Circulating high-sensitivity cardiac troponin T (hsTnT) predominantly reflects myocardial injury, and higher levels are associated with a higher risk of worsening heart failure (HF) and death in patients with HF with reduced ejection fraction (HFrEF). Less is known about the prognostic significance of changes in hsTnT over time, the effects of dapagliflozin on clinical outcomes… Continue reading Serial Assessment of High-Sensitivity Cardiac #Troponin and the Effect of #Dapagliflozin in Patients with Heart #Failure with Reduced Ejection Fraction: An Analysis of the DAPA-HF Trial
Author: aledopress
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2021 #Dietary Guidance to Improve #Cardiovascular Health: A Scientific Statement From the American Heart Association
Poor diet quality is strongly associated with elevated risk of cardiovascular disease morbidity and mortality. This scientific statement emphasizes the importance of dietary patterns beyond individual foods or nutrients, underscores the critical role of nutrition early in life, presents elements of heart-healthy dietary patterns, and highlights structural challenges that impede adherence to heart-healthy dietary patterns.… Continue reading 2021 #Dietary Guidance to Improve #Cardiovascular Health: A Scientific Statement From the American Heart Association
A novel adverse effect of the BNT162b2 mRNA vaccine: First episode of acute #mania with #psychotic features
Dear Editor;A vaccine against SARS-CoV2, which is causing the global COVID-19 pandemic, was developed for the first-time using mRNA technology. Although the short- and long-term side-effects of the vaccine were unknown, emergency use authorization (EUA) was granted by the Food and Drug Administration (FDA) in December 2020(Parkash et al., 2021). Adverse effects such as tiredness,… Continue reading A novel adverse effect of the BNT162b2 mRNA vaccine: First episode of acute #mania with #psychotic features
Country roads, take me home… to my friends: How #intelligence, population density, and friendship affect modern #happiness
We propose the savanna theory of happiness, which suggests that it is not only the current consequences of a given situation but also its ancestral consequences that affect individuals’ life satisfaction and explains why such influences of ancestral consequences might interact with intelligence. We choose two varied factors that characterize basic differences between ancestral and… Continue reading Country roads, take me home… to my friends: How #intelligence, population density, and friendship affect modern #happiness
Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function
To investigate whether osteoarthritis (OA)–specific assessment values (i.e. Western Ontario and McMaster University Osteoarthritis Index [WOMAC]) and generic pain and function (visual analog scale [VAS], Hanover Functionality Status Questionnaire [FFbH]) measured before and 12 months after arthroplasty are associated with the risk of long-term mortality in a cohort of patients with advanced OA of the… Continue reading Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function
Disruption of autophagy by increased #5-HT alters gut microbiota and enhances susceptibility to experimental colitis and #Crohn’s disease
Autophagy, an essential intracellular recycling process, is linked to the pathogenesis of various diseases including Crohn’s disease (CD). Factors that lead to the development of impaired autophagy during intestinal inflammation remain largely unexplored. Here, we report the impact of the interaction between serotonin [5-hydroxytryptamine;(5-HT)] and autophagy in colitis in mouse and human studies. In mice,… Continue reading Disruption of autophagy by increased #5-HT alters gut microbiota and enhances susceptibility to experimental colitis and #Crohn’s disease
Genome-wide analysis of 53,400 people with #irritable bowel syndrome highlights shared genetic pathways with #mood and #anxiety disorders
Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe… Continue reading Genome-wide analysis of 53,400 people with #irritable bowel syndrome highlights shared genetic pathways with #mood and #anxiety disorders
Discovery of Autoantibodies Targeting #Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology
Failure of the glomerular filtration barrier, primarily by loss of slit diaphragm architecture, underlies nephrotic syndrome in minimal change disease. The etiology remains unknown. The efficacy of B cell-targeted therapies in some patients, together with the known proteinuric effect of antinephrin antibodies in rodent models, prompted us to hypothesize that nephrin autoantibodies may be present… Continue reading Discovery of Autoantibodies Targeting #Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology
EDP-305 in patients with #NASH: A phase II double-blind placebo-controlled dose-ranging study
•EDP-305 is an oral farnesoid X receptor (FXR) agonist being developed to treat nonalcoholic steatohepatitis (NASH).•In a randomized, placebo-controlled study, 12-week study, EDP-305 reduced ALT levels and MRI-PDFF•These results support further development of EDP-305 in patients with NASH with longer term studies. ABSTRACTBackground & AimsEDP-305 is an oral farnesoid X receptor (FXR) agonist under development… Continue reading EDP-305 in patients with #NASH: A phase II double-blind placebo-controlled dose-ranging study
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