Risk Factors and Incidence of Gastric Cancer After Detection of Helicobacter pylori Infection: A Large Cohort StudyShria KumarDavid C. MetzSusan EllenbergDavid E. KaplanDavid S. Goldberg Published:October 22, 2019DOI:https://doi.org/10.1053/j.gastro.2019.10.019PlumX MetricsBackground & AimsNearly all studies of gastric adenocarcinoma in the United States have relied on national cancer databases, which do not include data on Helicobacter pylori infection, the most well-known risk factor… Continue reading Risk Factors and Incidence of #Gastric #Cancer After Detection of #Helicobacter pylori Infection: A Large Cohort Study
Tag: cancer
Association of #glycaemic index and glycaemic load with type 2 #diabetes, #cardiovascular disease, #cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
There is debate over whether the glycaemic index of foods relates to chronic disease. We aimed to assess the associations between glycaemic index (GI) and glycaemic load (GL) and type 2 diabetes, cardiovascular disease, diabetes-related cancers, and all-cause mortality.MethodsWe did a meta-analysis of large cohorts (≥100 000 participants) identified from the Richard Doll Consortium. We searched… Continue reading Association of #glycaemic index and glycaemic load with type 2 #diabetes, #cardiovascular disease, #cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
Post-diagnostic #multivitamin supplement use and #colorectal cancer survival: A prospective cohort study
AbstractBackgroundUse of multivitamin supplements has been associated with lower incidence of colorectal cancer (CRC). However, its influence on CRC survival remains unknown.MethodsAmong 2424 patients with stage I–III CRC who provided detailed information about multivitamin supplements in the Nurses’ Health Study and Health Professionals Follow-up Study, the authors calculated multivariable hazard ratios (HRs) of multivitamin supplements… Continue reading Post-diagnostic #multivitamin supplement use and #colorectal cancer survival: A prospective cohort study
#Prostate Safety Events During #Testosterone Replacement Therapy in Men With HypogonadismA Randomized Clinical Trial
Importance The effect of testosterone replacement therapy (TRT) on the risk of prostate cancer and other adverse prostate events is unknown.Objective To compare the effect of TRT vs placebo on the incidences of high-grade prostate cancers (Gleason score ≥4 + 3), any prostate cancer, acute urinary retention, invasive prostate procedures, and pharmacologic treatment for lower urinary tract… Continue reading #Prostate Safety Events During #Testosterone Replacement Therapy in Men With HypogonadismA Randomized Clinical Trial
Enhanced SREBP2-driven #cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
The metabolic and signaling pathways regulating aggressive mesenchymal colorectal cancer (CRC) initiation and progression through the serrated route are largely unknown. Although relatively well characterized as BRAF mutant cancers, their poor response to current targeted therapy, difficult preneoplastic detection, and challenging endoscopic resection make the identification of their metabolic requirements a priority. Here, we demonstrate… Continue reading Enhanced SREBP2-driven #cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
Consumption of ultra-processed #foods and risk of multimorbidity of #cancer and #cardiometabolic diseases: a multinational cohort study
It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic diseases in an individual among first cancer at any site, cardiovascular disease, and… Continue reading Consumption of ultra-processed #foods and risk of multimorbidity of #cancer and #cardiometabolic diseases: a multinational cohort study
The #sex gap in #bladder cancer survival — a missing link in bladder #cancer care?
The differences in bladder cancer outcomes between the sexes has again been highlighted. Uncommon among cancers, bladder cancer outcomes are notably worse for women than for men. Furthermore, bladder cancer is three to four times more common among men than among women. Factors that might explain these sex differences include understanding the importance of haematuria… Continue reading The #sex gap in #bladder cancer survival — a missing link in bladder #cancer care?
Detection of high-risk #polyps at screening colonoscopy indicates risk for #liver and #biliary #cancer death
Hepatobiliary cancers share risk factors with colorectal cancer (CRC), but there are no combined screening programs for these conditions.AimsThe aim of this study was to assess whether patients with high-risk colonic polyps are more likely to die from liver related tumors than patients with a negative colonoscopy.MethodsIn this retrospective analysis of mortality data, Austrian screening… Continue reading Detection of high-risk #polyps at screening colonoscopy indicates risk for #liver and #biliary #cancer death
Effect of Vitamin #D Supplements on Relapse or Death in a p53-Immunoreactive Subgroup With #Digestive Tract Cancer
Recent meta-analyses of randomized clinical trials found that daily vitamin D3 supplementation had beneficial effects on cancer mortality, although the results are still controversial.Objective To examine whether vitamin D supplementation reduces the risk of relapse or death in a supgroup of patients with digestive tract cancer who were p53 immunoreactive.Design, Setting, and Participants This was a post… Continue reading Effect of Vitamin #D Supplements on Relapse or Death in a p53-Immunoreactive Subgroup With #Digestive Tract Cancer
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