Neurontin, Gralise, Horizant (#gabapentin) and Lyrica, Lyrica CR (#pregabalin): Drug Safety Communication – Serious Breathing Problems
Safety and efficacy of high-dose unfractionated #heparin versus high-dose enoxaparin for venous #thromboembolism prevention in morbidly obese hospitalized patients
..A single-center retrospective observational study was conducted in morbidly obese (body mass index ≥ 40 kg/m2) hospitalized patients who received either high-fixed dose enoxaparin (40 mg every 12 hours) or unfractionated heparin (7,500 units every 8 hours) for venous thromboembolism prophylaxis. ..In the 305 patients included (n=190 unfractionated heparin, n=115 enoxaparin), the incidence of major… Continue reading Safety and efficacy of high-dose unfractionated #heparin versus high-dose enoxaparin for venous #thromboembolism prevention in morbidly obese hospitalized patients
Association of Long-term Ambient #Ozone Exposure With Respiratory Morbidity in #Smokers
..In adjusted analysis, a 5-ppb (parts per billion) increase in ozone concentration was associated with a greater percentage of emphysema (β = 0.94; 95% CI, 0.25-1.64; P = .007) and percentage of air trapping (β = 1.60; 95% CI, 0.16-3.04; P = .03); worse scores for the mMRC Dyspnea Scale (β = 0.10; 95% CI, 0.03-0.17; P = .008), CAT (β = 0.65; 95% CI, 0.05-1.26; P = .04), and SGRQ… Continue reading Association of Long-term Ambient #Ozone Exposure With Respiratory Morbidity in #Smokers
Prediction model for #pneumonia in primary care patients with an acute respiratory tract infection: role of symptoms, signs, and biomarkers
Diagnosing pneumonia can be challenging in general practice but is essential to distinguish from other respiratory tract infections because of treatment choice and outcome prediction.. ..Two hundred forty-nine patients were included of whom 30 (12%) displayed a consolidation on chest X ray. Absence of runny nose and whether or not a patient felt ill were… Continue reading Prediction model for #pneumonia in primary care patients with an acute respiratory tract infection: role of symptoms, signs, and biomarkers
Effectiveness of a Brief Self-determination Theory–Based Smoking Cessation Intervention for Smokers at Emergency Departments in Hong Kong
Clinicians have an opportunity to provide #smoking cessation interventions to smokers who present to emergency departments (EDs). The effectiveness of a brief intervention based on self-determination theory for smoking cessation is uncertain. ..The intervention group received brief advice (about 1 minute) and could choose their own quit schedules (immediate or progressive) ..Compared with the control… Continue reading Effectiveness of a Brief Self-determination Theory–Based Smoking Cessation Intervention for Smokers at Emergency Departments in Hong Kong
Diagnosis of Pulmonary #Embolism with d-#Dimer Adjusted to Clinical Probability
Retrospective analyses suggest that pulmonary embolism is ruled out by a d-dimer level of less than 1000 ng per milliliter in patients with a low clinical pretest probability (C-PTP) and by a d-dimer level of less than 500 ng per milliliter in patients with a moderate C-PTP ..We performed a prospective study in which pulmonary… Continue reading Diagnosis of Pulmonary #Embolism with d-#Dimer Adjusted to Clinical Probability
Underuse of Clinical Decision Rules and d-#Dimer in Suspected Pulmonary #Embolism: A Nationwide Survey of the Veterans Administration Health Care System
The diagnosis of pulmonary embolism (PE) remains a challenge. CT pulmonary angiography (CTPA) for suspected PE has become the primary imaging modality, but concerns regarding overutilization, overdiagnosis, radiation, and costs have led to algorithms that combine a clinical decision rule (CDR) and highly sensitive d-dimer to identify patients in whom PE can be safely excluded… Continue reading Underuse of Clinical Decision Rules and d-#Dimer in Suspected Pulmonary #Embolism: A Nationwide Survey of the Veterans Administration Health Care System
Comparisons of exacerbations and mortality among regular inhaled therapies for patients with stable chronic obstructive pulmonary disease: Systematic review and Bayesian network meta-analysis
..Compared with placebo, all drug classes significantly reduced the total exacerbations and moderate to severe exacerbations. ICS/LAMA/LABA was the most efficacious treatment for reducing the exacerbation risk (odds ratio [OR] = 0.57; 95% credible interval [CrI] 0.50–0.64; posterior probability of OR > 1 [P(OR > 1)] < 0.001). In addition, in contrast to the other… Continue reading Comparisons of exacerbations and mortality among regular inhaled therapies for patients with stable chronic obstructive pulmonary disease: Systematic review and Bayesian network meta-analysis
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