BACKGROUNDTo investigate the associations between courses of depression, the application of depression treatment, and the risk of incident dementia.METHODSIn this prospective cohort study, 354,313 participants aged 50 to 70 years were recruited from the UK Biobank between 2006 and 2010, and were followed-up until 2020, with a total of 4,212,929 person-years. We initially studied the… Continue reading Depression, Depression Treatments, and Risk of Incident Dementia: A Prospective Cohort Study of 354,313 Participants
Zinc ions prevent α-synuclein aggregation by enhancing chaperone function of human serum albumin
Metal ions present in cellular microenvironment have been implicated as drivers of aggregation of amyloid forming proteins. Zinc (Zn2+) ions have been reported to directly interact with α-synuclein (AS), a causative agent of Parkinson's disease and other neurodegenerative diseases, and promote its aggregation. AS is a small intrinsically disordered protein (IDP) i.e., understanding molecular factors… Continue reading Zinc ions prevent α-synuclein aggregation by enhancing chaperone function of human serum albumin
The Cost of Inaction on Physical Inactivity to Healthcare Systems
Background: Physical inactivity (PI) is an important modifiable risk factor for noncommunicable diseases (NCDs) and mental health conditions. Estimating the public healthcare costs associated with these diseases due to PI will help policymakers to prioritise investment in policy actions to promote and enable more people to be more active.Methods: We used a population attributable fraction… Continue reading The Cost of Inaction on Physical Inactivity to Healthcare Systems
Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey
AbstractObjectiveThe purpose of this study was to identify the prevalence of severe headache or migraine and the association between dietary thiamine and riboflavin intake with headache history using a large, nationally representative population sample.BackgroundSevere headache and migraine are common and disabling neurological disorders worldwide. Previous studies revealed that the B vitamin group, as an important… Continue reading Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey
Role of housing in blood pressure control: a review of evidence from the Smart Wellness Housing survey in Japan
Current countermeasures for preventing hypertension emphasize only improvements to lifestyle. Recently, improving life environment has attracted attention, in parallel with publication of the WHO Housing and health guidelines. We quantitatively evaluated the relationship between housing thermal environment and blood pressure (BP) in a real-world setting. We conducted a nationwide, prospective intervention study—the Smart Wellness Housing… Continue reading Role of housing in blood pressure control: a review of evidence from the Smart Wellness Housing survey in Japan
Identifying Dynamic Patterns of Polypharmacy for Patients with Dementia from Primary Care Electronic Health Records: A Machine Learning Driven Longitudinal Study
is unclear how medication use evolved before diagnosis of dementia (DoD). This study aims to identify varied patterns of polypharmacy before DoD, their prevalence and possible complications. We collected primary care e-health records for 33,451 dementia patients in Wales from 1990 to 2015. The medication uses in every 5-year period along with 20-years prior to… Continue reading Identifying Dynamic Patterns of Polypharmacy for Patients with Dementia from Primary Care Electronic Health Records: A Machine Learning Driven Longitudinal Study
Older adults with lower working memory capacity benefit from transcranial direct current stimulation when combined with working memory training: A preliminary study
Aging is a very diverse process: successful agers retain most cognitive functioning, while others experience mild to severe cognitive decline. This decline may eventually negatively impact one’s everyday activities. Therefore, scientists must develop approaches to counteract or, at least, slow down the negative change in cognitive performance of aging individuals. Combining cognitive training and transcranial… Continue reading Older adults with lower working memory capacity benefit from transcranial direct current stimulation when combined with working memory training: A preliminary study
The unlikelihood effect: When knowing more creates the perception of less.
People face increasingly detailed information related to a range of risky decisions. To aid individuals in thinking through such risks, various forms of policy and health messaging often enumerate their causes. Whereas some prior literature suggests that adding information about causes of an outcome increases its perceived likelihood, we identify a novel mechanism through which… Continue reading The unlikelihood effect: When knowing more creates the perception of less.
RORβ modulates a gene program that is protective against articular cartilage damage
Osteoarthritis (OA) is the most prevalent chronic joint disease which increases in frequency with age eventually impacting most people over the age of 65. OA is the leading cause of disability and impaired mobility, yet the pathogenesis of OA remains unclear. Treatments have focused mainly on pain relief and reducing joint swelling. Currently there are… Continue reading RORβ modulates a gene program that is protective against articular cartilage damage
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