Many acute treatment options exist for migraine. However, large-scale, head-to-head comparisons of treatment effectiveness from real-world patient experience reports are lacking.MethodsThis is a retrospective analysis of 10,842,795 migraine attack records extracted from an e-diary smartphone application between June 30, 2014, and July 2, 2020. We analyzed 25 acute medications among seven classes- acetaminophen, NSAIDs, triptans,… Continue reading Simultaneous Comparisons of 25 Acute #Migraine Medications Based on 10 Million Users’ Self-Reported Records From a Smartphone Application
Category: Neurology
Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red #wine #headaches
The consumption of red wine induces headaches in some subjects who can drink other alcoholic beverages without suffering. The cause for this effect has been attributed to a number of components, often the high level of phenolics in red wine, but a mechanism has been elusive. Some alcohol consumers exhibit flushing and experience headaches, and… Continue reading Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red #wine #headaches
Association between #sleep hours and changes in #cognitive function according to the morningness-eveningness type: A population-based study
The aim of this study was to investigate proper sleep hours to reduce the risk of cognitive decrease considering morningness-eveningness type.MethodsThe Korean Community Health Survey was used, which includes adults aged over 19 years old. These data were obtained from a cross-sectional study and assessed sleep hours using questionnaire of Pittsburgh Sleep Quality Index. Based on the wake-up time… Continue reading Association between #sleep hours and changes in #cognitive function according to the morningness-eveningness type: A population-based study
Polygenic predisposition, #sleep duration, and #depression: evidence from a prospective population-based cohort
Suboptimal sleep durations and depression frequently cooccur. Short-sleep and long-sleep are commonly thought of as symptoms of depression, but a growing literature suggests that they may be prodromal. While each represents a process of mutual influence, the directionality between them remains unclear. Using polygenic scores (PGS), we investigate the prospective direction involved in suboptimal sleep… Continue reading Polygenic predisposition, #sleep duration, and #depression: evidence from a prospective population-based cohort
The endocannabinoid N-arachidonoyl dopamine is critical for #hyperalgesia induced by chronic #sleep disruption
Chronic pain is highly prevalent and is linked to a broad range of comorbidities, including sleep disorders. Epidemiological and clinical evidence suggests that chronic sleep disruption (CSD) leads to heightened pain sensitivity, referred to as CSD-induced hyperalgesia. However, the underlying mechanisms are unclear. The thalamic reticular nucleus (TRN) has unique integrative functions in sensory processing,… Continue reading The endocannabinoid N-arachidonoyl dopamine is critical for #hyperalgesia induced by chronic #sleep disruption
Association Between #Triglycerides and Risk of #Dementia in Community-Dwelling #Older Adults: A Prospective Cohort Study
Background and Objectives: It has been suggested that higher triglyceride levels were associated with a lower risk of Alzheimer's disease. This study aimed to examine the association of triglycerides with dementia and cognition change in community-dwelling older adults.Methods: This prospective longitudinal study used data from the ASPREE randomized trial of adults aged ≥65 years without dementia or… Continue reading Association Between #Triglycerides and Risk of #Dementia in Community-Dwelling #Older Adults: A Prospective Cohort Study
#Proton pump inhibitors and #dementia: A nationwide population-based study
Proton pump inhibitors (PPIs) may increase dementia risk. However, it is currently unknown whether timing of exposure or age at dementia diagnosis influence the risk.METHODSWe assessed associations between cumulative PPI use and dementia at different ages in a nationwide Danish cohort of 1,983,785 individuals aged 60 to 75 years between 2000 and 2018.RESULTSDuring follow-up, there… Continue reading #Proton pump inhibitors and #dementia: A nationwide population-based study
#Sleeping Difficulties, #Sleep Duration, and Risk of #Hypertension in Women
Rates of poor sleep and hypertension are alarming worldwide. In this study, we investigate the association between sleeping difficulties and sleep duration with hypertension risk in women.METHODS:Sixty-six thousand one hundred twenty-two participants of the NHS2 (Nurses’ Health Study 2), who were free of hypertension at baseline (2001), were followed prospectively for 16 years and incident… Continue reading #Sleeping Difficulties, #Sleep Duration, and Risk of #Hypertension in Women
#Dementia;What you know about?
Dementia;What you know about?
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