Highlights• Sugar-sweetened beverage intake was associated with nine gut bacteria abundances• These bacteria were correlated with aromatic and branched-chain amino acid metabolites• These bacteria were correlated with glycerophospholipids• These gut microbial metabolites were associated with diabetes risk SummaryNo population-based studies examined gut microbiota and related metabolites associated with sugar-sweetened beverage (SSB) intake among US adults.… Continue reading #Sugar-sweetened beverage intake, gut #microbiota, circulating metabolites, and #diabetes risk in Hispanic Community Health Study/Study of Latinos
Subcellular #NAD+ pools are interconnected and buffered by mitochondrial NAD+
The coenzyme NAD+ is consumed by signalling enzymes, including poly-ADP-ribosyltransferases (PARPs) and sirtuins. Ageing is associated with a decrease in cellular NAD+ levels, but how cells cope with persistently decreased NAD+ concentrations is unclear. Here, we show that subcellular NAD+ pools are interconnected, with mitochondria acting as a rheostat to maintain NAD+ levels upon excessive… Continue reading Subcellular #NAD+ pools are interconnected and buffered by mitochondrial NAD+
The influence of mechanical #ventilation and portable air cleaners upon aerosol spread in a hospital outpatients clinic
The SARS-CoV-2 global pandemic has highlighted the risk of nosocomial infections of airborne viruses to patient populations around the world. Increased use of mechanical ventilation and portable air cleaners (PACs) have been suggested as methods to mitigate this risk, but the introduction of new air flows to indoor areas can have complex and potentially unforeseen… Continue reading The influence of mechanical #ventilation and portable air cleaners upon aerosol spread in a hospital outpatients clinic
‘Experimentum Crucis’: Hauksbee the Younger’s ‘decisive experiment’ for comparing the ‘Safety and Efficacy’ of new medicines (1743)
AbstractIn 1743 Francis Hauksbee the Younger published a proposal for an ‘Experimentum Crucis’ (‘decisive experiment’) to compare his own medication for venereal disease with other treatments. Previously he had sought to replicate the methods of James Jurin FRS, who published outcomes from inoculation against smallpox in the 1720s. By seeking to record outcomes (‘Safety and… Continue reading ‘Experimentum Crucis’: Hauksbee the Younger’s ‘decisive experiment’ for comparing the ‘Safety and Efficacy’ of new medicines (1743)
Association of rapid eye movement #sleep latency with multimodal biomarkers of #Alzheimer’s disease
Sleep disturbances are associated with Alzheimer's disease (AD) and Alzheimer's disease and related dementias (ADRD), but the relationship between sleep architecture, particularly rapid eye movement (REM) sleep, and AD/ADRD biomarkers remains unclear.METHODSWe enrolled 128 adults (64 with Alzheimer's disease, 41 with mild cognitive impairment [MCI], and 23 with normal cognition [NC]), mean age 70.8 ±… Continue reading Association of rapid eye movement #sleep latency with multimodal biomarkers of #Alzheimer’s disease
Long-Term Effect of Intensive vs Standard Blood #Pressure Control on Mild Cognitive Impairment and Probable #Dementia in SPRINT
Background and ObjectivesThe Systolic Blood Pressure Intervention Trial suggested that intensive lowering of systolic blood pressure (SBP) decreases the risk of developing dementia. However, an insufficient number of probable dementia cases stemming from the trial's early termination made results inconclusive. The goal of this study was to estimate the effect of intensive vs standard SBP… Continue reading Long-Term Effect of Intensive vs Standard Blood #Pressure Control on Mild Cognitive Impairment and Probable #Dementia in SPRINT
Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Nearly 3% of adults have attention-deficit and hyperactivity disorder (ADHD), although in the UK, most are undiagnosed. Adults with ADHD on average experience poorer educational and employment outcomes, worse physical and mental health and are more likely to die prematurely. No studies have yet used mortality data to examine the life expectancy deficit experienced by… Continue reading Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Can #carbonated water support weight loss?
Background Carbonated water has been reported to induce satiety, gastric motility and lower serum glucose concentrations, but the mechanisms remain unclear.Methods This report explores the physiological effects of carbonated water, referencing a study published in 2004 on the mechanisms of hypoglycaemia induced by haemodialysis.Results Upon consumption of carbonated water, carbon dioxide (CO2) is absorbed into… Continue reading Can #carbonated water support weight loss?
#Dapagliflozin plus calorie restriction for remission of type 2 #diabetes: multicentre, double blind, randomised, placebo controlled trial
Objective To assess the effect of dapagliflozin plus calorie restriction on remission of type 2 diabetes.Design Multicentre, double blind, randomised, placebo controlled trial.Setting 16 centres in mainland China from 12 June 2020 to 31 January 2023.Participants 328 patients with type 2 diabetes aged 20-70 years, with body mass index >25 and diabetes duration of <6… Continue reading #Dapagliflozin plus calorie restriction for remission of type 2 #diabetes: multicentre, double blind, randomised, placebo controlled trial
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