Nearly 3% of adults have attention-deficit and hyperactivity disorder (ADHD), although in the UK, most are undiagnosed. Adults with ADHD on average experience poorer educational and employment outcomes, worse physical and mental health and are more likely to die prematurely. No studies have yet used mortality data to examine the life expectancy deficit experienced by… Continue reading #Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Author: aledopress
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Association of #Diet and #Waist-to-Hip Ratio With Brain Connectivity and #Memory in #Aging
Importance Epidemiological studies suggest that lifestyle factors are associated with risk of dementia. However, few studies have examined the association of diet and waist to hip ratio (WHR) with hippocampus connectivity and cognitive health.Objective To ascertain how longitudinal changes in diet quality and WHR during midlife are associated with hippocampal connectivity and cognitive function in… Continue reading Association of #Diet and #Waist-to-Hip Ratio With Brain Connectivity and #Memory in #Aging
Suboptimal #dietary patterns are associated with accelerated biological #aging in young adulthood: A study with twins
Background & aimsSuboptimal diets increase morbidity and mortality risk. Epigenetic clocks are algorithms that can assess health and lifespan, even at a young age, before clinical manifestations of diseases. We investigated the association between dietary patterns and biological aging in young adult twins.MethodsThe data were drawn from the population-based FinnTwin12 study and consisted of twins… Continue reading Suboptimal #dietary patterns are associated with accelerated biological #aging in young adulthood: A study with twins
A dual-pathway architecture for #stress to disrupt agency and promote #habit
Chronic stress can change how we learn and, thus, how we make decisions1,2,3,4,5. Here we investigated the neuronal circuit mechanisms that enable this. Using a multifaceted systems neuroscience approach in male and female mice, we reveal a dual-pathway, amygdala–striatal neuronal circuit architecture by which a recent history of chronic stress disrupts the action–outcome learning underlying… Continue reading A dual-pathway architecture for #stress to disrupt agency and promote #habit
#Higher income is associated with greater life satisfaction, and more #stress
Is there a cost to our well-being from increased affluence? Drawing upon responses from 2.05 million U.S. adults from the Gallup Daily Poll from 2008 to 2017 we find that with household income above ~$63,000 respondents are more likely to experience stress. This contrasts with the trend below this threshold, where at higher income the… Continue reading #Higher income is associated with greater life satisfaction, and more #stress
#Aspirin prevents #metastasis by limiting platelet TXA2 suppression of T cell #immunity
Metastasis is the spread of cancer cells from primary tumours to distant organs and is the cause of 90% of cancer deaths globally1,2. Metastasizing cancer cells are uniquely vulnerable to immune attack, as they are initially deprived of the immunosuppressive microenvironment found within established tumours3. There is interest in therapeutically exploiting this immune vulnerability to… Continue reading #Aspirin prevents #metastasis by limiting platelet TXA2 suppression of T cell #immunity
Impact of different types of physical #exercise on sleep quality in older population with #insomnia: a systematic review and network meta-analysis of randomised controlled trials
Objective To measure the impact of each type of exercise on sleep quality and identify the exercise that enhances sleep quality the most.Study selection Eligible randomised controlled trials that compare physical exercise to routine activities, usual care, non-physical activity, or health education to measure the Pittsburgh Sleep Quality Index.Data source Studies retrieved from Medline, Embase,… Continue reading Impact of different types of physical #exercise on sleep quality in older population with #insomnia: a systematic review and network meta-analysis of randomised controlled trials
Glucagon-Like Peptide-1 Receptor Agonists and Risk for #Depression in Older Adults With Type 2 #Diabetes
Background:Although glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown potential antidepressant effects, population studies yield inconsistent results. Objective:To compare the risk for depression in older adults with type 2 diabetes (T2D) initiating treatment with GLP-1RAs versus sodium–glucose cotransporter-2 inhibitors (SGLT2is) or dipeptidyl peptidase-4 inhibitors (DPP4is).Design:Target trial emulation study.Setting:U.S. National Medicare administrative data from January 2014 to… Continue reading Glucagon-Like Peptide-1 Receptor Agonists and Risk for #Depression in Older Adults With Type 2 #Diabetes
#Dairy Consumption and the Colonic Mucosa-Associated Gut #Microbiota in Humans—A Preliminary Investigation
Background: Dairy consumption has been associated with various health outcomes that may be mediated by changes in gut microbiota. Methods: This cross-sectional study investigated the association between the colonic mucosa-associated gut microbiota and the self-reported intake of total dairy, milk, cheese, and yogurt. A total of 97 colonic mucosal biopsies collected from 34 polyp-free individuals… Continue reading #Dairy Consumption and the Colonic Mucosa-Associated Gut #Microbiota in Humans—A Preliminary Investigation
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