We propose the savanna theory of happiness, which suggests that it is not only the current consequences of a given situation but also its ancestral consequences that affect individuals’ life satisfaction and explains why such influences of ancestral consequences might interact with intelligence. We choose two varied factors that characterize basic differences between ancestral and… Continue reading Country roads, take me home… to my friends: How #intelligence, population density, and friendship affect modern #happiness
Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function
To investigate whether osteoarthritis (OA)–specific assessment values (i.e. Western Ontario and McMaster University Osteoarthritis Index [WOMAC]) and generic pain and function (visual analog scale [VAS], Hanover Functionality Status Questionnaire [FFbH]) measured before and 12 months after arthroplasty are associated with the risk of long-term mortality in a cohort of patients with advanced OA of the… Continue reading Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function
Disruption of autophagy by increased #5-HT alters gut microbiota and enhances susceptibility to experimental colitis and #Crohn’s disease
Autophagy, an essential intracellular recycling process, is linked to the pathogenesis of various diseases including Crohn’s disease (CD). Factors that lead to the development of impaired autophagy during intestinal inflammation remain largely unexplored. Here, we report the impact of the interaction between serotonin [5-hydroxytryptamine;(5-HT)] and autophagy in colitis in mouse and human studies. In mice,… Continue reading Disruption of autophagy by increased #5-HT alters gut microbiota and enhances susceptibility to experimental colitis and #Crohn’s disease
Genome-wide analysis of 53,400 people with #irritable bowel syndrome highlights shared genetic pathways with #mood and #anxiety disorders
Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe… Continue reading Genome-wide analysis of 53,400 people with #irritable bowel syndrome highlights shared genetic pathways with #mood and #anxiety disorders
Discovery of Autoantibodies Targeting #Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology
Failure of the glomerular filtration barrier, primarily by loss of slit diaphragm architecture, underlies nephrotic syndrome in minimal change disease. The etiology remains unknown. The efficacy of B cell-targeted therapies in some patients, together with the known proteinuric effect of antinephrin antibodies in rodent models, prompted us to hypothesize that nephrin autoantibodies may be present… Continue reading Discovery of Autoantibodies Targeting #Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology
EDP-305 in patients with #NASH: A phase II double-blind placebo-controlled dose-ranging study
•EDP-305 is an oral farnesoid X receptor (FXR) agonist being developed to treat nonalcoholic steatohepatitis (NASH).•In a randomized, placebo-controlled study, 12-week study, EDP-305 reduced ALT levels and MRI-PDFF•These results support further development of EDP-305 in patients with NASH with longer term studies. ABSTRACTBackground & AimsEDP-305 is an oral farnesoid X receptor (FXR) agonist under development… Continue reading EDP-305 in patients with #NASH: A phase II double-blind placebo-controlled dose-ranging study
A class II MHC-targeted vaccine elicits immunity against #SARS-CoV-2 and its variants
Vaccines remain the best hope of curtailing SARS-CoV-2 transmission, morbidity, and mortality. Currently available vaccines require cold storage and sophisticated manufacturing capacity, complicating their distribution, especially in less developed countries. We report a protein-based SARS-CoV-2 vaccine that directly and specifically targets antigen-presenting cells. It consists of the SARS-CoV-2 Spike receptor-binding domain (SpikeRBD) fused to a… Continue reading A class II MHC-targeted vaccine elicits immunity against #SARS-CoV-2 and its variants
Association Between #Melanoma Detected During Routine Skin Checks and Mortality
Are melanomas diagnosed through routine skin checks (a proxy for skin cancer screening) associated with reduced melanoma-specific and all-cause mortality? Findings This population-based cohort study included 2452 patients, each with 1 diagnosed melanoma, 35% of which were detected during a routine skin check. In multivariable analyses, routine skin-check detection was associated with a subhazard ratio… Continue reading Association Between #Melanoma Detected During Routine Skin Checks and Mortality
Strategies to Optimize #Nephrolithiasis Emergency Care (STONE): Prospective Evaluation of an Emergency Department Clinical Pathway
To convene a multi-disciplinary panel to develop a pathway for Emergency Department (ED) patients with suspected nephrolithiasis and then prospectively evaluate its effect on patient care. Materials and MethodsThe STONE Pathway was developed and linked to order sets within our Electronic Health Record in April 2019. Records were prospectively reviewed for ED patients who underwent… Continue reading Strategies to Optimize #Nephrolithiasis Emergency Care (STONE): Prospective Evaluation of an Emergency Department Clinical Pathway
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