Parkinson’s disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson’s disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a potential alternative is to replace lost neurons to reconstruct disrupted circuits2. Here we… Continue reading Reversing a model of #Parkinson’s disease with in situ converted nigral neurons
Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study
Increasing evidence supports reciprocal communication between the enteric and the central nervous system in disease, termed the ‘gut–brain axis’. Recent findings suggest a connection between IBD and development of Parkinson’s disease. The role of IBD in dementia, another insidious neurodegenerative disorder, has not been explored.. ..Overall incidence of dementia among patients with IBD was significantly… Continue reading Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study
Greater T Regulatory Cells in Females Attenuate DOCA-Salt–Induced Increases in Blood Pressure Versus Males
Hypertension is the most common risk factor for cardiovascular disease, causing over 18 million deaths a year. Although the mechanisms controlling blood pressure (BP) in either sex remain largely unknown, T cells play a critical role in the development of hypertension. Further evidence supports a role for the immune system in contributing to sex differences… Continue reading Greater T Regulatory Cells in Females Attenuate DOCA-Salt–Induced Increases in Blood Pressure Versus Males
Healthy #lifestyle and the risk of #Alzheimer dementia
Using data from the Chicago Health and Aging Project (CHAP; n = 1,845) and the Rush Memory and Aging Project (MAP; n = 920), we defined a healthy lifestyle score on the basis of nonsmoking, ≥150 min/wk moderate/vigorous-intensity physical activity, light to moderate alcohol consumption, high-quality Mediterranean-DASH Diet.. ..During a median follow-up of 5.8 years… Continue reading Healthy #lifestyle and the risk of #Alzheimer dementia
Left Atrial Appendage Closure Versus Direct Oral Anticoagulants in High-Risk Patients With Atrial Fibrillation
Percutaneous left atrial appendage closure (LAAC) is noninferior to vitamin K antagonists (VKAs) for preventing atrial fibrillation (AF)–related stroke. However, direct oral anticoagulants (DOACs) have an improved safety profile over VKAs, and their effect on cardiovascular and neurological outcomes relative to LAAC is unknown.. A high-risk patient cohort (CHA2DS2-VASc: 4.7 ± 1.5) was randomized to… Continue reading Left Atrial Appendage Closure Versus Direct Oral Anticoagulants in High-Risk Patients With Atrial Fibrillation
Detection of Ciprofloxacin resistant beta lactamase producing Neisseria meningitidis
What is already known about this topic? Most Neisseria meningitidis isolates in the United States have been susceptible to antibiotics recommended for treatment and prophylaxis. What is added by this report? During 2019–2020, 11 meningococcal isolates from U.S. patients had isolates containing a blaROB-1 β-lactamase gene associated with penicillin resistance and mutations associated with ciprofloxacin… Continue reading Detection of Ciprofloxacin resistant beta lactamase producing Neisseria meningitidis
Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma
Cavernous angiomas (CA) are common vascular anomalies causing brain hemorrhage. Based on mouse studies, roles of gram-negative bacteria and altered intestinal homeostasis have been implicated in CA pathogenesis, and pilot study had suggested potential microbiome differences between non-CA and CA individuals based on 16S rRNA gene sequencing. We here assess microbiome differences in a larger… Continue reading Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma
Frequent Coffee Consumption is Associated with Lower Incidence of Arrhythmias
..The study reviewed coffee intake information and relevant data for 296,227 participants in the UK Biobank. The mean age of participants was 56.69 ± 7.98 and 51.6 percent of participants were female. Investigators used multivariate Cox proportional hazards regression analysis to test the association between coffee consumption and arrhythmia risk and plotted a Kaplan- Meier… Continue reading Frequent Coffee Consumption is Associated with Lower Incidence of Arrhythmias
Sustained representation of perspectival shape
Our experience of the world goes beyond the light reaching our eyes: Even when a coin is tilted in depth, we infer the circular shape it truly has, rather than the ellipse it projects. But do we ever escape the perspective from which we view the world? A centuries-old philosophical debate asks whether objects of… Continue reading Sustained representation of perspectival shape
