Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its metabolic requirements. Here we show that OSKM reprogramming in mice causes a global depletion of vitamin B12 and molecular hallmarks of methionine starvation. Supplementation with vitamin B12 increases the efficiency… Continue reading Vitamin #B12 is a limiting factor for induced cellular plasticity and #tissue repair
Category: Diet
Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis
Clinical and preclinical studies established that supplementing diets with ω3 polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic steatohepatitis (NASH) but molecular underpinnings of this action were elusive. Herein, we used multi-omic network analysis that unveiled critical molecular pathways involved in ω3 PUFA effects in a preclinical mouse model of western diet induced… Continue reading Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis
Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red #wine #headaches
The consumption of red wine induces headaches in some subjects who can drink other alcoholic beverages without suffering. The cause for this effect has been attributed to a number of components, often the high level of phenolics in red wine, but a mechanism has been elusive. Some alcohol consumers exhibit flushing and experience headaches, and… Continue reading Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red #wine #headaches
Consumption of ultra-processed #foods and risk of multimorbidity of #cancer and #cardiometabolic diseases: a multinational cohort study
It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic diseases in an individual among first cancer at any site, cardiovascular disease, and… Continue reading Consumption of ultra-processed #foods and risk of multimorbidity of #cancer and #cardiometabolic diseases: a multinational cohort study
The Potential Role of Vitamin #E in Managing Non-Alcoholic Fatty #Liver Disease: Insights from Japan’s Aichi Medical University Study
Non-Alcoholic Fatty Liver Disease (NAFLD) has emerged as a significant public health concern, affecting millions of individuals worldwide. Characterized by the accumulation of fat in the liver without excessive alcohol consumption, NAFLD can progress to more severe conditions, such as non-alcoholic steatohepatitis (NASH) and cirrhosis. While lifestyle modifications remain a cornerstone in managing NAFLD, recent… Continue reading The Potential Role of Vitamin #E in Managing Non-Alcoholic Fatty #Liver Disease: Insights from Japan’s Aichi Medical University Study
Effect of Dietary #Sodium on Blood #PressureA Crossover Trial
Dietary sodium recommendations are debated partly due to variable blood pressure (BP) response to sodium intake. Furthermore, the BP effect of dietary sodium among individuals taking antihypertensive medications is understudied.Objectives To examine the distribution of within-individual BP response to dietary sodium, the difference in BP between individuals allocated to consume a high- or low-sodium diet first,… Continue reading Effect of Dietary #Sodium on Blood #PressureA Crossover Trial
Associations between Metabolomic Biomarkers of #Avocado Intake and #Glycemia in the Multi-Ethnic Study of Atherosclerosis
BackgroundAvocado consumption is linked to better glucose homeostasis, but small associations suggest potential population heterogeneity. Metabolomic data capture the effects of food intake after digestion and metabolism, thus accounting for individual differences in these processes.ObjectivesTo identify metabolomic biomarkers of avocado intake and to examine their associations with glycemia.MethodsBaseline data from 6224 multi-ethnic older adults (62% female) included self-reported avocado… Continue reading Associations between Metabolomic Biomarkers of #Avocado Intake and #Glycemia in the Multi-Ethnic Study of Atherosclerosis
Dietary #Sodium Intake and Risk of Incident Type 2 #Diabetes
ObjectiveTo fill the knowledge gap of the relation between long-term dietary sodium intake and type 2 diabetes (T2D), we evaluate the association between the frequency of adding salt to foods, a surrogate marker for evaluating the long-term sodium intake, and incident T2D risk.MethodsA total of 402,982 participants from UK Biobank (March 13, 2006 – October… Continue reading Dietary #Sodium Intake and Risk of Incident Type 2 #Diabetes
Untargeted metabolomic analysis investigating links between unprocessed red #meat intake and markers of #inflammation
BackgroundWhether red meat consumption is associated with higher inflammation or confounded by increased adiposity remains unclear. Plasma metabolites capture the effects of diet after food is processed, digested, and absorbed, and correlate with markers of inflammation, so they can help clarify diet-health relationships.ObjectiveTo identify whether any metabolites associated with red meat intake are also associated… Continue reading Untargeted metabolomic analysis investigating links between unprocessed red #meat intake and markers of #inflammation
