This study aimed to investigate the association of metabolically healthy obesity (MHO) and other obesity phenotypes with electrocardiographic (#ECG) markers to understand the pathophysiological basis of increased cardiovascular disease (CVD) risk associated with these phenotypes metabolically healthy without obesity [MHNO; reference] Higher odds of prolonged PR interval, P‐wave duration, and QRS duration were observed among… Continue reading Association of #Obesity Phenotypes with Electrocardiographic Markers of Poor Outcomes in the General Population
Bilateral high-frequency hearing loss is associated with elevated blood #pressure and increased hypertension risk in occupational #noise exposed workers
..bilateral high-frequency hearing loss (BHFHL) Increasing years of occupational noise exposure and BHFHL were significantly associated with systolic and diastolic blood pressure increase (all P<0.001). The lineal trend was only significant in males, with adjusted ORs for hypertension gradually increasing with increasing years of occupational noise exposure (P<0.001). Furthermore, subjects having mild and high BHFHL… Continue reading Bilateral high-frequency hearing loss is associated with elevated blood #pressure and increased hypertension risk in occupational #noise exposed workers
Retrospective cohort study of individuals born with low #birthweight: implications for screening practices
Previous studies have established an association between low birthweight (LBW) and future kidney disease, but few have explored the progression of kidney dysfunction through the pediatric years leading up through adolescence and young adulthood ..glomerular filtration rate (#GFR) between LBW (<2500 grams) and normal birthweight (NBW) Age at follow-up ranged 1–26 years old. GFR was… Continue reading Retrospective cohort study of individuals born with low #birthweight: implications for screening practices
Atorvastatin in combination with conventional antimicrobial treatment of #Helicobacter pylori eradication: A randomized controlled clinical trial
..Considering the anti‐inflammatory and antibacterial effect of atorvastatin, the present study aimed at adding this agent to a four‐drug regimen in order to eradicate H. pylori. In the current study, 110 patients in the control group received a 14‐day regimen of amoxicillin, clarithromycin, bismuth, and esomeprazole, and 110 patients in the intervention group received 40… Continue reading Atorvastatin in combination with conventional antimicrobial treatment of #Helicobacter pylori eradication: A randomized controlled clinical trial
Effect of hormone replacement therapy on #atherogenic lipid profile in postmenopausal women
..Recent studies suggest that hormone replacement therapy (#HRT) is cardioprotective when initiated early after menopause, but the mechanisms involved are still unclear. One-hundred and forty postmenopausal women <70 years were included in EVTET and randomized either to active treatment (one tablet of 2 mg estradiol and 1 mg norethisterone acetate daily) (n = 71) or placebo (n = 69). Our study show… Continue reading Effect of hormone replacement therapy on #atherogenic lipid profile in postmenopausal women
A Screening Algorithm for Obstructive Sleep #Apnea in #Pregnancy
Obstructive sleep apnea (#OSA) is common in pregnancy and associated with maternal and fetal complications. Early detection of OSA may have important implications for maternal-fetal well-being. A screening tool combining several methods of assessment may better predict OSA among pregnant women compared with tools that rely solely on self-reported information.. Participants’ mean age was 27.4 ± 7.0… Continue reading A Screening Algorithm for Obstructive Sleep #Apnea in #Pregnancy
The bright side of dark: Exploring the positive effect of #narcissism on perceived stress through mental toughness
Previous research reported that Subclinical Narcissism (SN) may increase Mental #Toughness (MT) resulting in positive outcomes such as lower psychopathy, higher school grades and lower symptoms of depression. We conducted three studies (N = 364, 240 and 144 for studies 1, 2 and 3, respectively) to test a mediation model, which suggests that SN may increase MT… Continue reading The bright side of dark: Exploring the positive effect of #narcissism on perceived stress through mental toughness
Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant
Fecal microbiota transplantation (#FMT) is an emerging therapy for recurrent or refractory Clostridioides difficile infection and is being actively investigated for other conditions. We describe two patients in whom extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor… Continue reading Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant
Convergent evidence for predispositional effects of #brain gray matter volume on #alcohol consumption
Smaller right dorsolateral prefrontal cortex (DLPFC; i.e., middle and superior frontal gyri) and insula GMVs were associated with increased alcohol use across samples. Family-based and prospective longitudinal data suggest these associations are genetically-conferred and that DLPFC GMV prospectively predicts future use and initiation. Genomic risk for alcohol use was enriched in gene-sets preferentially expressed in… Continue reading Convergent evidence for predispositional effects of #brain gray matter volume on #alcohol consumption
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