..Compared with participants who remained at normal weight, those moving from the non-obese to obese category between young and middle adulthood had a 22% (hazard ratio 1.22, 95% confidence interval 1.11 to 1.33) and 49% (1.49, 1.21 to 1.83) higher risk of all cause mortality and heart disease mortality, respectively. Changing from obese to non-obese… Continue reading Weight change across adulthood in relation to all cause and cause specific #mortality: prospective cohort study
Impact of dietary #sucrose on #adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: liquid or solid
..Since in humans consumption of sugar-sweetened beverages has been widely implicated, we investigated whether the mode of ingestion (solid or liquid) had different impacts on body weight regulation and glucose homeostasis Consumption of sucrose-sweetened water, but not equivalent levels of solid sucrose, led to body fat gain in C57BL/6 mice. Glucose intolerance was positively correlated… Continue reading Impact of dietary #sucrose on #adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: liquid or solid
Effects of #tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic #brain injury (CRASH-3): a randomised, placebo-controlled trial
Tranexamic acid reduces surgical bleeding and decreases mortality in patients with traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury (TBI) and can cause brain herniation and death. We aimed to assess the effects of tranexamic acid in patients with TBI. The risk of head injury-related death reduced with tranexamic acid in patients… Continue reading Effects of #tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic #brain injury (CRASH-3): a randomised, placebo-controlled trial
Risk of Developing #Parkinson Disease in #Bipolar Disorder A Systematic Review and Meta-analysis
..Seven studies were eligible for inclusion and included 4 374 211 participants overall. A previous diagnosis of BD increased the likelihood of a subsequent diagnosis of idiopathic PD (odds ratio, 3.35; 95% CI, 2.00-5.60; I2 = 92%). A sensitivity analysis was performed by removing the studies that had a high risk of bias and also showed an increased risk… Continue reading Risk of Developing #Parkinson Disease in #Bipolar Disorder A Systematic Review and Meta-analysis
#Rivaroxaban Versus Vitamin K Antagonist in #Antiphospholipid Syndrome: A Randomized Noninferiority Trial
After 3 years of follow-up, recurrent thrombosis occurred in 11 patients (11.6%) in the rivaroxaban group and 6 (6.3%) in the VKA group (RR in the rivaroxaban group, 1.83 [95% CI, 0.71 to 4.76]). Stroke occurred more commonly in patients receiving rivaroxaban (9 events) than in those receiving VKAs (0 events) (corrected RR, 19.00 [CI,… Continue reading #Rivaroxaban Versus Vitamin K Antagonist in #Antiphospholipid Syndrome: A Randomized Noninferiority Trial
IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed #vascular barrier disruption
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with rising incidence. Diseased tissues are heavily vascularized ..Specifically, we show that inhibition of the IFN-γ response in vessels by endothelial-specific knockout of IFN-γ receptor 2 ameliorates experimentally induced colitis in mice. IFN-γ acts pathogenic by causing a breakdown of the vascular barrier through disruption of… Continue reading IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed #vascular barrier disruption
Nonpharmacological Interventions to Manage #Dementia Symptoms in Community-Dwelling Older Adults: A Cluster Randomized Controlled Trial
..exploring the effects of chair yoga (CY), compared to music intervention (MI) and chair-based exercise (CBE) in this population. Using a cluster randomized controlled trial (RCT), 3 community sites were randomly assigned 1:1:1 to CY, MI, or CBE. Participants attended twice-weekly 45-minute sessions for 12 weeks.. The CY group improved significantly in quality of life… Continue reading Nonpharmacological Interventions to Manage #Dementia Symptoms in Community-Dwelling Older Adults: A Cluster Randomized Controlled Trial
Long-Term #Dabigatran Treatment Delays #Alzheimer’s Disease Pathogenesis in the TgCRND8 Mouse Model
Results Anticoagulation with dabigatran prevented memory decline, cerebral hypoperfusion, and toxic fibrin deposition in the AD mouse brain. In addition, long-term dabigatran treatment significantly reduced the extent of amyloid plaques, oligomers, phagocytic microglia, and infiltrated T cells by 23.7%, 51.8%, 31.3%, and 32.2%, respectively. Dabigatran anticoagulation also prevented AD-related astrogliosis and pericyte alterations, and maintained… Continue reading Long-Term #Dabigatran Treatment Delays #Alzheimer’s Disease Pathogenesis in the TgCRND8 Mouse Model
Self-rated #walking pace and all-cause, #cardiovascular disease and cancer mortality: individual participant pooled analysis of 50 225 walkers from 11 population British cohorts
Walking pace is associated with risk of premature mortality. Among participants who did not experience an event in the first 2 years of follow-up (n=49 731), walking at an average or brisk/fast pace was associated with a reduced risk of all-cause (20% (95% CI 12% to 28%) and 24% (95% CI 13% to 33%), respectively) and CVD… Continue reading Self-rated #walking pace and all-cause, #cardiovascular disease and cancer mortality: individual participant pooled analysis of 50 225 walkers from 11 population British cohorts
2 Medical News 