SARS-CoV2 host cell infection is mediated by the binding to angiotensin-converting enzyme 2 (ACE2). Systemic dysregulation observed in SARS-CoV was previously postulated to be due to ACE2/Ang1-7/Mas axis downregulation, increased ACE2 activity was shown to mediate disease protection. Since angiotensin II receptor blockers (ARBs), ACE inhibitors, and mineralocorticoid receptor antagonists (MRAs) increase ACE2 receptor expression,… Continue reading Clinical Implications of SARS-Cov2 Interaction with Renin #Angiotensin System
Tag: Hypertension
Large #thigh circumference is associated with lower blood #pressure in overweight and obese individuals: a community-based study
..A small thigh circumference is associated with an increased risk of diabetes, cardiovascular diseases, and total mortality. The purpose of this study was to evaluate the association between thigh circumference and hypertension in the middle-aged and elderly population. ..Thigh circumference was negatively correlated with systolic blood pressure, diastolic blood pressure, fasting glucose, and total cholesterol.… Continue reading Large #thigh circumference is associated with lower blood #pressure in overweight and obese individuals: a community-based study
Joint Effects of #Body Mass Index and Waist Circumference on the Incidence of #Hypertension in a Community-Based Chinese Population
.. During 2.3 years of follow-up, 19.1% (n = 97) of the men and 13.6% (n = 158) of the women developed incident hypertension. The adjusted odds ratios (ORs) (95% confidence intervals [CIs]) for obesity (BMI ≥30) were 3.49 (1.59–7.66) and 2.60 (1.48–4.55) for men and women, respectively. A 1-point increase in BMI was associated… Continue reading Joint Effects of #Body Mass Index and Waist Circumference on the Incidence of #Hypertension in a Community-Based Chinese Population
Open Access Oral #glucocorticoids and incidence of #hypertension in people with chronic inflammatory diseases: a population-based cohort study
..Among 71 642 patients in the cohort, 24 896 (34.8%) developed hypertension during a median follow-up of 6.6 years. The incidence rate of hypertension was 46.7 (95% confidence interval [CI] 46.0–47.3) per 1000 person-years. Incidence rates increased with higher cumulative glucocorticoid prednisolone-equivalent dose, from 44.4 per 1000 person-years in periods of nonuse to 45.3 per… Continue reading Open Access Oral #glucocorticoids and incidence of #hypertension in people with chronic inflammatory diseases: a population-based cohort study
Blood #pressure in frail older adults: associations with #cardiovascular outcomes and all-cause mortality
Blood pressure (BP) management in frail older people is challenging. An randomised controlled trial of largely non-frail older people found cardiovascular and mortality benefit with systolic (S) BP target <120 mmHg. However, all-cause mortality by attained BP in routine care in frail adults aged above 75 is unclear.. ..Risks of cardiovascular outcomes increased with SBPs… Continue reading Blood #pressure in frail older adults: associations with #cardiovascular outcomes and all-cause mortality
Long #Working Hours and the Prevalence of Masked and Sustained #Hypertension
Previous studies on the effect of long working hours on blood pressure have shown inconsistent results. Mixed findings could be attributable to limitations related to blood pressure measurement and the lack of consideration of masked hypertension.. Ambulatory blood pressure was defined as the mean of the next readings recorded every 15 minutes during daytime working… Continue reading Long #Working Hours and the Prevalence of Masked and Sustained #Hypertension
Association of Isolated Diastolic #Hypertension as Defined by the 2017 ACC/AHA Blood Pressure Guideline With Incident Cardiovascular Outcomes
..the definition of hypertension was lowered from a blood pressure (BP) of greater than or equal to 140/90 to greater than or equal to 130/80 mm Hg. The new diastolic BP threshold of 80 mm Hg was recommended based on expert opinion and changes the definition of isolated diastolic hypertension (IDH). atherosclerotic cardiovascular disease (ASCVD)… Continue reading Association of Isolated Diastolic #Hypertension as Defined by the 2017 ACC/AHA Blood Pressure Guideline With Incident Cardiovascular Outcomes
Estimated #Stroke-Free Survival of #Folic Acid Therapy for Hypertensive Adults
The CSPPT (China Stroke Primary Prevention Trial) demonstrated a significant risk reduction of first stroke in hypertensive patients treated with enalapril plus folic acid compared with those with enalapril alone, but the lifetime stroke-free survival associated with the treatment is unknown.. ..Compared with enalapril alone, the enalapril plus folic acid treatment projected a mean lifetime… Continue reading Estimated #Stroke-Free Survival of #Folic Acid Therapy for Hypertensive Adults
Risk Factors for Heart #Failure in the Community: Differences by Age and Ejection #Fraction
..the comorbidities with the largest attributable risk of heart failure were arrhythmia (48.7%), hypertension (28.4%), and coronary artery disease (33.9%); together these explained 73.0% of heart failure. Similar associations were observed for patients with reduced and preserved ejection fraction, with the exception of hypertension. The risk of heart failure attributable to hypertension was 2-fold higher… Continue reading Risk Factors for Heart #Failure in the Community: Differences by Age and Ejection #Fraction
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