As a result of the emergence and circulation of antigenically distinct SARS-CoV-2 variants, a number of variant-modified COVID-19 vaccines have been developed. Here we perform a meta-analysis of the available data on neutralisation titres from clinical studies comparing booster vaccination with either the current ancestral-based vaccines or variant-modified vaccines. We then use this to predict… Continue reading Predicting the efficacy of variant-modified COVID-19 vaccine boosters
Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
BackgroundStatin therapy is effective for the prevention of atherosclerotic cardiovascular disease and is widely prescribed, but there are persisting concerns that statin therapy might frequently cause muscle pain or weakness. We aimed to address these through an individual participant data meta-analysis of all recorded adverse muscle events in large, long-term, randomised, double-blind trials of statin… Continue reading Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Persistent varicella zoster virus infection following mRNA COVID-19 vaccination was associated with the presence of encoded spike protein in the lesion
BackgroundSince the campaign of vaccination against COVID-19 was started, a wide variety of cutaneous adverse effects after vaccination has been documented worldwide. Varicella zoster virus (VZV) reactivation was reportedly the most frequent cutaneous reaction in men after administration of mRNA COVID-19 vaccines, especially BNT162b2.AimsA patient, who had persistent skin lesions after BNT162b2 vaccination for such… Continue reading Persistent varicella zoster virus infection following mRNA COVID-19 vaccination was associated with the presence of encoded spike protein in the lesion
Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma
Activating KRAS mutations and functional loss of members of the SWI/SNF complex, including ARID1A, are found together in the primary liver tumor cholangiocarcinoma (CC). How these mutations cooperate to promote CC has not been established. Using murine models of hepatocyte and biliary-specific lineage tracing, we show that Kras and Arid1a mutations drive the formation of CC and tumor precursors from the biliary compartment,… Continue reading Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma
Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke
Background and Objectives: Current genome-wide association studies of ischemic stroke have focused primarily on late onset disease. As a complement to these studies, we sought to identifythe contribution of common genetic variants to risk of early onset ischemic stroke.Methods: We performed a meta-analysis of genome-wide association studies of early onset stroke (EOS), ages 18-59, using individual level… Continue reading Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke
Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants
To quantify the association of combined sleep behaviours and genetic susceptibility with the incidence of cardiovascular disease (CVD).Methods and resultsThis study included 385 292 participants initially free of CVD from UK Biobank. We newly created a healthy sleep score according to five sleep factors and defined the low-risk groups as follows: early chronotype, sleep 7–8 h per… Continue reading Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants
A thermometer circuit for hot temperature adjusts Drosophila behavior to persistent heat
Small poikilotherms such as the fruit fly Drosophila depend on absolute temperature measurements to identify external conditions that are above (hot) or below (cold) their preferred range and to react accordingly. Hot and cold temperatures have a different impact on fly activity and sleep, but the circuits and mechanisms that adjust behavior to specific thermal conditions are… Continue reading A thermometer circuit for hot temperature adjusts Drosophila behavior to persistent heat
Single-Channel EEG Features Reveal an Association With Cognitive Decline in Seniors Performing Auditory Cognitive Assessment
Background: Cognitive decline remains highly underdiagnosed despite efforts to find novel cognitive biomarkers. Electroencephalography (EEG) features based on machine-learning (ML) may offer a non-invasive, low-cost approach for identifying cognitive decline. However, most studies use cumbersome multi-electrode systems. This study aims to evaluate the ability to assess cognitive states using machine learning (ML)-based EEG features extracted from… Continue reading Single-Channel EEG Features Reveal an Association With Cognitive Decline in Seniors Performing Auditory Cognitive Assessment
Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank
Tea is frequently consumed worldwide, but the association of tea drinking with mortality risk remains inconclusive in populations where black tea is the main type consumed.Objective:To evaluate the associations of tea consumption with all-cause and cause-specific mortality and potential effect modification by genetic variation in caffeine metabolism.Design:Prospective cohort study.Setting:The UK Biobank.Participants:498 043 men and women aged… Continue reading Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank
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