Further restrictions on use; pregnancy prevention programme to be put in placeEMA’s safety committee (PRAC) recommends new measures to avoid exposure of children to topiramate-containing medicines in the womb, because the medicine may increase the risk of neurodevelopmental problems after exposure during pregnancy. Topiramate is already known to cause serious birth defects when used during… Continue reading PRAC recommends new measures to avoid #topiramate exposure in #pregnancy
Category: Neurology
Deep Brain Stimulation: A Revolutionary Approach to Post-Stroke Rehabilitation
In recent years, the medical community has concentrated its efforts on developing innovative treatments to aid in post-stroke recovery. Among the … Deep Brain Stimulation: A Revolutionary Approach to Post-Stroke RehabilitationDeep Brain Stimulation: A Revolutionary Approach to Post-Stroke Rehabilitation
How Important is your SLEEP CYCLE!
Sleep Cycle is something that has taken a back seat in the current era. Sleep is an essential NEED to the human body just like food. And here we are not talking about sleeping in excess, we are talking about the regular 7 hour sleep cycle that acts like a key to your brain. Hello… Continue reading How Important is your SLEEP CYCLE!
Irisin reduces #amyloid-β by inducing the release of neprilysin from #astrocytes following downregulation of ERK-STAT3 signaling
A pathological hallmark of Alzheimer’s disease (AD) is the deposition of amyloid-β (Aβ) protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD mouse models, but the underlying mechanisms have not been elucidated. Irisin, an exercise-induced hormone, is the secreted form of fibronectin type-III-domain-containing 5 (FNDC5). Here, using a… Continue reading Irisin reduces #amyloid-β by inducing the release of neprilysin from #astrocytes following downregulation of ERK-STAT3 signaling
Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals
AbstractAbdominal fat is increasingly linked to brain health. A total of 10,001 healthy participants were scanned on 1.5T MRI with a short whole-body MR imaging protocol. Deep learning with FastSurfer segmented 96 brain regions. Separate models segmented visceral and subcutaneous abdominal fat. Regression analyses of abdominal fat types and normalized brain volumes were evaluated, controlling… Continue reading Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals
The Gut-Brain Axis: Unveiling the Microbiome’s Role in Cognitive Development and Brain Health
A Complex Communication Highway In the intricate network of the human body, a fascinating unsuspected connection is being unraveled—one that links the gut and the brain in ways we never imagined! This connection, known as the Gut-Brain Axis, is revealing a whole new dimension to the critical role played by the microbiome in the development… Continue reading The Gut-Brain Axis: Unveiling the Microbiome’s Role in Cognitive Development and Brain Health
Effect of apolipoprotein genotype and #educational attainment on #cognitive function in autosomal dominant #Alzheimer’s disease
Autosomal dominant Alzheimer’s disease (ADAD) is genetically determined, but variability in age of symptom onset suggests additional factors may influence cognitive trajectories. Although apolipoprotein E (APOE) genotype and educational attainment both influence dementia onset in sporadic AD, evidence for these effects in ADAD is limited. To investigate the effects of APOE and educational attainment on age-related cognitive… Continue reading Effect of apolipoprotein genotype and #educational attainment on #cognitive function in autosomal dominant #Alzheimer’s disease
Effects of adult #education on #cognitive function and risk of #dementia in older adults: a longitudinal analysis
Introduction: Mid/late-life cognitive activities are associated with a lower rate of subsequent cognitive decline and lower subsequent dementia risk over time.Methods: In this study, we investigated the association between adult education class participation and subsequent cognitive decline and dementia risk over time after adjusting for baseline cognitive function and genetic risk of dementia, correcting for several potential… Continue reading Effects of adult #education on #cognitive function and risk of #dementia in older adults: a longitudinal analysis
Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal #Parkinson’s disease
•α-syn32-46 immunization of HLA-DRB1∗15:01 mice triggers weight loss and constipation•α-syn32-46 immunizations induce inflammation and neuron loss in the gut•Depletion of CD4+, but not CD8+, T cells partially rescues enteric neural loss•Both α-syn32-46 and HLA-DRB1∗15:01 are critical for this model of prodromal PD SummaryEnteric symptoms are hallmarks of prodromal Parkinson’s disease (PD) that appear decades before the onset of motor… Continue reading Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal #Parkinson’s disease
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