Current guidelines suggest engaging in a minimum of 150 minutes of moderate to vigorous physical activity (MVPA) each week to support overall health. However, the effect of concentrated versus evenly distributed physical activity (PA) on health outcomes remains uncertain. This study aims to investigate the associations of “weekend warrior” pattern, where most MVPA is completed… Continue reading Association of Accelerometer‐Derived #Physical Activity Pattern With the Risks of All‐Cause, #Cardiovascular Disease, and Cancer Death
Lower slow wave #sleep and rapid eye movement sleep are associated with brain #atrophy of AD-vulnerable regions
Study Objectives:Sleep deficiency is associated with Alzheimer’s disease (AD) pathogenesis. We examined the association of sleep architecture with anatomical features observed in AD: (1) atrophy of hippocampus, entorhinal, inferior parietal, parahippocampal, precuneus, and cuneus regions (“AD-vulnerable regions”) and (2) cerebral microbleeds.Methods:In 270 participants of the Atherosclerosis Risk in the Communities Study, we examined the association… Continue reading Lower slow wave #sleep and rapid eye movement sleep are associated with brain #atrophy of AD-vulnerable regions
#Metal Concentrations in #Blood and #Cerebrospinal Fluid of Patients With #Arthroplasty Implants
Key PointsQuestion Do patients with large joint replacements have elevated levels of arthroplasty-relevant metals in blood and cerebrospinal fluid (CSF)?Findings This cross-sectional study with 204 patients found blood levels of cobalt, chromium, titanium, niobium, and zirconium to be significantly higher in patients with large joint replacements compared with arthroplasty-naive control participants. Cobalt levels in CSF… Continue reading #Metal Concentrations in #Blood and #Cerebrospinal Fluid of Patients With #Arthroplasty Implants
Postpartum Hormonal #Contraceptive Use and Risk of #Depression
AbstractImportance Hormonal contraceptive (HC) use is associated with depression. It is, however, unknown whether this is also true in the postpartum period when women have a heightened depression risk and are routinely offered HC treatment.Objective To examine whether HC initiation post partum is associated with the development of depression within 12 months post partum.Design, Setting,… Continue reading Postpartum Hormonal #Contraceptive Use and Risk of #Depression
High- #salt #diet drives depression-like behavior in mice by inducing IL-17A production
Major depression disorder is a common illness that severely limits psychosocial functioning, affects outcomes of other diseases, and diminishes the quality of life. High-salt diet (HSD) has long been closely associated with the occurrence and development of depression, but whether or how HSD causes depression remains unclear. In this study, HSD induces depression-like behavior in… Continue reading High- #salt #diet drives depression-like behavior in mice by inducing IL-17A production
The Effect of 4:3 Intermittent #Fasting on #Weight Loss at 12 Months: A Randomized Clinical Trial
AbstractBackground:Long-term (≥12 months) randomized trials evaluating the efficacy of intermittent fasting (IMF) as a dietary weight loss strategy are limited. Furthermore, no studies have compared IMF versus daily caloric restriction (DCR) when both interventions are provided in the context of a guidelines-based behavioral weight loss program.Objective:To compare the effects of 4:3 IMF versus DCR on… Continue reading The Effect of 4:3 Intermittent #Fasting on #Weight Loss at 12 Months: A Randomized Clinical Trial
Atypical #gut microbial ecosystem from athletes with very high exercise capacity improves insulin sensitivity and muscle glycogen store in mice
Gut bacterial ecosystem is linked to host’s exercise capacity independent of food habits• Despite reduced bacterial diversity, endurance athletes exhibit higher fecal SCFA levels• Gut microbiota from athletes improves insulin sensitivity of transplanted mice• The gut bacterial ecosystem might be driven by access to energy resources left by the hostSummaryAlthough the gut microbiota is known… Continue reading Atypical #gut microbial ecosystem from athletes with very high exercise capacity improves insulin sensitivity and muscle glycogen store in mice
Optimal #dietary patterns for healthy #aging
As the global population ages, it is critical to identify diets that, beyond preventing noncommunicable diseases, optimally promote healthy aging. Here, using longitudinal questionnaire data from the Nurses’ Health Study (1986–2016) and the Health Professionals Follow-Up Study (1986–2016), we examined the association of long-term adherence to eight dietary patterns and ultraprocessed food consumption with healthy… Continue reading Optimal #dietary patterns for healthy #aging
Five-Year Changes in 24-Hour #Sleep-Wake Activity and #Dementia Risk in Oldest Old Women
AbstractBackground and ObjectivesSleep disruptions are associated with cognitive aging in older adults. However, little is known about longitudinal sleep changes in the oldest old and whether these changes are linked to cognitive impairment. We aimed to determine whether changes in 24-hour multidimensional sleep-wake activity are associated with mild cognitive impairment (MCI) and dementia in oldest… Continue reading Five-Year Changes in 24-Hour #Sleep-Wake Activity and #Dementia Risk in Oldest Old Women
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