Highlights•Most eligible people offered participation in an aspirin trial accepted. •Among participants, most reported high (≥80%) adherence on a day-to-day basis. •No studies examined uptake and adherence in routine care. •Further research is needed to identify the barriers to using aspirin in practice. AbstractWe undertook a systematic review to synthesise the data on attitudes and… Continue reading Aspirin use for cancer prevention: A systematic review of public, patient and healthcare provider attitudes and adherence behaviours
Tag: cancer
#Nut consumption in association with overall mortality and recurrence/disease-specific mortality among long-term breast #cancer survivors
High nut consumption is associated with reduced total and certain cause-specific mortality in general populations. However, its association with cancer outcomes among long-term breast cancer survivors remains unknown. We examined the associations of nut consumption (including peanuts and tree nuts), assessed at 5-year postdiagnosis, with overall survival (OS) and disease-free survival (DFS) among 3449 long-term… Continue reading #Nut consumption in association with overall mortality and recurrence/disease-specific mortality among long-term breast #cancer survivors
Changes in #metabolic syndrome status are associated with altered risk of #pancreatic cancer: A nationwide cohort study
Background & AimsMetabolic syndrome (MetS) is reversible; however, the effect of changes in MetS status on pancreatic cancer risk is unknown. We aimed to investigate the effects of changes and persistence in MetS status on pancreatic cancer risk. MethodsThis nationwide cohort study included 8,203,492 adults without cancer who underwent two consecutive biennial health screenings provided… Continue reading Changes in #metabolic syndrome status are associated with altered risk of #pancreatic cancer: A nationwide cohort study
Impact of #diverticular disease on #prostate cancer risk among #hypertensive men
Prostate cancer (PCa) is a heterogenous disease with multiple etiological factors playing a role in its development. Recently, chronic and systemic inflammatory conditions such as inflammatory bowel disease were identified as key risk factors influencing its development. The study aimed to evaluate the relationship between diverticular disease (DD) (local and acute inflammation) and PCa. MethodsHypertensive… Continue reading Impact of #diverticular disease on #prostate cancer risk among #hypertensive men
Dietary #spinach reshapes the gut #microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics
ABSTRACTComplex interrelationships govern the dynamic interactions between gut microbes, the host, and exogenous drivers of disease outcome. A multi-omics approach to cancer prevention by spinach (SPI) was pursued for the first time in the polyposis in rat colon (Pirc) model. SPI fed for 26 weeks (10% w/w, freeze-dried in the diet) exhibited significant antitumor efficacy… Continue reading Dietary #spinach reshapes the gut #microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics
#Antibiotics Use and Subsequent Risk of #Colorectal Cancer: A Swedish Nationwide Population-Based Study
Antibiotics use may increase colorectal cancer (CRC) risk by altering the gut microbiota, with suggestive evidence reported. Our study aims to investigate antibiotics use in relation to subsequent CRC risk. MethodsThis is a nationwide, population-based study with a matched case-control design (first primary CRC cases and 5 matched, cancer-free controls). Complete-population data, extracted from Swedish… Continue reading #Antibiotics Use and Subsequent Risk of #Colorectal Cancer: A Swedish Nationwide Population-Based Study
The association between occupational #asbestos exposure with the risk of incidence and mortality from #prostate #cancer: a systematic review and meta-analysis
There is conflicting evidence on the association between asbestos exposure and prostate cancer (PCa). Two recent meta-analyses have claimed that exposure is associated with increased PCa incidence and mortality, but they suffer from some methodological flaws. Given the potential importance of this research question, we aimed to perform a methodologically sound systematic review and meta-analysis… Continue reading The association between occupational #asbestos exposure with the risk of incidence and mortality from #prostate #cancer: a systematic review and meta-analysis
The #sulfur microbial diet is associated with increased risk of early-onset #colorectal cancer precursors
Diet may contribute to the increasing incidence of colorectal cancer (CRC) before age 50 (early-onset CRC). Microbial metabolism of dietary sulfur produces hydrogen sulfide (H2S), a gastrointestinal carcinogen that cannot be easily measured at scale. As a result, evidence supporting its role in early neoplasia is lacking. MethodsWe evaluated long-term adherence to the sulfur microbial… Continue reading The #sulfur microbial diet is associated with increased risk of early-onset #colorectal cancer precursors
#EGFR activation limits the response of #liver cancer to lenvatinib
Hepatocellular carcinoma (HCC)—the most common form of liver cancer—is an aggressive malignancy with few effective treatment options1. Lenvatinib is a small-molecule inhibitor of multiple receptor tyrosine kinases that is used for the treatment of patients with advanced HCC, but this drug has only limited clinical benefit2. Here, using a kinome-centred CRISPR–Cas9 genetic screen, we show… Continue reading #EGFR activation limits the response of #liver cancer to lenvatinib
2 Medical News 