Clinical and preclinical studies established that supplementing diets with ω3 polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic steatohepatitis (NASH) but molecular underpinnings of this action were elusive. Herein, we used multi-omic network analysis that unveiled critical molecular pathways involved in ω3 PUFA effects in a preclinical mouse model of western diet induced… Continue reading Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis
Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red #wine #headaches
The consumption of red wine induces headaches in some subjects who can drink other alcoholic beverages without suffering. The cause for this effect has been attributed to a number of components, often the high level of phenolics in red wine, but a mechanism has been elusive. Some alcohol consumers exhibit flushing and experience headaches, and… Continue reading Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red #wine #headaches
Consumption of ultra-processed #foods and risk of multimorbidity of #cancer and #cardiometabolic diseases: a multinational cohort study
It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic diseases in an individual among first cancer at any site, cardiovascular disease, and… Continue reading Consumption of ultra-processed #foods and risk of multimorbidity of #cancer and #cardiometabolic diseases: a multinational cohort study
The Potential Role of Vitamin #E in Managing Non-Alcoholic Fatty #Liver Disease: Insights from Japan’s Aichi Medical University Study
Non-Alcoholic Fatty Liver Disease (NAFLD) has emerged as a significant public health concern, affecting millions of individuals worldwide. Characterized by the accumulation of fat in the liver without excessive alcohol consumption, NAFLD can progress to more severe conditions, such as non-alcoholic steatohepatitis (NASH) and cirrhosis. While lifestyle modifications remain a cornerstone in managing NAFLD, recent… Continue reading The Potential Role of Vitamin #E in Managing Non-Alcoholic Fatty #Liver Disease: Insights from Japan’s Aichi Medical University Study
Why Do We Get Fever?
Fever, or pyrexia, refers to an increase in body temperature beyond its normal range. While our temperature may vary slightly during the course of the day (by not more than 1.0°C – 1.5 °C, usually higher in the evening than in the morning) and due to other factors such as exercise, menstrual cycle phase, hot… Continue reading Why Do We Get Fever?
#Circadian disturbances and #frailty risk in #older adults
Frailty is characterized by diminished resilience to stressor events. It is associated with adverse future health outcomes and impedes healthy aging. The circadian system orchestrates ~24-h rhythms in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an important role in many age-related health consequences. We investigated prospective associations of circadian… Continue reading #Circadian disturbances and #frailty risk in #older adults
The psychophysiology of Mastermind: Characterizing response times and #blinking in a high-stakes television game show
Television game shows have proven to be a valuable resource for studying human behavior under conditions of high #stress and high stakes. However, previous work has focused mostly on choices—ignoring much of the rich visual information that is available on screen. Here, we take a first step to extracting more of this information by investigating… Continue reading The psychophysiology of Mastermind: Characterizing response times and #blinking in a high-stakes television game show
Lower serum #testosterone is associated with increased likelihood of #arthritis
Studies have suggested that serum testosterone levels may be strongly correlated with the pathogenesis of arthritis. Therefore, the aim of this study was to assess the relationship between serum testosterone levels and arthritis in US adults using the National Health and Nutrition Examination Survey (NHANES). We used the database from NHANES, 2013–2016 to perform a… Continue reading Lower serum #testosterone is associated with increased likelihood of #arthritis
Effect of Dietary #Sodium on Blood #PressureA Crossover Trial
Dietary sodium recommendations are debated partly due to variable blood pressure (BP) response to sodium intake. Furthermore, the BP effect of dietary sodium among individuals taking antihypertensive medications is understudied.Objectives To examine the distribution of within-individual BP response to dietary sodium, the difference in BP between individuals allocated to consume a high- or low-sodium diet first,… Continue reading Effect of Dietary #Sodium on Blood #PressureA Crossover Trial
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