Introduction: This study explores the potential associations between COVID-19 vaccination and neuropsychiatric conditions. Methods: Data were collected from the CDC and FDA. The VAERS database was queried from January 1, 1990, to December 27, 2024, for adverse events (AEs) involving neuropsychiatric complications following COVID-19 vaccination. The timeframe included 420 months for all vaccines except COVID-19… Continue reading Association Between #COVID-19 #Vaccination and #Neuropsychiatric Conditions
Author: aledopress
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Exposure to per- and poly-fluoroalkyl substances in association to later occurrence of type 2 #diabetes and metabolic pathway #dysregulation in a multiethnic US population
Growing evidence suggests that exposure to per- and polyfluoroalkyl substances ( #PFAS ) are linked to an increased risk of type 2 diabetes (T2D); however, the effect of PFAS mixtures and underlying mechanisms are not well understood. We examined the associations between exposure to PFAS mixture with later T2D diagnosis and underlying metabolic dysregulations.MethodsWe conducted… Continue reading Exposure to per- and poly-fluoroalkyl substances in association to later occurrence of type 2 #diabetes and metabolic pathway #dysregulation in a multiethnic US population
Daily #steps and #health outcomes in #adults: a systematic review and dose-response meta-analysis
BackgroundDespite the rapid increase in evidence from the past decade on daily steps and health-related outcomes, existing systematic reviews primarily focused on few outcomes, such as all-cause mortality. This study synthesised the prospective dose-response relationship between daily steps and health outcomes including all-cause mortality, cardiovascular disease, cancer, type 2 diabetes, cognitive outcomes, mental health outcomes,… Continue reading Daily #steps and #health outcomes in #adults: a systematic review and dose-response meta-analysis
Classification of #Parkinson’s disease and isolated #REM sleep behaviour disorder: delineating progression markers from the sebum volatilome
Parkinson’s Disease (PD) has been associated with a distinct odour, emanating from the skin and strongest in sebum-rich areas. Here, volatile components from sebum were analysed directly with Thermal Desorption Gas Chromatography - Mass Spectrometry. We analysed samples from subjects with clinically established PD (n = 46), controls (n = 28) and participants with isolated REM sleep behaviour disorder… Continue reading Classification of #Parkinson’s disease and isolated #REM sleep behaviour disorder: delineating progression markers from the sebum volatilome
Association of #Weekend #Warrior and Other Physical #Activity Patterns With #Mortality Among Adults With #Diabetes: A Cohort Study
Background:“Weekend warrior” and regularly active physical activity patterns have been associated with reduced mortality risk in the general population. The association in patients with diabetes is unknown.Objective:To examine the associations of different physical activity patterns, particularly weekend warrior and regularly active behavior, with all-cause, cardiovascular, and cancer mortality among adults with diabetes.Design:Prospective cohort study.Setting:National Health… Continue reading Association of #Weekend #Warrior and Other Physical #Activity Patterns With #Mortality Among Adults With #Diabetes: A Cohort Study
Controlled colonization of the human #gut with a genetically engineered microbial therapeutic
Editor’s summaryThe gut #microbiota has long been an aspirational target for clinical delivery of therapeutics. Successful therapy by this route depends on ensuring engraftment of the therapeutic organisms and their clearance after treatment. Whitaker et al. have engineered a strain of Bacteroides vulgatus, which is commonly found in the gut of healthy humans, with two… Continue reading Controlled colonization of the human #gut with a genetically engineered microbial therapeutic
Effects of various #exercise interventions in #insomnia patients: a systematic review and network meta-analysis
Objectives To compare the effectiveness of different exercise interventions in improving sleep quality and alleviating insomnia severity among patients with insomnia.Design Our study design was a systematic review and network meta-analysis.Eligibility criteria Our study eligibility criteria was restricted to include randomised controlled trials (RCTs) involving adults with insomnia that evaluated exercise-based interventions.Data sources PubMed, Cochrane… Continue reading Effects of various #exercise interventions in #insomnia patients: a systematic review and network meta-analysis
Association of #Egg Intake With #Alzheimer’s #Dementia Risk in #Older Adults: The Rush #Memory and Aging Project
BackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder with increasing prevalence due to population aging. Eggs provide many nutrients important for brain health, including choline, omega-3 fatty acids, and lutein. Emerging evidence suggests that frequent egg consumption may improve cognitive performance on verbal tests, but whether consumption influences the risk of Alzheimer’s dementia and AD is… Continue reading Association of #Egg Intake With #Alzheimer’s #Dementia Risk in #Older Adults: The Rush #Memory and Aging Project
#AI -guided patient stratification improves outcomes and efficiency in the AMARANTH #Alzheimer’s Disease clinical trial
Alzheimer’s Disease (AD) drug discovery has been hampered by patient heterogeneity, and the lack of sensitive tools for precise stratification. Here, we demonstrate that our robust and interpretable AI-guided tool (predictive prognostic model, PPM) enhances precision in patient stratification, improving outcomes and decreasing sample size for a AD clinical trial. The AMARANTH trial of lanabecestat,… Continue reading #AI -guided patient stratification improves outcomes and efficiency in the AMARANTH #Alzheimer’s Disease clinical trial
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