Importance Moderate to vigorous–intensity physical activity (MVPA) is essential for primary and secondary prevention of cardiovascular disease (CVD), but long-term patterns around CVD events remain underexplored.Objective To evaluate MVPA trajectories across adulthood, pre-CVD and post-CVD changes, and demographic variations.Design, Setting, and Participants Data were drawn from CARDIA (Coronary Artery Risk Development in Young Adults), a… Continue reading Trajectories of #Physical Activity Before and After #Cardiovascular Disease Events in CARDIA Participants
#Electrophysiological correlates of dynamic #cycling in #Parkinson’s diseaseAuthor
Physical exercise like dynamic cycling has shown promise in enhancing motor function in Parkinson’s disease (PD). We examined the underlying mechanisms of dynamic cycling in PD, emphasizing its impact on the activity of the subthalamic nucleus (STN), a pivotal region within the basal ganglia.MethodsThe investigation involved 100 dynamic cycling sessions conducted among nine PD individuals.… Continue reading #Electrophysiological correlates of dynamic #cycling in #Parkinson’s diseaseAuthor
Global Estimates of #Lives and Life-Years Saved by #COVID-19 #Vaccination During 2020-2024
Importance Estimating global lives and life-years saved is important to put into perspective the benefits of COVID-19 vaccination. Prior studies have focused mainly on the pre-Omicron period or only on specific regions, and lack crucial life-year calculations and often depend on strong modeling assumptions with unaccounted uncertainty.Objective To calculate the lives and life-years saved by… Continue reading Global Estimates of #Lives and Life-Years Saved by #COVID-19 #Vaccination During 2020-2024
#PREVENT Risk Age Equations and Population Distribution in US #Adults
Current US guidelines recommend absolute risk estimation of cardiovascular disease (CVD) to guide decisions on preventive therapies, but communicating absolute risk alone can be challenging for patients and clinicians.1 In 2021, the European Society of Cardiology guidelines added a recommendation to calculate risk age along with absolute risk to improve communication.2 Risk age represents the… Continue reading #PREVENT Risk Age Equations and Population Distribution in US #Adults
Total and specific #potato intake and risk of type 2 #diabetes: results from three US cohort studies and a substitution meta-analysis of prospective cohorts
Objectives To investigate the associations between total and individual potato intake and risk of type 2 diabetes (T2D), estimate the effect on T2D risk of replacing potatoes with whole grains and other major carbohydrate sources, and conduct a dose-response and substitution meta-analysis of prospective cohort studies.Design Prospective cohort study and dose-response meta-analysis of prospective cohort… Continue reading Total and specific #potato intake and risk of type 2 #diabetes: results from three US cohort studies and a substitution meta-analysis of prospective cohorts
#Dietary patterns and accelerated multimorbidity in #older adults
Diet could influence disease development and shape multimorbidity trajectories. Here we examined how four dietary patterns relate to 15-year multimorbidity accumulation in 2,473 community-dwelling older adults from the Swedish SNAC-K cohort. Multimorbidity was operationalized as the total number of chronic conditions and grouped into three organ systems. Higher adherence to the Mediterranean-DASH Diet Intervention for… Continue reading #Dietary patterns and accelerated multimorbidity in #older adults
Phenome-wide Analysis of #Diseases in Relation to Objectively Measured #Sleep Traits and Comparison with Subjective Sleep Traits in 88,461 Adults
Background: Sleep traits have been suggested to correlate with various diseases, but most evidence is based on subjective sleep measurement. We investigated the associations of accelerometer-derived objective sleep traits with diseases throughout physiological systems to ascertain whether the disease spectrum related to objective sleep traits differs from that related to subjective sleep traits. Methods: In… Continue reading Phenome-wide Analysis of #Diseases in Relation to Objectively Measured #Sleep Traits and Comparison with Subjective Sleep Traits in 88,461 Adults
#Sucralose consumption ablates #cancer immunotherapy response through #microbiome disruption
Gut microbiota composition is directly associated with response to immunotherapies in cancer. How the diet impacts the gut microbiota and downstream immune responses to cancer remains unclear. Here, we show that consumption of a common non-nutritive sweetener, sucralose, modifies microbiome composition, restricts T cell metabolism and function, and limits immunotherapy response in preclinical models of… Continue reading #Sucralose consumption ablates #cancer immunotherapy response through #microbiome disruption
#Thermal and Perceptual Responses of #Older Adults With #Fan Use in #Heat ExtremesA Secondary Analysis of a Randomized Clinical Trial
The US Centers for Disease Control and Prevention (CDC) advise against fan use above 32 °C (ie, 90 °F) because it can increase body temperature.1 Modeling suggests fans reduce body temperature up to 37 to 39 °C (ie, 99 to 102 °F), depending upon humidity.2 In humid heat, fan use reduced body temperature in young… Continue reading #Thermal and Perceptual Responses of #Older Adults With #Fan Use in #Heat ExtremesA Secondary Analysis of a Randomized Clinical Trial
2 Medical News 