The sodium–glucose cotransporter 2 inhibitor dapagliflozin reduced the risk of cardiovascular mortality and worsening heart failure in the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure (DAPA-HF) trial. This report explores the effect of dapagliflozin on incident type 2 diabetes (T2D) in the cohort without diabetes enrolled in the trial RESEARCH DESIGN AND METHODS… Continue reading #Dapagliflozin and the Incidence of Type 2 #Diabetes in Patients With #Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis From DAPA-HF
Category: Cardiology
Prognostic value of #electrocardiographic abnormalities in adults from the Brazilian longitudinal study of adults’ health
Cardiovascular diseases (CVDs) are highly preventable non-communicable diseases. ECG is a potential tool for risk stratification with respect to CVD. Our aim was to evaluate ECG’s role in all-cause and cardiovascular mortality prediction. Methods Participants from the Brazilian Longitudinal Study of Adult Health, free of known CVD at baseline were included. A 12-lead ECG was… Continue reading Prognostic value of #electrocardiographic abnormalities in adults from the Brazilian longitudinal study of adults’ health
Association between Pre-Existing #Coronary Artery Disease and 5-Year Mortality in #Stroke Patients with High-Grade Carotid Artery Stenosis
The coincidence of coronary artery disease (CAD) and carotid artery stenosis (CAS) was observed. However, the association between pre-existing CAD and ischemic stroke (IS) outcome in patients with high-grade CAS remains unclear. We aimed to investigate the association between pre-existing CAD and outcomes of acute IS patients with high-grade CAS. Methods: From January 1, 2007,… Continue reading Association between Pre-Existing #Coronary Artery Disease and 5-Year Mortality in #Stroke Patients with High-Grade Carotid Artery Stenosis
#Cardiovascular health metrics from mid- to late-life and risk of #dementia: A population-based cohort study in Finland
Very few studies have explored the patterns of cardiovascular health (CVH) metrics in midlife and late life in relation to risk of dementia. We examined the associations of composite CVH metrics from midlife to late life with risk of incident dementia. This cohort study included 1,449 participants from the Finnish Cardiovascular Risk Factors, Aging, and… Continue reading #Cardiovascular health metrics from mid- to late-life and risk of #dementia: A population-based cohort study in Finland
#Neutrophil more than #platelet activation associates with #thrombotic complications in #COVID-19 patients
SARS-CoV-2 infection is associated with hypercoagulability which predisposes to venous thromboembolism (VTE). We analyzed platelet and neutrophil activation in COVID-19 patients and their association with VTE. Methods Hospitalized COVID-19 patients and age- and sex-matched healthy controls were studied. Platelet and leukocyte activation, neutrophil extracellular traps (NETs), and matrix metalloproteinase-9 (MMP-9), a neutrophil-released enzyme, were measured.… Continue reading #Neutrophil more than #platelet activation associates with #thrombotic complications in #COVID-19 patients
Dynamic changes in DICER levels in #adipose tissue control metabolic adaptations to #exercise
DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body… Continue reading Dynamic changes in DICER levels in #adipose tissue control metabolic adaptations to #exercise
Elevated #Coronary Artery Calcium scores are associated with #tooth loss
This study explores the association between Coronary Artery Calcium (CAC) scores and dental pathology such as missing teeth, the (peri-apical) health status and restoration grade of the teeth, and the grade of alveolar bone loss seen on a dental panoramic radiograph (Orthopantomograph–OPG).. ..212 patients were included. We found a statistically significant association between the number… Continue reading Elevated #Coronary Artery Calcium scores are associated with #tooth loss
Association Between #Depressive Symptoms and Incident #Cardiovascular Diseases
It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs).. ..Primary outcomes were incident fatal or nonfatal coronary heart disease (CHD), stroke, and CVD (composite of the 2). Hazard ratios (HRs) per 1-SD higher log CES-D or PHQ-2 adjusted for age, sex, smoking, and diabetes were reported. Results Among… Continue reading Association Between #Depressive Symptoms and Incident #Cardiovascular Diseases
#Lipoprotein (a) and the risk of elevated #depressive symptoms: The Multi-Ethnic Study of Atherosclerosis
Previous studies suggested a potential relationship between plasma lipoprotein (a) [Lp(a)] and elevated depressive symptoms. We aimed to investigate any such relationship in the Multi-Ethnic Study of Atherosclerosis participants who were free of cardiovascular events. Analysis included 4938 participants without elevated depressive symptoms and with Lp(a) levels measured at baseline. Participants were examined at four… Continue reading #Lipoprotein (a) and the risk of elevated #depressive symptoms: The Multi-Ethnic Study of Atherosclerosis
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