Statin therapy has been associated with increased risk of type 2 diabetes (T2D). We investigated the relationship between Low-Density Lipoprotein Cholesterol (LDL-C) plasma concentrations and incident T2D and evaluated the modifying effect of statin therapy in a large population-based cohort.MethodsIndividuals free of T2D and cardiovascular disease at baseline were followed longitudinally for the development of… Continue reading A six-year longitudinal study identifies a #statin -independent association between low LDL- #cholesterol and risk of type 2 #diabetes
Tag: cholesterol
#Cholesterol -lowering drug targets reduce risk of #dementia : Mendelian randomization and meta-analyses of 1 million individuals
We tested whether genetically proxied non-high-density lipoprotein cholesterol (non-HDL-C)–lowering drug targets reduce risk of all-cause dementia.METHODSWe included 1,091,775 individuals from three prospective general population cohorts with individual-level data and two consortia with summary-level data. We selected genetic variants within HMGCR, NPC1L1, PCSK9, ANGPTL4, LPL, and CETP associated with non-HDL-C. These variants were used as exposures… Continue reading #Cholesterol -lowering drug targets reduce risk of #dementia : Mendelian randomization and meta-analyses of 1 million individuals
High Density #Lipoproteins Associate with Age-Related #Macular Degeneration in the All of Us Research Program
OBJECTIVEExtracellular lipoprotein aggregation is a critical event in AMD pathogenesis. In this study, we sought to analyze associations between clinical and genetic-based factors related to lipoprotein metabolism and risk for age-related macular degeneration (AMD) in the All of Us research program.DESIGNCross-sectional retrospective data analysis.SUBJECTS5028 healthy and 2328 AMD patients from All of Us.METHODSParticipants with and… Continue reading High Density #Lipoproteins Associate with Age-Related #Macular Degeneration in the All of Us Research Program
#Inflammation, #Cholesterol, #Lipoprotein(a), and 30-Year #Cardiovascular Outcomes in Women
High-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels contribute to 5-year and 10-year predictions of cardiovascular risk and represent distinct pathways for pharmacologic intervention. More information about the usefulness of these biomarkers for predicting cardiovascular risk over longer periods of time in women is needed because early-life intervention represents an important risk-reduction… Continue reading #Inflammation, #Cholesterol, #Lipoprotein(a), and 30-Year #Cardiovascular Outcomes in Women
Effects of #Cocoa Consumption on #Cardiometabolic Risk Markers: Meta-Analysis of Randomized Controlled Trials
Abstract: Background: We conducted a systematic review and meta-analysis to examine the effect of dietary intake of cocoa on anthropometric measurements, lipid and glycemic profiles, and blood pressure levels in adults, with and without comorbidities. Methods: The databases used were MEDLINE (PubMed), EMBASE, Web of Science, Cochrane, LILACS, and SciELO. The eligible studies were randomized… Continue reading Effects of #Cocoa Consumption on #Cardiometabolic Risk Markers: Meta-Analysis of Randomized Controlled Trials
Gut #microbiome and metabolome profiling in Framingham heart study reveals #cholesterol-metabolizing bacteria
Multi-omic profiling in FHS reveals microbes and metabolites associated with CVD•Oscillibacter species are associated with decreased blood and stool cholesterol•Homology searches and molecular networking predict cholesterol enzymes and products•Oscillibacter species encode for conserved cholesterol-metabolizing enzymesSummaryAccumulating evidence suggests that cardiovascular disease (CVD) is associated with an altered gut microbiome. Our understanding of the underlying mechanisms has been hindered… Continue reading Gut #microbiome and metabolome profiling in Framingham heart study reveals #cholesterol-metabolizing bacteria
Enhanced SREBP2-driven #cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
The metabolic and signaling pathways regulating aggressive mesenchymal colorectal cancer (CRC) initiation and progression through the serrated route are largely unknown. Although relatively well characterized as BRAF mutant cancers, their poor response to current targeted therapy, difficult preneoplastic detection, and challenging endoscopic resection make the identification of their metabolic requirements a priority. Here, we demonstrate… Continue reading Enhanced SREBP2-driven #cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
Selected Soybean Varieties Regulate Hepatic LDL-Cholesterol Homeostasis Depending on Their Glycinin:β-Conglycinin Ratio
Clinical studies indicate that the consumption of soybean protein might reduce cholesterol and LDL levels preventing the development of atherosclerotic cardiovascular diseases. However, soybean variety can influence soybean protein profile and therefore affect soybean protein health-promoting properties. This study investigated the composition and effects of nineteen soybean varieties digested under simulated gastrointestinal conditions on hepatic… Continue reading Selected Soybean Varieties Regulate Hepatic LDL-Cholesterol Homeostasis Depending on Their Glycinin:β-Conglycinin Ratio
Effect of honey on cardiometabolic risk factors: a systematic review and meta-analysis
ContextExcess calories from free sugars are implicated in the epidemics of obesity and type 2 diabetes. Honey is a free sugar but is generally regarded as healthy.ObjectiveThe effect of honey on cardiometabolic risk factors was assessed via a systematic review and meta-analysis of controlled trials using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation)… Continue reading Effect of honey on cardiometabolic risk factors: a systematic review and meta-analysis
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