Type 2 diabetes mellitus (T2DM) has shown to be associated with carotid plaque vulnerability. However, the impact of T2DM on intracranial artery atherosclerosis is not well‐understood. Purpose To evaluate the association of diabetes and glycemic control with intracranial atherosclerotic plaque characteristics identified by three‐dimensional contrast enhanced MR vessel wall imaging in patients after acute ischemic stroke. Study Type Prospective. Population Two hundred and eighty‐eight symptomatic … Continue reading Association of Type 2 #Diabetes Mellitus and Glycemic Control With Intracranial Plaque Characteristics in Patients With Acute Ischemic #Stroke
The development of high-throughput screening methodologies may decrease the need for laboratory animals for toxicity testing. Here, we investigate the potential of assessing immunotoxicity with high-throughput screening data from the U.S. Environmental Protection Agency ToxCast program. As case studies, we analyzed the most common chemicals added to food as well as per- and polyfluoroalkyl substances (PFAS) shown to migrate to food from packaging materials or … Continue reading Investigating Molecular Mechanisms of Immunotoxicity and the Utility of #ToxCast for Immunotoxicity Screening of Chemicals Added to #Food
Lamotrigine is used alone or with other medicines to treat seizures in patients 2 years and older. It may also be used as maintenance treatment in patients with the mental health condition bipolar disorder to help delay the occurrence of mood episodes such as depression, mania, or hypomania. RECOMMENDATIONS: Patients should not stop taking your medicine without first talking to your prescriber because stopping lamotrigine … Continue reading Lamictal (#lamotrigine): Drug Safety Communication – Studies Show Increased Risk of #Heart Rhythm Problems in Patients with Heart Disease
We assessed the burden of nonalcoholic fatty liver disease (NAFLD)‐related acute on chronic liver failure (ACLF) among transplant candidates in the United States, along with waitlist outcomes for this population. Approach and Results We analyzed the United Network for Organ Sharing registry from 2005 to 2017. Patients with ACLF were identified using the European Association for the Study of the Liver/Chronic Liver Failure criteria and … Continue reading Acute on Chronic Liver Failure From #Nonalcoholic Fatty #Liver Disease: A Growing and Aging Cohort With Rising Mortality
Evidence is mounting that cigarette smoking contributes to second primary contralateral breast cancer (CBC) risk. Whether radiation therapy (RT) interacts with smoking to modify this risk is unknown. In this multicenter, individually-matched case-control study, we examined the association between RT, smoking, and CBC risk. The study included 1,521 CBC cases and 2,212 controls with unilateral breast cancer, all diagnosed with first invasive breast cancer between … Continue reading #Smoking, #Radiation Therapy, and Contralateral #Breast Cancer Risk in Young Women
Because of the extensive use of this drug, further evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; ≤6 g/d) is required. We characterize ALI with therapeutic doses of APAP and determine the host factors associated with disease severity and the predictors of outcome. Approach and Results All patients admitted with severe APAP‐related ALI in our center were included from 2002 to … Continue reading Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study
Observational studies have linked cannabis use to an array of negative outcomes, including psychiatric symptoms, cognitive impairment, and educational and occupational underachievement. These associations are particularly strong when cannabis use occurs in adolescence. Nevertheless, causality remains unclear. The purpose of the present study was thus to examine associations between prospectively assessed adolescent cannabis use and young-adult outcomes (psychiatric, cognitive, and socioeconomic) in three longitudinal studies … Continue reading Associations between adolescent #cannabis use and young-adult functioning in three longitudinal twin studies
The COVID-19 pandemic has dramatically affected mental health, creating an urgent need for convenient and safe interventions to improve well-being. Online mindfulness interventions show promise for improving depression, anxiety, and general well-being. Objective To assess: 1) the impact of online mindfulness on psychological distress, 2) altruistic efforts, and 3) the quantity, quality, and availability of online mindfulness resources during the COVID-19 pandemic. Methods 233 participants … Continue reading Online #Mindfulness May Target Psychological #Distress and Mental Health during #COVID-19
Worldwide, the prevalence of dementia is increasing and diet as a modifiable factor could play a role. Meat consumption has been cross-sectionally associated with dementia risk, but specific amounts and types related to risk of incident dementia remain poorly understood. Objective We aimed to investigate associations between meat consumption and risk of incident dementia in the UK Biobank cohort. Methods Meat consumption was estimated using … Continue reading #Meat consumption and risk of incident #dementia: cohort study of 493,888 UK Biobank participants
Direct oral anticoagulants (DOACs) are increasingly used in place of warfarin, but evidence about their effectiveness and safety in patients with valvular atrial fibrillation (AF) remains limited. Objective: To assess the effectiveness and safety of DOACs compared with warfarin in patients with valvular AF. Design: New-user retrospective propensity score–matched cohort study. Setting: U.S.-based commercial health care database from 1 January 2010 to 30 June 2019. … Continue reading Effectiveness and Safety of Direct Oral #Anticoagulants Versus Warfarin in Patients With Valvular Atrial #Fibrillation
There is evidence that caffeine increases the maximal fat oxidation rate (MFO) and aerobic capacity, which are known to be lower in the morning than in the afternoon. This paper examines the effect of caffeine intake on the diurnal variation of MFO during a graded exercise test in active men. Methods Using a triple-blind, placebo-controlled, crossover experimental design, 15 active caffeine-naïve men (age: 32 ± 7 years) completed … Continue reading #Caffeine increases maximal #fat oxidation during a graded exercise test: is there a diurnal variation?
Research documents the pernicious effects of daily stressors on well-being, but often ignored in these studies are people reporting no stressors. The current study compared adults who reported no daily stressors with adults who reported at least one stressor across 8 consecutive days on measures of well-being. Of the 2,804 respondents (age range = 25–75 years, M = 53.46) from the Midlife in the United … Continue reading The mixed benefits of a #stressor-free life.