Chlamydia pneumoniae is a respiratory tract pathogen but can also infect the central nervous system (CNS). Recently, the link between C. pneumoniae CNS infection and late-onset dementia has become increasingly evident. In mice, CNS infection has been shown to occur weeks to months after intranasal inoculation. By isolating live C. pneumoniae from tissues and using immunohistochemistry, we show that C. pneumoniae can… Continue reading Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk
Timing of physical activity in relation to liver fat content and insulin resistance
Aims/hypothesisWe hypothesised that the insulin-sensitising effect of physical activity depends on the timing of the activity. Here, we examined cross-sectional associations of breaks in sedentary time and timing of physical activity with liver fat content and insulin resistance in a Dutch cohort.MethodsIn 775 participants of the Netherlands Epidemiology of Obesity (NEO) study, we assessed sedentary… Continue reading Timing of physical activity in relation to liver fat content and insulin resistance
Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients With Celiac Disease Exposed to a Gluten Challenge
AbstractBackground and aims: Gluten ingestion in patients with celiac disease can lead to gastrointestinal symptoms and small intestinal mucosal injury.Methods: This gluten challenge phase 2 trial was double blind and placebo controlled, and it assessed the efficacy and safety of a 1200-mg dose of IMGX003 in patients with celiac disease exposed to 2 g of gluten per… Continue reading Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients With Celiac Disease Exposed to a Gluten Challenge
Effects of a Low-Carbohydrate Dietary Intervention on Hemoglobin A1cA Randomized Clinical Trial
Importance Low-carbohydrate diets decrease hemoglobin A1c (HbA1c) among patients with type 2 diabetes at least as much as low-fat diets. However, evidence on the effects of low-carbohydrate diets on HbA1c among individuals with HbA1c in the range of prediabetes to diabetes not treated by diabetes medications is limited.Objective To study the effect of a behavioral intervention promoting a low-carbohydrate diet… Continue reading Effects of a Low-Carbohydrate Dietary Intervention on Hemoglobin A1cA Randomized Clinical Trial
Association Between Smoking, Smoking Cessation, and Mortality by Race, Ethnicity, and Sex Among US Adults
Key PointsQuestion What are the contemporary hazards of cigarette smoking and benefits of quitting smoking by race, ethnicity, and sex among US adults?Findings In this prospective cohort study of 551 388 US adults, smoking was associated with appreciably greater all-cause mortality compared with never smoking irrespective of race, ethnicity, or sex. Quitting smoking was associated with a reduction… Continue reading Association Between Smoking, Smoking Cessation, and Mortality by Race, Ethnicity, and Sex Among US Adults
Internal medicine physician embedded in an orthopedic service in a level 1 hospital: clinical impact
AbstractBackground: The aim of our study was to evaluate the impact of an internist physician specialized in diabetes, appointed as an in-house physician in the orthopedic wards, on improving clinical outcomes and in particular 30-day mortality. Methods: We analyzed a cohort of patients hospitalized more than 24 h in the orthopedic service. The analyses included a comparative… Continue reading Internal medicine physician embedded in an orthopedic service in a level 1 hospital: clinical impact
Trends in US Emergency Department Use After Sexual Assault, 2006-2019
Importance Adult sexual assault (SA) survivors experience numerous emergent health problems, yet few seek emergency medical care. Quantifying the number and types of survivors presenting to US emergency departments (EDs) after SA can inform health care delivery strategies to reduce survivor morbidity and mortality. Objective To quantify ED use and factors that influenced seeking ED care for… Continue reading Trends in US Emergency Department Use After Sexual Assault, 2006-2019
Association between hypercholesterolemia and mortality risk among patients referred for cardiac imaging test: Evidence of a “cholesterol paradox?”
Aim: Some observational studies have observed a lower, rather than higher, mortality rate in association with hypercholesterolemia during follow-up of patients after cardiac stress testing. We aim to assess the relationship of hypercholesterolemia and other CAD risk factors to mortality across a wide spectrum of patients referred for various cardiac tests.Methods and results: We identified four cardiac… Continue reading Association between hypercholesterolemia and mortality risk among patients referred for cardiac imaging test: Evidence of a “cholesterol paradox?”
SARS-CoV-2—The Role of Natural Immunity: A Narrative Review
Background: Both natural immunity and vaccine-induced immunity to COVID-19 may be useful to reduce the mortality/morbidity of this disease, but still a lot of controversy exists. Aims: This narrative review analyzes the literature regarding these two immunitary processes and more specifically: (a) the duration of natural immunity; (b) cellular immunity; (c) cross-reactivity; (d) the duration… Continue reading SARS-CoV-2—The Role of Natural Immunity: A Narrative Review
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