Ankle‐brachial index (ABI) is used to identify lower‐extremity peripheral artery disease (PAD). However, its association with severe ischemic leg outcomes (eg, amputation) has not been investigated in the general population. Methods and ResultsAmong 13 735 ARIC (Atherosclerosis Risk in Communities) study participants without clinical manifestations of PAD (mean age, 54 [SD, 5.8] years; 44.4% men;… Continue reading Ankle‐Brachial Index and Subsequent Risk of Severe #Ischemic #Leg Outcomes: The ARIC Study
The spike protein of #SARS-CoV-2 variant A.30 is heavily #mutated and evades vaccine-induced antibodies with high efficiency
The COVID-19 pandemic, caused by SARS-CoV-2, continues to rage in many countries, straining health systems and economies. Vaccines protect against severe disease and death and are considered central to ending the pandemic. COVID-19 vaccines (and SARS-CoV-2 infection) elicit antibodies that are directed against the viral spike (S) protein and neutralize the virus. However, the emergence… Continue reading The spike protein of #SARS-CoV-2 variant A.30 is heavily #mutated and evades vaccine-induced antibodies with high efficiency
Epidemiology of type 2 #diabetes remission in Scotland in 2019: A cross-sectional population-based study
Clinical pathways are changing to incorporate support and appropriate follow-up for people to achieve remission of type 2 diabetes, but there is limited understanding of the prevalence of remission in current practice or patient characteristics associated with remission. Methods and findingsWe carried out a cross-sectional study estimating the prevalence of remission of type 2 diabetes… Continue reading Epidemiology of type 2 #diabetes remission in Scotland in 2019: A cross-sectional population-based study
Estimating dose-response relationships for vitamin #D with #coronary heart disease, #stroke, and all-cause mortality: observational and Mendelian randomisation analyses
SummaryBackgroundRandomised trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalisability of results to individuals with low vitamin D status is unclear. We aimed to characterise dose-response relationships between 25-hydroxyvitamin D (25[OH]D) concentrations and risk of coronary heart disease, stroke, and all-cause mortality in observational and Mendelian… Continue reading Estimating dose-response relationships for vitamin #D with #coronary heart disease, #stroke, and all-cause mortality: observational and Mendelian randomisation analyses
Comprehensive investigations revealed consistent pathophysiological alterations after #vaccination with #COVID-19 vaccines
Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in… Continue reading Comprehensive investigations revealed consistent pathophysiological alterations after #vaccination with #COVID-19 vaccines
SARS–CoV–2 #Spike Impairs #DNA Damage Repair and InhibitsV(D)J Recombination In Vitro
Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy.Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly in-fluences the clinical outcomes of patients. Clinical studies have indicated that patients with severeCOVID–19 exhibit delayed and weak adaptive… Continue reading SARS–CoV–2 #Spike Impairs #DNA Damage Repair and InhibitsV(D)J Recombination In Vitro
#Zinc for the prevention or treatment of acute viral #respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials
To evaluate the benefits and risks of zinc formulations compared with controls for prevention or treatment of acute viral respiratory tract infections (RTIs) in adults. Method Seventeen English and Chinese databases were searched in April/May 2020 for randomised controlled trials (RCTs), and from April/May 2020 to August 2020 for SARS-CoV-2 RCTs. Cochrane rapid review methods… Continue reading #Zinc for the prevention or treatment of acute viral #respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials
Functional genomics and metabolomics advance the ethnobotany of the #Samoan traditional medicine “matalafi”
Medicinal plants with extensive ethnobotanical histories, particularly those from Asia, have contributed to the approval of natural compounds as pharmaceutical drugs. In contrast, Samoan traditional medicine is relatively understudied. Working with traditional healers via an ethical, data sovereignty–driven collaboration led by indigenous Samoan researchers, we elucidate the chemical biology of the poorly understood but often-used… Continue reading Functional genomics and metabolomics advance the ethnobotany of the #Samoan traditional medicine “matalafi”
Association Between Genetic Risk for #Psychiatric Disorders and the Probability of Living in #Urban Settings
Urban residence has been highlighted as an environmental risk factor for schizophrenia and, to a lesser extent, several other psychiatric disorders. However, few studies have explored genetic effects on the choice of residence. Objective To investigate whether individuals with genetic predisposition to a range of psychiatric disorders have an increased likelihood to live in urban… Continue reading Association Between Genetic Risk for #Psychiatric Disorders and the Probability of Living in #Urban Settings
2 Medical News 