A new syndrome of vaccine-induced immune thrombotic thrombocytopenia (VITT) has emerged as a rare side-effect of vaccination against COVID-19. Cerebral venous thrombosis is the most common manifestation of this syndrome but, to our knowledge, has not previously been described in detail. We aimed to document the features of post-vaccination cerebral venous thrombosis with and without… Continue reading #Cerebral venous #thrombosis after vaccination against #COVID-19 in the UK: a multicentre cohort study
Category: Neurology
Greater Adherence to Secondary Prevention Medications Improves Survival After #Stroke or Transient #Ischemic Attack: A Linked Registry Study
Although a target of 80% medication adherence is commonly cited, it is unclear whether greater adherence improves survival after stroke or transient ischemic attack (TIA). We investigated associations between medication adherence during the first year postdischarge, and mortality up to 3 years, to provide evidence-based targets for medication adherence. Methods:Retrospective cohort study of 1-year survivors… Continue reading Greater Adherence to Secondary Prevention Medications Improves Survival After #Stroke or Transient #Ischemic Attack: A Linked Registry Study
Reinforcement learning links spontaneous cortical #dopamine impulses to reward
Extrasynaptic levels of dopamine in mouse cortex exhibit spontaneous impulses•Impulses are broadly distributed in amplitude and time, with a rate of about 0.01/s•Feedback was used to train mice to volitionally control their spontaneous impulses•Mice learned to reliably modulate dopamine impulses in order to receive a reward SummaryIn their pioneering study on dopamine release, Romo and… Continue reading Reinforcement learning links spontaneous cortical #dopamine impulses to reward
Long-term Dietary #Flavonoid Intake and Subjective #Cognitive Decline in US Men and Women
To prospectively examine the associations between long-term dietary flavonoids and subjective cognitive decline (SCD). Methods: We followed 49,493 women from the Nurses’ Health Study (NHS) (1984-2006) and 27,842 men from the Health Professionals Follow-up Study (HPFS) (1986-2002). Poisson regression was used to evaluate the associations between dietary flavonoids (flavonols, flavones, flavanones, flavan-3-ols, anthocyanins, polymeric flavonoids,… Continue reading Long-term Dietary #Flavonoid Intake and Subjective #Cognitive Decline in US Men and Women
Distribution of dietary #protein intake in daily meals influences skeletal #muscle hypertrophy via the muscle clock
Distribution of dietary protein across meals influences muscle hypertrophy•BCAAs are involved in hypertrophic effects of protein feeding distribution•Hypertrophic effects of protein feeding distribution require the muscle clock•Breakfast protein intake is correlated with skeletal muscle functions in older women SummaryThe meal distribution of proteins throughout the day is usually skewed. However, its physiological implications and the… Continue reading Distribution of dietary #protein intake in daily meals influences skeletal #muscle hypertrophy via the muscle clock
Associations of #overweight and #obesity with drug-resistant #epilepsy
The group with epilepsy included in this study had a lower proportion of individuals with overweight and obesity than the general population (23.1% versus 42%) in 2015. However, the proportion of patients with obesity in the groups with DRE was significantly higher than that in the general population (17.9% versus 7.1%).•The J-shaped relationship between BMI… Continue reading Associations of #overweight and #obesity with drug-resistant #epilepsy
Association of Oral #Anticoagulation With #Stroke in Atrial #Fibrillation or Heart #Failure: A Comparative Meta-Analysis
Atrial fibrillation and heart failure with reduced ejection fraction (HFrEF) are common sources of cardioembolism. While oral anticoagulation is strongly recommended for atrial fibrillation, there are marked variations in guideline recommendations for HFrEF due to uncertainty about net clinical benefit. This systematic review and meta-analysis evaluates the comparative association of oral anticoagulation with stroke and… Continue reading Association of Oral #Anticoagulation With #Stroke in Atrial #Fibrillation or Heart #Failure: A Comparative Meta-Analysis
The #CHA2DS2-VASc Score for Risk Stratification of #Stroke in Heart Failure With-vs-Without Atrial #Fibrillation
A recent study suggested that the CHA2DS2-VASc score can risk stratify heart failure (HF) patients without atrial fibrillation (AF) for stroke. We performed a retrospective analysis using the national Veteran Affairs database to externally validate the findings. Crude incidence rates of end points were calculated. A Cox proportional model was used to study the association… Continue reading The #CHA2DS2-VASc Score for Risk Stratification of #Stroke in Heart Failure With-vs-Without Atrial #Fibrillation
Guiding principles for determining work #shift duration and addressing the effects of work shift duration on performance, safety, and health: guidance from the American Academy of #Sleep Medicine and the Sleep Research Society
Risks associated with fatigue that accumulates during work shifts have historically been managed through working time arrangements that specify fixed maximum durations of work shifts and minimum durations of time off. By themselves, such arrangements are not sufficient to curb risks to performance, safety, and health caused by misalignment between work schedules and the biological… Continue reading Guiding principles for determining work #shift duration and addressing the effects of work shift duration on performance, safety, and health: guidance from the American Academy of #Sleep Medicine and the Sleep Research Society
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