Polygenic risk was associated with increased odds of incident depression, and physical activity showed a protective effect of similar but opposite magnitude, even after adjusting for BMI, employment status, educational attainment, and prior depression. Higher levels of physical activity were associated with reduced odds of incident depression across all levels of genetic vulnerability, even among… Continue reading Physical #activity offsets genetic risk for incident #depression assessed via electronic health records in a biobank cohort study
Results of a 6-week treatment with 10 mg prednisolone in patients with hand #osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial
..The mean change between baseline and week 6 on VAS-reported finger pain was −21·5 (SD 21·7) in the prednisolone group and −5·2 (24·3) in the placebo group, with a mean between-group difference (of prednisolone vs placebo) of −16·5 (95% CI −26·1 to −6·9; p=0·0007). The number of non-serious adverse events was similar between the groups.… Continue reading Results of a 6-week treatment with 10 mg prednisolone in patients with hand #osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial
Clinical presentation, treatment, and short-term outcomes of #lung injury associated with e-cigarettes or #vaping: a prospective observational cohort study
..33 (55%) of 60 were admitted to an intensive care unit (ICU). 53 (88%) of 60 patients presented with constitutional symptoms, 59 (98%) with respiratory symptoms, and 54 (90%) with gastrointestinal symptoms. 54 (90%) of 60 were given antibiotics and 57 (95%) were given steroids. Six (10%) of 60 patients were readmitted to an ICU… Continue reading Clinical presentation, treatment, and short-term outcomes of #lung injury associated with e-cigarettes or #vaping: a prospective observational cohort study
Effects of One Year of Vitamin #D and Marine #Omega-3 Fatty Acid Supplementation on Biomarkers of Systemic Inflammation in Older US Adults
..(VITAL) tested vitamin D (2000 IU/day) and/or n-3 FA (1 g/day) supplementation in a 2 × 2 factorial design among women ≥55 and men ≥50 years of age. Baseline characteristics were well balanced. In the active arms, 25-OH vitamin D rose 39% and n-3 FA rose 55% vs minimal change in placebo arms. Neither supplement… Continue reading Effects of One Year of Vitamin #D and Marine #Omega-3 Fatty Acid Supplementation on Biomarkers of Systemic Inflammation in Older US Adults
Taller people have increased risk for developing atrial #fibrillation
Researchers found that the risk for AFib climbed as one's height increased, with every one-inch increase in height translating to about a three percent increase in risk of Afib--independent of other clinical factors--as compared to those at average height (5 feet and 7 inches). "Our findings suggest it may be beneficial to incorporate height into… Continue reading Taller people have increased risk for developing atrial #fibrillation
The Association Between Perceived Electronic Health #Record Usability and Professional #Burnout Among US Physicians
To describe and benchmark physician-perceived electronic health record (EHR) usability as defined by a standardized metric of technology usability and evaluate the association with professional burnout among physicians. ..Mean ± SD SUS score was 45.9±21.9. A score of 45.9 is in the bottom 9% of scores across previous studies and categorized in the “not acceptable”… Continue reading The Association Between Perceived Electronic Health #Record Usability and Professional #Burnout Among US Physicians
#Aspirin for primary #prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups
..major adverse cardiovascular events (MACE) ..Aspirin use did not translate into a net clinical benefit adjusted for event-associated mortality risk (mean 0.034%; 95% CI, − 0.18 to 0.25%). There was an interaction for aspirin effect in three patient subgroups: (i) in patients under statin treatment, aspirin was associated with a 12% RRR of MACE (RR 0.88;… Continue reading #Aspirin for primary #prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups
Diagnosis of #osteoporosis in #statin-treated patients is dose-dependent
..There was a highly non-trivial dependence of statin dosage with the ORs of osteoporosis. Osteoporosis was underrepresented in low-dose statin treatment (0–10 mg per day), including lovastatin (OR: 0.39, CI 0.18 to 0.84, p<0.05), pravastatin (OR: 0.68, 95% CI 0.52 to 0.89, p<0.01), simvastatin (OR: 0.70, 95% CI 0.56 to 0.86, p<0.01) and rosuvastatin (OR: 0.69, 95% CI 0.55… Continue reading Diagnosis of #osteoporosis in #statin-treated patients is dose-dependent
In Vivo Assessment of #Retinal Biomarkers by Hyperspectral Imaging: Early Detection of #Alzheimer’s Disease
..The retina is a developmental extension of the brain and has been viewed as a window to evaluate AD-related pathology. ..Described herein is the utilization of our retinal hyperspectral imaging (rHSI) technique as a biomarker for identification of AD-related early pathological changes in the retina The underlying principle is Rayleigh light scattering, which is expected… Continue reading In Vivo Assessment of #Retinal Biomarkers by Hyperspectral Imaging: Early Detection of #Alzheimer’s Disease
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