.. A positive troponin result (that is, higher than the upper limit of normal) signified a 3.2 higher mortality hazard (95% confidence interval 3.1 to 3.2) over three years. Mortality varied noticeably with age, with a hazard ratio of 10.6 (8.5 to 13.3) in 18-29 year olds and 1.5 (1.4 to 1.6) in those older… Continue reading Association of #troponin level and age with #mortality in 250 000 patients: cohort study across five UK acute care centres
Short #Sleep Is Associated With Low Bone Mineral Density and #Osteoporosis in the Women’s Health Initiative
.. In adjusted linear regression models, women who reported sleeping 5 hours or less per night had on average 0.012 to 0.018 g/cm2 significantly lower BMD at all four sites compared with women who reported sleeping 7 hours per night (reference). In adjusted multinomial models, women reporting 5 hours or less per night had higher odds of low bone… Continue reading Short #Sleep Is Associated With Low Bone Mineral Density and #Osteoporosis in the Women’s Health Initiative
#Atopic eczema and #fracture risk in adults: A population-based cohort study
..Those with eczema had increased risk of hip (HR, 1.10; 99% CI, 1.06-1.14), pelvic (HR, 1.10; 99% CI, 1.02-1.19), spinal (HR, 1.18; 99% CI, 1.10-1.27), and wrist (HR, 1.07; 99% CI, 1.03,-1.11) fractures. We found no evidence of increased proximal humeral (HR, 1.06; 99% CI, 0.97-1.15) fracture risk. Fracture risk increased with increasing eczema severity,… Continue reading #Atopic eczema and #fracture risk in adults: A population-based cohort study
#Obesity Is the Most Common Risk Factor for Chronic #liver Disease
Obesity has been associated with liver fibrosis, yet guidelines do not emphasize it as an independent risk factor in which to have a high index of suspicion of advanced disease.. ..We prospectively recruited patients from a primary care practice with hazardous alcohol use and/or type 2 diabetes and/or obesity. Subjects were invited for a transient… Continue reading #Obesity Is the Most Common Risk Factor for Chronic #liver Disease
Relationship of #nutritional status, #inflammation, and serum #albumin levels during acute illness: A prospective study
Low serum albumin levels resulting from inflammation-induced capillary leakage or disease-related anorexia during acute illness are associated with poor outcomes. We investigated the relationship of nutritional status and inflammation with low serum albumin levels and 30-day mortality in a large cohort. ..Of 2,465 patients, 1,019 (41%) had low serum albumin levels (<34 g/L), 619 (25.1%)… Continue reading Relationship of #nutritional status, #inflammation, and serum #albumin levels during acute illness: A prospective study
Trends in Self-perceived #Weight Status, Weight Loss Attempts, and Weight Loss Strategies Among Adults in the United States, 1999-2006
..Increasing trends were observed in current measured BMI (difference, 1.20; 95% CI, 0.92-1.47; P for trend < .001), current measured weight (difference 2.77 kg; 95% CI, 1.92-3.61 kg; P for trend < .001), adjusted, self-reported, prior-year weight (difference, 2.36 kg; 95% CI, 1.52-3.21 kg; P for trend < .001), and the difference between measured and adjusted self-reported weight (difference 0.70 kg;… Continue reading Trends in Self-perceived #Weight Status, Weight Loss Attempts, and Weight Loss Strategies Among Adults in the United States, 1999-2006
Bedside #Optic Nerve Ultrasonography for Diagnosing Increased Intracranial #pressure: A Systematic Review and Meta-analysis
Optic nerve ultrasonography (optic nerve sheath diameter sonography) has been proposed as a noninvasive, quick method for diagnosing increased intracranial pressure ..Accuracy estimates were similar among studies stratified by patient age, operator specialty and training level, reference standard, sonographer blinding status, and cutoff value. The optimal cutoff for optic nerve sheath dilatation on ultrasonography was… Continue reading Bedside #Optic Nerve Ultrasonography for Diagnosing Increased Intracranial #pressure: A Systematic Review and Meta-analysis
Effect of Standard vs Intensive Blood #Pressure Control on the Risk of Recurrent #Stroke
The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated that a systolic blood pressure (BP) target less than 120 mm Hg was superior to less than 140 mm Hg for preventing vascular events. This trial excluded patients with prior stroke; therefore, the ideal BP target for secondary stroke prevention remains unknown. ..Throughout the overall follow-up period,… Continue reading Effect of Standard vs Intensive Blood #Pressure Control on the Risk of Recurrent #Stroke
Phase 2a randomized, placebo-controlled study of anti–IL-33 in peanut #allergy
IL-33, found in high levels in participants with allergic disorders, is thought to mediate allergic reactions. Etokimab, an anti–IL-33 biologic, has previously demonstrated a good safety profile and favorable pharmacodynamic properties in many clinical studies ..Efficacy measurements for active vs. placebo participants at the day 15 and 45 food challenge (tolerating a cumulative 275 mg… Continue reading Phase 2a randomized, placebo-controlled study of anti–IL-33 in peanut #allergy
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