Sedentary behaviour is very prevalent in modern societies, with young adults spending approximately 6 h/day sitting. Sitting induces declines in endothelial function, increasing the risk of cardiovascular diseases. Nutrition during sitting may be used as a strategy to minimise such effects. This acute randomised, counterbalanced, double-blinded, cross-over, placebo-controlled human study investigated whether intake of dietary… Continue reading Dietary #flavanols preserve upper- and lower-limb endothelial function during #sitting in high- and low-fit young healthy males
Tag: Vascular
#Cerebrovascular Effects of #Sildenafil in Small Vessel Disease: The OxHARP Trial
BACKGROUND:Vascular cognitive impairment due to cerebral small vessel disease is associated with cerebral pulsatility, white matter hypoperfusion, and reduced cerebrovascular reactivity (CVR), and is potentially improved by endothelium-targeted drugs such as cilostazol. Whether sildenafil, a phosphodiesterase-5 inhibitor, improves cerebrovascular dysfunction is unknown.METHODS:OxHARP trial (Oxford Haemodynamic Adaptation to Reduce Pulsatility) was a double-blind, randomized, placebo-controlled, 3-way… Continue reading #Cerebrovascular Effects of #Sildenafil in Small Vessel Disease: The OxHARP Trial
Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease
Background:Chronic kidney disease (CKD) accelerates vascular calcification via phenotypic switching of vascular smooth muscle cells (VSMCs). We investigated the roles of circulating small extracellular vesicles (sEVs) between the kidneys and VSMCs and uncovered relevant sEV-propagated microRNAs (miRNAs) and their biological signaling pathways.Methods and Results:We established CKD models in rats and mice by adenine-induced tubulointerstitial fibrosis.… Continue reading Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease
A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation–transcription coupling
Elevation of intracellular Ca2+ concentration ([Ca2+]i) activates Ca2+/calmodulin-dependent kinases (CaMK) and promotes gene transcription. This signaling pathway is referred to as excitation–transcription (E-T) coupling. Although vascular myocytes can exhibit E-T coupling, the molecular mechanisms and physiological/pathological roles are unknown. Multiscale analysis spanning from single molecules to whole organisms has revealed essential steps in mouse vascular… Continue reading A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation–transcription coupling
First time detection of the vaccine spike protein in a person who died after vaccination against Covid-19.
The suspicion that the spike protein formed in the body as a result of the "vaccination" against Covid-19 could be responsible for the pathologically observed inflammations and lesions of vessels has now been confirmed immunohistologically for the first time. The pathologists Prof. Dr. Arne Burkhardt and Prof. Dr. Walter Lang and their team have succeeded… Continue reading First time detection of the vaccine spike protein in a person who died after vaccination against Covid-19.
Ankle‐Brachial Index and Subsequent Risk of Severe #Ischemic #Leg Outcomes: The ARIC Study
Ankle‐brachial index (ABI) is used to identify lower‐extremity peripheral artery disease (PAD). However, its association with severe ischemic leg outcomes (eg, amputation) has not been investigated in the general population. Methods and ResultsAmong 13 735 ARIC (Atherosclerosis Risk in Communities) study participants without clinical manifestations of PAD (mean age, 54 [SD, 5.8] years; 44.4% men;… Continue reading Ankle‐Brachial Index and Subsequent Risk of Severe #Ischemic #Leg Outcomes: The ARIC Study
Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans
Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular diseases. We investigated whether increased circulating levels of the gut microbiome-generated metabolite trimethylamine-N-oxide induces endothelial dysfunction with aging. In healthy humans, plasma trimethylamine-N-oxide was higher in middle-aged/older (64±7 years) versus young (22±2 years) adults (6.5±0.7 versus 1.6±0.2 µmol/L) and inversely related to brachial artery flow-mediated… Continue reading Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans
IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed #vascular barrier disruption
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with rising incidence. Diseased tissues are heavily vascularized ..Specifically, we show that inhibition of the IFN-γ response in vessels by endothelial-specific knockout of IFN-γ receptor 2 ameliorates experimentally induced colitis in mice. IFN-γ acts pathogenic by causing a breakdown of the vascular barrier through disruption of… Continue reading IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed #vascular barrier disruption
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