Background: The COVID-19 pandemic adversely affected the severity and prognosis of patients with acute myocardial infarction (MI) caused by atherothrombosis (type 1 MI). The effect, if any, of COVID-19 vaccination and natural SARS-CoV2 serologic immunity in these patients is unclear. Our aim was to analyze the association between the severity and outcome of patients with type… Continue reading Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
Brazil #Nut (Bertholletia excelsa H.B.K.) Consumption in Energy-Restricted Intervention Decreases Proinflammatory Markers and #Intestinal Permeability of Women with Overweight/Obesity: A Controlled Trial (Brazilian Nuts Study)
BackgroundObesity is associated with low-grade inflammation and increased intestinal permeability (IP). The Brazil nut (BN) (Bertholletia excelsa H.B.K.) appears to be a promising dietary intervention to control inflammation by enhancing antioxidant defenses.ObjectivesWe aimed to assess the effect of daily BN consumption on inflammatory biomarkers and IP in the context of an energy-restricted intervention. Furthermore, we… Continue reading Brazil #Nut (Bertholletia excelsa H.B.K.) Consumption in Energy-Restricted Intervention Decreases Proinflammatory Markers and #Intestinal Permeability of Women with Overweight/Obesity: A Controlled Trial (Brazilian Nuts Study)
Modifiers of the Effects of Vitamin #D Supplementation on #Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
The inconsistent findings concerning the effects of vitamin D supplementation on cardiometabolic risk factors and the large heterogeneity in the published literature call for further research to identify sources of heterogeneity and potential effect modifiers. We performed a meta-analysis of randomized controlled trials (RCTs) published until March 2024 that reported estimates for the effects of… Continue reading Modifiers of the Effects of Vitamin #D Supplementation on #Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
Body #Roundness Index Trajectories and the Incidence of #Cardiovascular Disease: Evidence From the China Health and Retirement Longitudinal Study
Several previous cross‐sectional studies suggested that body roundness index (BRI) may be associated with cardiovascular disease (CVD). However, the association should be further validated. Our study aimed to assess the association of the BRI trajectories with CVD among middle‐aged and older Chinese people in a longitudinal cohort.Methods and ResultsA total of 9935 participants from the… Continue reading Body #Roundness Index Trajectories and the Incidence of #Cardiovascular Disease: Evidence From the China Health and Retirement Longitudinal Study
Risk of #Dementia Diagnosis After Injurious #Falls in Older Adults
Importance Emerging evidence suggests that mild cognitive impairment, which is a precursor to Alzheimer disease and related dementias (ADRD), places older adults at increased risk for falls. However, the risk that an older adult develops dementia after experiencing a fall is unknown.Objective To determine the risk of new ADRD diagnosis after a fall in older… Continue reading Risk of #Dementia Diagnosis After Injurious #Falls in Older Adults
Time-Restricted Eating in Adults With #Metabolic Syndrome: A Randomized Controlled Trial
Background:Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.Objective:To determine the effects of TRE as a lifestyle intervention combined with current standard-of-care treatments on cardiometabolic health in adults with metabolic syndrome.Design:Randomized controlled trial. (ClinicalTrials.gov: NCT04057339)Setting:Clinical research institute.Participants:Adults with metabolic syndrome including elevated… Continue reading Time-Restricted Eating in Adults With #Metabolic Syndrome: A Randomized Controlled Trial
#Metformin decelerates #aging clock in male monkeys
Highlights•Metformin prevents brain atrophy, elevating cognitive function in aged male primates.Metformin slows the pace of aging across diverse male primate tissues•Metformin counterparts neuronal aging, delivering geroprotection via Nrf2 in male primatesSummaryIn a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The… Continue reading #Metformin decelerates #aging clock in male monkeys
Comparative effects of drug interventions for the acute management of #migraine episodes in adults: systematic review and network meta-analysis
Objective To compare all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults.Design Systematic review and network meta-analysis.Data sources Cochrane Central Register of Controlled Trials, Medline, Embase, ClinicalTrials.gov, EU Clinical Trials Register, WHO International Clinical Trials Registry Platform, as well as websites of regulatory agencies and pharmaceutical companies without language restrictions until… Continue reading Comparative effects of drug interventions for the acute management of #migraine episodes in adults: systematic review and network meta-analysis
Prevalence of Critical Errors and Insufficient Peak Inspiratory Flow in Patients Hospitalized With #COPD in a Department of General Internal Medicine: A Cross-Sectional Study
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and the third leading cause of mortality worldwide.1 The pharmaceutical treatment of COPD relies mainly on the administration of medications via inhalation. However, the effectiveness of these treatments is very often hampered by the suboptimal utilization of inhalers, which may arise due to errors in… Continue reading Prevalence of Critical Errors and Insufficient Peak Inspiratory Flow in Patients Hospitalized With #COPD in a Department of General Internal Medicine: A Cross-Sectional Study
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