Participants with hypertension but without diabetes (N = 1167) were randomized to an SBP target below 120 mm Hg (intensive treatment) vs a target below 140 mm Hg (standard treatment).. Intensive treatment led to significant reductions in cardiovascular events (hazard ratio [HR] = .66; 95% confidence interval [CI] = .49‐.90), mortality (HR = .67; 95% CI =… Continue reading Intensive vs Standard Blood #Pressure Control in Adults 80 Years or Older: A Secondary Analysis of the #Systolic Blood Pressure Intervention Trial
Electronic-#cigarette smoke induces #lung adenocarcinoma and #bladder urothelial hyperplasia in mice
Electronic-cigarettes (E-cigs) are marketed as a safe alternative to tobacco to deliver the stimulant nicotine, and their use is gaining in popularity, particularly among the younger population. We recently showed that mice exposed to short-term (12 wk) E-cig smoke (ECS) sustained extensive DNA damage in lungs, heart, and bladder mucosa and diminished DNA repair in… Continue reading Electronic-#cigarette smoke induces #lung adenocarcinoma and #bladder urothelial hyperplasia in mice
Assessing the Risk for #Gout With Sodium–Glucose Cotransporter-2 Inhibitors in Patients With Type 2 Diabetes: A Population-Based Cohort Study
Hyperuricemia is common in patients with type 2 diabetes mellitus and is known to cause gout. Sodium–glucose cotransporter-2 (#SGLT2) inhibitors prevent glucose reabsorption and lower serum uric acid levels.. ..The gout incidence rate was lower among patients prescribed an SGLT2 inhibitor (4.9 events per 1000 person-years) than those prescribed a GLP1 agonist (7.8 events per… Continue reading Assessing the Risk for #Gout With Sodium–Glucose Cotransporter-2 Inhibitors in Patients With Type 2 Diabetes: A Population-Based Cohort Study
#C-reactive protein mediates the association between leisure-time physical #activity and #lung function in middle-aged and older adults
Although previous studies have reported the benefits of physical activity (PA) to lung function in middle-aged and older adults, the biological mechanisms are still unclear.. ..Multiple linear regression models suggested that higher PA was associated with lower levels of CRP (β = − 0.048, P = 0.002 for moderate PA; β = − 0.108, P < 0.001 for high PA). CRP negatively correlated with FEV1… Continue reading #C-reactive protein mediates the association between leisure-time physical #activity and #lung function in middle-aged and older adults
Dietary #Potassium Intake Remains Low and #Sodium Intake Remains High, and Most Sodium is Derived from Home Food Preparation for Chinese Adults, 1991–2015 Trends
..Sodium intake decreased from 6.3 g/d in 1991 to 4.1 g/d in 2015, still twice the tolerable upper intake recommended by the WHO. Potassium intake was 1.7 g/d in 1991 and 1.5 g/d in 2015, below half that recommended by the WHO. The Na/K ratio decreased from 4.1 (ratios in g) in 1991 to 3.1… Continue reading Dietary #Potassium Intake Remains Low and #Sodium Intake Remains High, and Most Sodium is Derived from Home Food Preparation for Chinese Adults, 1991–2015 Trends
Decreasing human body #temperature in the United States since the industrial revolution
In 1851, the German In 1851, the German physician Carl Reinhold August Wunderlich obtained millions of axillary temperatures from 25,000 patients in Leipzig, thereby establishing the standard for normal human body temperature of 37°C or 98.6 °F (range: 36.2–37.5°C [97.2- 99.5 °F]) (Mackowiak, 1997; Wunderlich and Sequin, 1871). A compilation of 27 modern studies, however… Continue reading Decreasing human body #temperature in the United States since the industrial revolution
Prevalence and clinical implications of #sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study
Emerging evidence on body composition suggests that sarcopenic obesity (obesity with depleted muscle mass) might be predictive of morbidity and mortality in non-malignant disease and also of toxicity to chemotherapy.. ..Available lumbar CT images of the obese patients were analysed for total skeletal muscle cross-sectional area; these values were also used to estimate total body… Continue reading Prevalence and clinical implications of #sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study
The Risk of Head #Injuries Associated With Antipsychotic Use Among Persons With #Alzheimer’s disease
Antipsychotic use is associated with risk of falls among older persons, but we are not aware of previous studies investigating risk of head injuries. We studied the association of antipsychotic use and risk of head injuries among community dwellers with Alzheimer's disease (AD) ..Antipsychotic use was associated with an increased risk of head injuries (event… Continue reading The Risk of Head #Injuries Associated With Antipsychotic Use Among Persons With #Alzheimer’s disease
Adrenergic Signaling in #Muscularis Macrophages Limits Infection-Induced Neuronal Loss
..Enteric-associated neurons (EANs) are closely associated with immune cells and continuously monitor and modulate homeostatic intestinal functions, including motility and nutrient sensing. Bidirectional interactions between neuronal and immune cells are altered during disease processes such as neurodegeneration or #irritable bowel syndrome. We investigated the effects of infection-induced inflammation on intrinsic EANs (iEANs) and the role… Continue reading Adrenergic Signaling in #Muscularis Macrophages Limits Infection-Induced Neuronal Loss
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