BackgroundThere is debate over whether the glycaemic index of foods relates to chronic disease. We aimed to assess the associations between glycaemic index (GI) and glycaemic load (GL) and type 2 diabetes, cardiovascular disease, diabetes-related cancers, and all-cause mortality.MethodsWe did a meta-analysis of large cohorts (≥100 000 participants) identified from the Richard Doll Consortium. We searched… Continue reading Association of #glycaemic index and glycaemic load with type 2 #diabetes, cardiovascular disease, cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
#Metformin and Its Benefits for Various Diseases
Metformin is a widely used biguanide drug due to its safety and low cost. It has been used for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability to decrease plasma glucose levels. Over time, different uses of metformin were discovered, and the benefits of metformin for… Continue reading #Metformin and Its Benefits for Various Diseases
Association between #sinusitis and incident #rheumatic diseases: a population-based study
To determine whether antecedent sinusitis is associated with incident rheumatic disease.Methods This population-based case–control study included all individuals meeting classification criteria for rheumatic diseases between 1995 and 2014. We matched three controls to each case on age, sex and length of prior electronic health record history. The primary exposure was presence of sinusitis, ascertained by diagnosis… Continue reading Association between #sinusitis and incident #rheumatic diseases: a population-based study
Chronic Effects of Static #Stretching Exercises on Muscle #Strength and Power in Healthy Individuals Across the Lifespan: A Systematic Review with Multi-level Meta-analysis
The current literature on the chronic effects of static stretching (SS) exercises on muscle strength and power is unclear and controversial.ObjectiveWe aimed to examine the chronic effects of SS exercises on muscle strength and power as well as flexibility in healthy individuals across the lifespan.DesignSystematic review with meta-analysis of (randomized) controlled trials.Data SourcesA systematic literature… Continue reading Chronic Effects of Static #Stretching Exercises on Muscle #Strength and Power in Healthy Individuals Across the Lifespan: A Systematic Review with Multi-level Meta-analysis
Adherence to #Mediterranean diet is inversely associated with #depressive symptoms in older women: findings from the NutBrain Study
Data on the association of the Mediterranean diet with depressive symptoms in older people at high risk of depression are scarce. This study aimed to investigate the cross-sectional association of the adherence to the Mediterranean diet and its components with depressive symptoms in the Italian NutBrain cohort of older men and women. A total of… Continue reading Adherence to #Mediterranean diet is inversely associated with #depressive symptoms in older women: findings from the NutBrain Study
Association of #glycaemic index and glycaemic load with type 2 #diabetes, #cardiovascular disease, #cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
There is debate over whether the glycaemic index of foods relates to chronic disease. We aimed to assess the associations between glycaemic index (GI) and glycaemic load (GL) and type 2 diabetes, cardiovascular disease, diabetes-related cancers, and all-cause mortality.MethodsWe did a meta-analysis of large cohorts (≥100 000 participants) identified from the Richard Doll Consortium. We searched… Continue reading Association of #glycaemic index and glycaemic load with type 2 #diabetes, #cardiovascular disease, #cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
#Light stimulation of mitochondria reduces blood #glucose levels
Mitochondria regulate metabolism, but solar light influences its rate. Photobiomodulation (PBM) with red light (670 nm) increases mitochondrial membrane potentials and adenosine triphosphate production and may increase glucose demand. Here we show, with a glucose tolerance test, that PBM of normal subjects significantly reduces blood sugar levels. A 15 min exposure to 670 nm light reduced the degree… Continue reading #Light stimulation of mitochondria reduces blood #glucose levels
Vitamin #E intake is inversely associated with #NAFLD measured by liver ultrasound transient elastography
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, whose severe form is associated with oxidative stress. Vitamin E as an antioxidant has a protective potential in NAFLD. Whether dietary intake of vitamin E, supplementary vitamin E use, and total vitamin E have a preventive effect on NAFLD requires investigation.… Continue reading Vitamin #E intake is inversely associated with #NAFLD measured by liver ultrasound transient elastography
Downregulation of the kidney #glucagon receptor, essential for #renal function and systemic homeostasis, contributes to chronic kidney disease
The glucagon receptor (GCGR) in the kidney is expressed in nephron tubules. In humans and animal models with chronic kidney disease, renal GCGR expression is reduced. However, the role of kidney GCGR in normal renal function and in disease development has not been addressed. Here, we examined its role by analyzing mice with constitutive or conditional kidney-specific loss of the Gcgr. Adult renal Gcgr knockout mice exhibit metabolic dysregulation and a functional… Continue reading Downregulation of the kidney #glucagon receptor, essential for #renal function and systemic homeostasis, contributes to chronic kidney disease
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