Abstract: Background:The effect of sleep medications on cognition in older adults is controversial, possibly dependent upon sleep quality, and may differ by race. Objective:To determine the longitudinal association between sleep medication use and incident dementia over 15 years, and to explore whether the association is independent of nighttime sleep disturbances and if it differs by race.… Continue reading Race Differences in the Association Between Sleep Medication Use and Risk of Dementia
Author: aledopress
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Ultra-processed food consumption, cancer risk and cancer mortality: a large-scale prospective analysis within the UK Biobank
Global dietary patterns are increasingly dominated by relatively cheap, highly palatable, and ready-to-eat ultra-processed foods (UPFs). However, prospective evidence is limited on cancer development and mortality in relation to UPF consumption. This study examines associations between UPF consumption and risk of cancer and associated mortality for 34 site-specific cancers in a large cohort of British… Continue reading Ultra-processed food consumption, cancer risk and cancer mortality: a large-scale prospective analysis within the UK Biobank
Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey
IntroductionRecent evidence suggests that oxidative stress and endothelial dysfunction play critical roles in the pathophysiology of COVID-19 and Long-COVID. We hypothesized that a supplementation combining L-Arginine (to improve endothelial function) and Vitamin C (to reduce oxidation) could have favorable effects on Long-COVID symptoms.MethodsWe designed a survey (LINCOLN: L-Arginine and Vitamin C improves Long-COVID), assessing several symptoms that have been associated with Long-COVID to be administered… Continue reading Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey
Effectiveness of a Fermented Functional Food on Telomere Dynamics and miRNAs in Middle-Aged/Elderly Healthy Individuals: A 2-Year Randomized, Double-Blind, Controlled Clinical Trial
Background: A specific fermented papaya preparation (ORI-FPP®), has been well established with non clinical and clinical validation in modulating redox and immune systems as well as mitochondrial efficiency. In addition, recent data from the Italian NIH (National Institute of Health) have shown that this compound was able to increase telomeres length and telomerase activity in… Continue reading Effectiveness of a Fermented Functional Food on Telomere Dynamics and miRNAs in Middle-Aged/Elderly Healthy Individuals: A 2-Year Randomized, Double-Blind, Controlled Clinical Trial
Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population
The coronavirus disease 2019 (COVID-19) has been a challenge for the whole world since the beginning of 2020, and COVID-19 vaccines were considered crucial for disease eradication. Instead of producing classic vaccines, some companies pointed to develop products that mainly function by inducing, into the host, the production of the antigenic protein of SARS-CoV-2 called… Continue reading Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population
Physical interventions to interrupt or reduce the spread of respiratory viruses
...We included 11 new RCTs and cluster‐RCTs (610,872 participants) in this update, bringing the total number of RCTs to 78. Six of the new trials were conducted during the COVID‐19 pandemic; two from Mexico, and one each from Denmark, Bangladesh, England, and Norway. We identified four ongoing studies, of which one is completed, but unreported, evaluating masks… Continue reading Physical interventions to interrupt or reduce the spread of respiratory viruses
Predicting physician departure with machine learning on EHR use patterns: A longitudinal cohort from a large multi-specialty ambulatory practice
Physician turnover places a heavy burden on the healthcare industry, patients, physicians, and their families. Having a mechanism in place to identify physicians at risk for departure could help target appropriate interventions that prevent departure. We have collected physician characteristics, electronic health record (EHR) use patterns, and clinical productivity data from a large ambulatory based… Continue reading Predicting physician departure with machine learning on EHR use patterns: A longitudinal cohort from a large multi-specialty ambulatory practice
The reversible impairment of behavioral variant frontotemporal brain sagging syndrome: Challenges and opportunities
Due to loss of brain buoyancy, spontaneous spinal cerebrospinal fluid (CSF) leaks cause orthostatic headaches but also can cause symptoms indistinguishable from behavioral variant frontotemporal dementia (bvFTD) due to severe brain sagging (including the frontal and temporal lobes), as visualized on brain magnetic resonance imaging. However, the detection of these CSF leaks may require specialized… Continue reading The reversible impairment of behavioral variant frontotemporal brain sagging syndrome: Challenges and opportunities
Gut microbiome-wide association study of depressive symptoms
Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms underlying depression and the gut microbiome is a novel area of interest. Here we investigate the relation of fecal microbiome diversity and composition with depressive symptoms in 1,054 participants from the… Continue reading Gut microbiome-wide association study of depressive symptoms
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