Chronic musculoskeletal pain (CMP), a prevalent and heterogeneous condition characterized by persistent pain in various body parts, is a leading cause of disability worldwide and greatly affects a patient’s brain. Apart from experiencing pain, older adults with CMP also have accelerated cognitive decline and higher dementia risk with limited understanding of biological mechanism underlying the… Continue reading Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
Scanning #ultrasound-mediated memory and functional improvements do not require #amyloid-β reduction
A prevalent view in treating age-dependent disorders including Alzheimer’s disease (AD) is that the underlying amyloid plaque pathology must be targeted for cognitive improvements. In contrast, we report here that repeated scanning ultrasound (SUS) treatment at 1 MHz frequency can ameliorate memory deficits in the APP23 mouse model of AD without reducing amyloid-β (Aβ) burden. Different… Continue reading Scanning #ultrasound-mediated memory and functional improvements do not require #amyloid-β reduction
Risk Factors and Incidence of #Gastric #Cancer After Detection of #Helicobacter pylori Infection: A Large Cohort Study
Risk Factors and Incidence of Gastric Cancer After Detection of Helicobacter pylori Infection: A Large Cohort StudyShria KumarDavid C. MetzSusan EllenbergDavid E. KaplanDavid S. Goldberg Published:October 22, 2019DOI:https://doi.org/10.1053/j.gastro.2019.10.019PlumX MetricsBackground & AimsNearly all studies of gastric adenocarcinoma in the United States have relied on national cancer databases, which do not include data on Helicobacter pylori infection, the most well-known risk factor… Continue reading Risk Factors and Incidence of #Gastric #Cancer After Detection of #Helicobacter pylori Infection: A Large Cohort Study
Gut #microbiome and metabolome profiling in Framingham heart study reveals #cholesterol-metabolizing bacteria
Multi-omic profiling in FHS reveals microbes and metabolites associated with CVD•Oscillibacter species are associated with decreased blood and stool cholesterol•Homology searches and molecular networking predict cholesterol enzymes and products•Oscillibacter species encode for conserved cholesterol-metabolizing enzymesSummaryAccumulating evidence suggests that cardiovascular disease (CVD) is associated with an altered gut microbiome. Our understanding of the underlying mechanisms has been hindered… Continue reading Gut #microbiome and metabolome profiling in Framingham heart study reveals #cholesterol-metabolizing bacteria
Early Use of #Erenumab vs Nonspecific Oral #Migraine PreventivesThe APPRAISE Randomized Clinical Trial
Importance Patients with migraine often cycle through multiple nonspecific preventive medications due to poor tolerability and/or inadequate efficacy leading to low adherence and increased disease burden.Objective To compare the efficacy, tolerability, patient adherence, and patient satisfaction between erenumab and nonspecific oral migraine preventive medications (OMPMs) in patients with episodic migraine (EM) who had previously failed 1 or… Continue reading Early Use of #Erenumab vs Nonspecific Oral #Migraine PreventivesThe APPRAISE Randomized Clinical Trial
#Sarcopenia and Sarcopenic #Obesity and Mortality Among Older People
Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.Objective To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.Design, Setting, and Participants This large-scale,… Continue reading #Sarcopenia and Sarcopenic #Obesity and Mortality Among Older People
One #Avocado per Day as Part of Usual Intake Improves #Diet Quality: Exploratory Results from a Randomized Controlled Trial
Few clinical trials have evaluated diet quality change as a predictor of intervention effectiveness.ObjectivesThe aim of this study was to examine changes in the Healthy Eating Index (HEI)-2015 after a food-based intervention, and assess the associations between HEI-2015 change and intervention effects on cardiometabolic risk–related outcomes.MethodsThe Habitual Diet and Avocado Trial was a 26-wk, multicenter,… Continue reading One #Avocado per Day as Part of Usual Intake Improves #Diet Quality: Exploratory Results from a Randomized Controlled Trial
Longitudinal Associations Between #Optimism and Objective Measures of #Physical Functioning in Women
Identifying factors contributing to sustained physical functioning is critical for the health and well-being of the aging population, especially as physical functioning may precede and predict subsequent health outcomes. Prior work suggests optimism may protect health, but less is known about the association between optimism and objective physical functioning measures as individuals age.Objective To evaluate the… Continue reading Longitudinal Associations Between #Optimism and Objective Measures of #Physical Functioning in Women
Opposing diet, #microbiome, and metabolite mechanisms regulate inflammatory #bowel disease in a genetically susceptible host
Highlights•Dietary fiber-deprived gut microbiota elicits lethal colitis in Il10−/− mice•Mucolytic gut bacteria weaken mucus and drive inflammatory immune responses•Alterations in bacterial IgA coating and increased NK cells precede inflammation•Exclusive enteral nutrition promotes bacterial isobutyrate, reducing inflammationSummaryInflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and are increasing in industrialized populations. Combined with… Continue reading Opposing diet, #microbiome, and metabolite mechanisms regulate inflammatory #bowel disease in a genetically susceptible host
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