..Our goal was to examine the association between playing games and change in cognitive function from age 11 to age 70, and from age 70 to 79.. Higher frequency of playing games was associated with higher cognitive function at age 70, controlling for age 11 cognitive function, and the majority of this association could not… Continue reading Playing analog #games is associated with reduced declines in #cognitive function: a 68 year longitudinal cohort study
Category: Neurology
#Illiteracy, #dementia risk, and cognitive trajectories among older adults with low education
..Analyses included 983 adults (≥65 years old, ≤4 years of schooling) who participated in a longitudinal community aging study. Literacy was self-reported (“Did you ever learn to read or write?”).. ..Illiterate participants were almost 3 times as likely to have dementia at baseline compared to literate participants. Among those who did not have dementia at… Continue reading #Illiteracy, #dementia risk, and cognitive trajectories among older adults with low education
#Particulate matter and episodic #memory decline mediated by early neuroanatomic biomarkers of Alzheimer’s disease
Evidence suggests exposure to particulate matter with aerodynamic diameter <2.5 μm (PM2.5) may increase the risk for Alzheimer’s disease and related dementias.. ..Long-term PM2.5 exposure was associated with increased Alzheimer’s disease pattern similarity scores, which accounted for 22.6% (95% CI: 1% to 68.9%) and 10.7% (95% CI: 1.0% to 30.3%) of the total adverse PM2.5… Continue reading #Particulate matter and episodic #memory decline mediated by early neuroanatomic biomarkers of Alzheimer’s disease
Bedside #Optic Nerve Ultrasonography for Diagnosing Increased Intracranial #pressure: A Systematic Review and Meta-analysis
Optic nerve ultrasonography (optic nerve sheath diameter sonography) has been proposed as a noninvasive, quick method for diagnosing increased intracranial pressure ..Accuracy estimates were similar among studies stratified by patient age, operator specialty and training level, reference standard, sonographer blinding status, and cutoff value. The optimal cutoff for optic nerve sheath dilatation on ultrasonography was… Continue reading Bedside #Optic Nerve Ultrasonography for Diagnosing Increased Intracranial #pressure: A Systematic Review and Meta-analysis
Effect of Standard vs Intensive Blood #Pressure Control on the Risk of Recurrent #Stroke
The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated that a systolic blood pressure (BP) target less than 120 mm Hg was superior to less than 140 mm Hg for preventing vascular events. This trial excluded patients with prior stroke; therefore, the ideal BP target for secondary stroke prevention remains unknown. ..Throughout the overall follow-up period,… Continue reading Effect of Standard vs Intensive Blood #Pressure Control on the Risk of Recurrent #Stroke
#Aspirin for primary #prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups
..major adverse cardiovascular events (MACE) ..Aspirin use did not translate into a net clinical benefit adjusted for event-associated mortality risk (mean 0.034%; 95% CI, − 0.18 to 0.25%). There was an interaction for aspirin effect in three patient subgroups: (i) in patients under statin treatment, aspirin was associated with a 12% RRR of MACE (RR 0.88;… Continue reading #Aspirin for primary #prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups
In Vivo Assessment of #Retinal Biomarkers by Hyperspectral Imaging: Early Detection of #Alzheimer’s Disease
..The retina is a developmental extension of the brain and has been viewed as a window to evaluate AD-related pathology. ..Described herein is the utilization of our retinal hyperspectral imaging (rHSI) technique as a biomarker for identification of AD-related early pathological changes in the retina The underlying principle is Rayleigh light scattering, which is expected… Continue reading In Vivo Assessment of #Retinal Biomarkers by Hyperspectral Imaging: Early Detection of #Alzheimer’s Disease
#Nanoparticle-induced #neutrophil apoptosis increases survival in #sepsis and alleviates neurological damage in #stroke
Human neutrophils are the most abundant circulating leukocytes and contribute to acute and chronic inflammatory disorders. Neutrophil apoptosis is programed cell death to maintain immune homeostasis, but inflammatory responses to infections or tissue injury disrupt neutrophil death program, leading to many diseases. Precise control of neutrophil apoptosis may resolve inflammation to return immune homeostasis. Here,… Continue reading #Nanoparticle-induced #neutrophil apoptosis increases survival in #sepsis and alleviates neurological damage in #stroke
Associations Between #vascular Risk Across Adulthood and #Brain Pathology in Late Life Evidence From a British Birth Cohort
Office-based Framingham Heart study–cardiovascular risk scores (FHS-CVS) were derived at ages 36, 53, and 69 years using systolic blood pressure, antihypertensive medication usage, smoking, diabetic status, and body mass index. Analysis models adjusted for age at imaging, sex, APOE genotype, socioeconomic position, and, where appropriate, total intracranial volume. ..At all points, these scores were associated… Continue reading Associations Between #vascular Risk Across Adulthood and #Brain Pathology in Late Life Evidence From a British Birth Cohort
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