The risk of stroke in individuals with very low low-density lipoprotein cholesterol (LDL-C) concentrations remains high. We sought to prioritize predictive risk factors for stroke in Chinese participants with LDL-C concentrations < 70 mg/dL using a survival conditional inference tree, a machine learning method. MethodsThe training dataset included 9327 individuals with LDL-C concentrations < 70 mg/dL who were free… Continue reading The risk of ischemic #stroke and hemorrhagic stroke in Chinese adults with low-density lipoprotein #cholesterol concentrations < 70 mg/dL
Author: aledopress
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All #coffee types decrease the risk of adverse clinical outcomes in chronic #liver disease: a UK Biobank study
Chronic liver disease (CLD) is a growing cause of morbidity and mortality worldwide, particularly in low to middle-income countries with high disease burden and limited treatment availability. Coffee consumption has been linked with lower rates of CLD, but little is known about the effects of different coffee types, which vary in chemical composition. This study… Continue reading All #coffee types decrease the risk of adverse clinical outcomes in chronic #liver disease: a UK Biobank study
Comparison of Novel Biomarkers with Conventional #HBV Markers among Untreated Adults with Chronic #Hepatitis B in North America
The clinical utility of two novel biomarkers, hepatitis B virus (HBV) RNA and hepatitis B core-related antigen (HBcrAg), as compared to conventional markers of HBV replication and disease activity is unclear. Untreated participants in the North American Hepatitis B Research Network Adult Cohort Study were categorized by chronic hepatitis B (CHB) phases based on HBsAg… Continue reading Comparison of Novel Biomarkers with Conventional #HBV Markers among Untreated Adults with Chronic #Hepatitis B in North America
#Homocysteine predicts vascular target organ damage in #hypertension and may serve as guidance for first-line antihypertensive therapy
Homocysteine is an independent risk factor for cardiovascular and cerebrovascular disease and has been proposed to contribute to vascular dysfunction. We sought to determine in a real-world clinical setting whether homocysteine levels were associated with hypertension mediated organ damage (HMOD) and could guide treatment choices in hypertension. We performed a cross-sectional analysis of prospectively collected… Continue reading #Homocysteine predicts vascular target organ damage in #hypertension and may serve as guidance for first-line antihypertensive therapy
Multiple #SARS-CoV-2 variants escape neutralization by #vaccine-induced humoral immunity
Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of these variants, we evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines… Continue reading Multiple #SARS-CoV-2 variants escape neutralization by #vaccine-induced humoral immunity
A phase 2 trial of inhaled #nitrous oxide for treatment-resistant major #depression
Laughing gas improves depressionAbout one-third of individuals suffering from depression are at risk for treatment resistance. Whereas inhaled 50% nitrous oxide has early antidepressant effects on individuals with treatment-resistant major depression (TRMD), adverse effects can occur at this concentration. In this phase 2 clinical trial, Nagele et al. studied the effects of a single 1-hour… Continue reading A phase 2 trial of inhaled #nitrous oxide for treatment-resistant major #depression
#Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to #stress via regulation of FKBP5
Responding to different dynamic levels of stress is critical for mammalian survival. Disruption of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to underlie hypothalamic-pituitary-adrenal (HPA) axis dysregulation observed in stress-related psychiatric disorders. In this study, we show that FK506-binding protein 51 (FKBP5) plays a critical role in fine-tuning MR:GR balance in the… Continue reading #Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to #stress via regulation of FKBP5
#Thyroid Hormone Therapy and Incident #Stroke
Stroke is a leading cause of death and disability and there is a need to identify modifiable risk factors. ObjectiveDetermine the relationship between thyroid hormone treatment intensity and incidence of atrial fibrillation and stroke. DesignRetrospective cohort study using data from the Veterans Health Administration between 2004 and 2017, with a median follow-up of 59 months.… Continue reading #Thyroid Hormone Therapy and Incident #Stroke
Effect of #bariatric surgery on ischemic #stroke risk
Bariatric surgery has demonstrated improvements in cardiovascular health. The effect on ischemic stroke risk remains unclear. The goal of this study was to compare the risk of stroke among bariatric surgery patients versus controls. MethodsUsing Mariner, a national all-payer claims database, we identified patients with BMI > 40, or BMI > 35 with qualifying comorbidities… Continue reading Effect of #bariatric surgery on ischemic #stroke risk
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