The effectiveness of Zhi-Shi plaster acupoint therapy combined with lactulose in the treatment of geriatrics functional constipation: a randomized controlled trial

Objective: This study aimed to evaluate the effectiveness and adverse effects of Zhi-Shi plaster acupoint therapy combined with Lactulose in the Treatment of geriatrics Functional Constipation.Methods: A total of 62 geriatrics Functional Constipation patients were randomly assigned to the intervention group (n = 31) and control group (n = 31). The intervention group received oral lactulose (20 mL daily for… Continue reading The effectiveness of Zhi-Shi plaster acupoint therapy combined with lactulose in the treatment of geriatrics functional constipation: a randomized controlled trial

Small-colony variants of #Staphylococcus aureus: hidden threat in chronic and recurrent #infections

Staphylococcus aureus small-colony variants (SCVs) are unique phenotypic forms that significantly contribute to the development of chronic, recurrent, and treatment-refractory infections. These variants arise from metabolic defects, most commonly in the menadione, hemin, or thymidine biosynthetic pathways, leading to slow growth, atypical colony morphology, and altered virulence expression. The ability of these bacteria to persist… Continue reading Small-colony variants of #Staphylococcus aureus: hidden threat in chronic and recurrent #infections

Real-World outcomes of oral #anticoagulation in patients with atrial #fibrillation at high risk of both #bleeding anand Asia-Pacificd stroke: observational evidence from three international registries from middle East, Europe

To evaluate the clinical course of patients with AF at high risk for both bleeding and stroke, according to OAC use. Data were analysed from three registries across the Middle East, Europe, and Asia-Pacific regions. The study only included 'high risk' patients with AF and CHA₂DS₂-VASc scores ≥ 2 and HAS-BLED scores ≥ 3, who… Continue reading Real-World outcomes of oral #anticoagulation in patients with atrial #fibrillation at high risk of both #bleeding anand Asia-Pacificd stroke: observational evidence from three international registries from middle East, Europe

#Wearable -derived heart rate variability and sleep monitoring as predictors of #mood episodes in bipolar disorder: a case report

Background: Bipolar disorder is a chronic psychiatric condition characterized by alternating episodes of mania and depression, and the prediction and management of mood episodes remain significant clinical challenges. Traditional assessments of mood states have largely relied on subjective methods, such as clinical interviews and self-report questionnaires, which present limitations in terms of early detection and… Continue reading #Wearable -derived heart rate variability and sleep monitoring as predictors of #mood episodes in bipolar disorder: a case report

An Analysis of Initial Loop #Diuretic Dosing Strategies and Its Association with Time to #Decongestion

Background: There is currently a lack of evidence on the optimal loop diuretic dosing strategy in cases of acute decompensated heart failure (ADHF). Current consensus recommendations suggest starting with a dose of at least 2 times the patient’s home loop diuretic dose. Objective: This study assessed whether higher initial loop diuretic doses are associated with… Continue reading An Analysis of Initial Loop #Diuretic Dosing Strategies and Its Association with Time to #Decongestion

Effect of Sodium-Glucose Co-transporter 2 ( #SGLT2 ) Inhibitors in the Management of #Hyponatremia Associated With Syndrome of Inappropriate Antidiuresis

AbstractBackground: Hyponatremia due to syndrome of inappropriate antidiuresis (SIAD) is a common and challenging electrolyte disorder, particularly in hospitalized and elderly patients. Conventional treatments, such as fluid restriction and vasopressin receptor antagonists, have limitations related to efficacy, tolerance, availability, and cost. Sodium-glucose co-transporter 2 inhibitors (SGLT2i), primarily used for type 2 diabetes, have shown potential… Continue reading Effect of Sodium-Glucose Co-transporter 2 ( #SGLT2 ) Inhibitors in the Management of #Hyponatremia Associated With Syndrome of Inappropriate Antidiuresis

The Impact of #Probiotics on #Acne Vulgaris: A Meta-Analysis of Randomized Controlled Trials

Acne vulgaris is a multifactorial inflammatory skin disorder influenced by hormonal activity, microbial imbalance, and immune dysregulation. While conventional treatments such as antibiotics and retinoids remain effective, their long-term use is often limited by side effects, resistance, and poor adherence. This meta-analysis evaluated the efficacy of probiotics as an adjunct or alternative therapy for acne… Continue reading The Impact of #Probiotics on #Acne Vulgaris: A Meta-Analysis of Randomized Controlled Trials

Effects of #Electroacupuncture at #ST36 on Visceral Pain and Inflammatory Markers in #IBS Rats

Irritable bowel syndrome (IBS) is characterized by recurrent visceral pain associated with low-grade gut inflammation. Electroacupuncture (EA) at acupoint ST36 (Zusanli) is reputed to alleviate gastrointestinal disorders, but its effects on IBS-related visceral hypersensitivity and inflammation remain to be fully elucidated. This study evaluated whether EA at ST36 attenuates visceral pain and modulates key inflammatory… Continue reading Effects of #Electroacupuncture at #ST36 on Visceral Pain and Inflammatory Markers in #IBS Rats

Clinical outcomes of #orthopaedic surgery patients with inferior vena #cava filter prophylaxis

AbstractPurpose: Orthopaedic surgery patients are at an elevated risk of venous thromboembolic events thus necessitating effective prophylaxis strategies.Methods: This IRB-approved, single-center retrospective study evaluated patients who underwent orthopaedic surgery and were protected with Inferior Vena Cava (IVC) filters from January 2007 to December 2021. Study outcomes include incidence of venous thromboembolism (VTE) in the form… Continue reading Clinical outcomes of #orthopaedic surgery patients with inferior vena #cava filter prophylaxis