Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination

Multiple sclerosis (MS) is the most prevalent autoimmune disease of the central nervous system (CNS), leading to irreversible deficits in young adults. Its pathophysiology is believed to be influenced by environmental determinants. As far back as the 1990s, it had been suggested that there is a correlation between the consumption of cow’s milk and the …

Continue reading Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination

Association Between Time Spent Outdoors and Risk of Multiple Sclerosis

This study aims to determine the contributions of sun exposure and ultraviolet radiation (UVR) exposure to risk of paediatric-onset multiple sclerosis (MS). Methods: Children with MS and controls recruited from multiple centres in the USA were matched on sex and age. Multivariable conditional logistic regression was used to investigate the association of time spent outdoors …

Continue reading Association Between Time Spent Outdoors and Risk of Multiple Sclerosis

Transcriptomic and clonal characterization of #T cells in the human central #nervous system

T cells provide critical immune surveillance to the central nervous system (CNS), and the cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further characterization of the state of T cells in the CSF in healthy individuals is important for understanding how T cells provide protective immune surveillance without damaging the …

Continue reading Transcriptomic and clonal characterization of #T cells in the human central #nervous system