Down syndrome (DS) is the most common form of chromosomal trisomy. Genetic factors in DS may increase the risk for diabetes. This study aimed to determine whether DS is associated with an increased incidence of diabetes and the relationship with obesity across the life span compared with control patients.RESEARCH DESIGN AND METHODSThis matched population–based cohort… Continue reading Diabetes and Obesity in Down Syndrome Across the Lifespan: A Retrospective Cohort Study Using U.K. Electronic Health Records
Category: Neurology
Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index
Recent genome-wide association studies corroborate classical research on developmental programming indicating that obesity is primarily a neurodevelopmental disease strongly influenced by nutrition during critical ontogenic windows. Epigenetic mechanisms regulate neurodevelopment; however, little is known about their role in establishing and maintaining the brain’s energy balance circuitry. We generated neuron and glia methylomes and transcriptomes from… Continue reading Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index
Motion, Relation, and Passion in Brain Physiological and Cognitive Aging
Abstract: The aim of the current paper was to present important factors for keeping the basic structures of a person’s brain function, i.e., the grey and white matter, intact. Several lines of evidence have shown that motion, relation, and passion are central factors for preserving the neural system in the grey and white matter during… Continue reading Motion, Relation, and Passion in Brain Physiological and Cognitive Aging
Associations of sleep timing and time in bed with dementia and cognitive decline among Chinese older adults: A cohort study
Background: The longitudinal associations of sleep timing and time in bed (TIB) with dementia and cognitive decline in older adults are unclear. Methods: This population-based cohort study used data from 1982 participants who were aged ≥60 years, free of dementia, and living in rural communities in western Shandong, China. At the baseline (2014) and follow-up… Continue reading Associations of sleep timing and time in bed with dementia and cognitive decline among Chinese older adults: A cohort study
Temporal patterns of energy intake and cognitive function and its decline: a community-based cohort study in China
Dear Editor,Worldwide, around 55 million people had prevalent dementia in 2019, which is expected to triple by 2050, especially in low- and middle-income countries. Lacking timely diagnosis and limited effective treatment for dementia make identifying risk factors crucial for its early prevention, among which dietary factors have received increasing attention.Recently, accumulating evidence from population-based studies… Continue reading Temporal patterns of energy intake and cognitive function and its decline: a community-based cohort study in China
Association of Combined Healthy Lifestyle Factors With Incident Dementia in Patients With Type 2 Diabetes
Background and Objectives: Type 2 diabetes and lifestyle factors have been associated with dementia risk, but the impact of a healthy lifestyle on diabetes-related dementia remains largely unknown. We aimed to investigate whether the increased risk of dementia among individuals with diabetes can be offset by a broad combination of healthy lifestyle factors.Methods: This prospective study utilized… Continue reading Association of Combined Healthy Lifestyle Factors With Incident Dementia in Patients With Type 2 Diabetes
Fitness tracking reveals task-specific associations between memory, mental health, and physical activity
Physical activity can benefit both physical and mental well-being. Different forms of exercise (e.g., aerobic versus anaerobic; running versus walking, swimming, or yoga; high-intensity interval training versus endurance workouts; etc.) impact physical fitness in different ways. For example, running may substantially impact leg and heart strength but only moderately impact arm strength. We hypothesized that… Continue reading Fitness tracking reveals task-specific associations between memory, mental health, and physical activity
Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial
IntroductionDietary supplements are touted for cognitive protection, but supporting evidence is mixed. COSMOS-Mind tested whether daily administration of cocoa extract (containing 500 mg/day flavanols) versus placebo and a commercial multivitamin-mineral (MVM) versus placebo improved cognition in older women and men.MethodsCOSMOS-Mind, a large randomized two-by-two factorial 3-year trial, assessed cognition by telephone at baseline and annually. The… Continue reading Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial
Periodontal health, cognitive decline, and dementia: A systematic review and meta-analysis of longitudinal studies
AbstractBackgroundEmerging evidence indicates that poor periodontal health adversely impacts cognition. This review examined the available longitudinal evidence concerning the effect of poor periodontal health on cognitive decline and dementia.MethodsComprehensive literature search was conducted on five electronic databases for relevant studies published until April 2022. Longitudinal studies having periodontal health as exposure and cognitive decline and/or… Continue reading Periodontal health, cognitive decline, and dementia: A systematic review and meta-analysis of longitudinal studies
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