Objective To address the comparative effectiveness of common interventional procedures for chronic non-cancer (axial or radicular) spine pain.Design Systematic review and network meta-analysis (NMA) of randomised controlled trials (RCTs).Data sources Medline, Embase, CINAHL, CENTRAL, and Web of Science from inception to 24 January 2023.Study selection RCTs that enrolled patients with chronic non-cancer spine pain, randomised… Continue reading Common interventional procedures for chronic non-cancer #spine #pain: a systematic review and network meta-analysis of randomised trials
Tag: Pain
Better #diet quality is associated with reduced body #pain in adults regardless of adiposity: Findings from the Whyalla Intergenerational Study of Health
Highlights•Better diet quality had a direct (beneficial) effect on pain.•Higher consumption of core foods was related to less pain in women, but not men.•Adiposity did not mediate the relationship between diet quality and pain.•Strategies for pain management should consider diet quality. AbstractDietary intake has been associated with pain and physical function, but it is unclear… Continue reading Better #diet quality is associated with reduced body #pain in adults regardless of adiposity: Findings from the Whyalla Intergenerational Study of Health
#Virtual reality for #pain management in hospitalized patients with #cancer: A randomized controlled trial
Hospitalized patients with cancer often experience acute and/or chronic pain. Although virtual reality (VR) has been extensively studied across a wide range of clinical settings, no studies have yet evaluated potential impact on pain management in this patient population.MethodsProspective randomized controlled trial at an urban academic hospital comparing VR against an active control to mitigate… Continue reading #Virtual reality for #pain management in hospitalized patients with #cancer: A randomized controlled trial
Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
Chronic musculoskeletal pain (CMP), a prevalent and heterogeneous condition characterized by persistent pain in various body parts, is a leading cause of disability worldwide and greatly affects a patient’s brain. Apart from experiencing pain, older adults with CMP also have accelerated cognitive decline and higher dementia risk with limited understanding of biological mechanism underlying the… Continue reading Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
The endocannabinoid N-arachidonoyl dopamine is critical for #hyperalgesia induced by chronic #sleep disruption
Chronic pain is highly prevalent and is linked to a broad range of comorbidities, including sleep disorders. Epidemiological and clinical evidence suggests that chronic sleep disruption (CSD) leads to heightened pain sensitivity, referred to as CSD-induced hyperalgesia. However, the underlying mechanisms are unclear. The thalamic reticular nucleus (TRN) has unique integrative functions in sensory processing,… Continue reading The endocannabinoid N-arachidonoyl dopamine is critical for #hyperalgesia induced by chronic #sleep disruption
Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
BackgroundStatin therapy is effective for the prevention of atherosclerotic cardiovascular disease and is widely prescribed, but there are persisting concerns that statin therapy might frequently cause muscle pain or weakness. We aimed to address these through an individual participant data meta-analysis of all recorded adverse muscle events in large, long-term, randomised, double-blind trials of statin… Continue reading Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Neural Signatures of Pain Modulation in Short-Term and Long-Term Mindfulness Training: A Randomized Active-Control Trial
Mindfulness-based interventions are widely used to target pain, yet their neural mechanisms of action are insufficiently understood. The authors studied neural and subjective pain response in a randomized active-control trial of mindfulness-based stress reduction (MBSR) alongside long-term meditation practitioners.Methods:Healthy participants (N=115) underwent functional neuroimaging during a thermal acute pain task before and after random assignment… Continue reading Neural Signatures of Pain Modulation in Short-Term and Long-Term Mindfulness Training: A Randomized Active-Control Trial
Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling
For millenniums, mindfulness was thought to diminish pain by reducing the influence of self-appraisals of noxious sensations. Today, mindfulness meditation is a highly popular and effective pain therapy that is thought to engage multiple, non-placebo related mechanisms to attenuate pain. Recent evidence suggests that mindfulness meditation-induced pain relief is associated with the engagement of unique… Continue reading Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling
Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants
Immune function and sensitivity to pain are closely related, but the association between early life inflammation and sensory nervous system development is poorly understood—especially in humans. Here, in term-born infants, we measure brain activity and reflex withdrawal activity (using EEG and EMG) and behavioural and physiological activity (using the PIPP-R score) to assess the impact… Continue reading Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants
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