Many adults become vitamin D deficient or insufficient during winter at northerly latitudes when cutaneous vitamin D synthesis does not occur. Vitamin D accumulates in adipose tissue and people with overweight or obesity are more likely to have low systemic vitamin D. This randomized controlled trial demonstrates that regular exercise completely maintains serum concentrations of… Continue reading #Exercise without Weight Loss Prevents Seasonal Decline in Vitamin #D Metabolites: The VitaDEx Randomized Controlled Trial
Category: supplements
The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Introduction: Vaccine-related myocarditis is recognized as a rare but important complication, especially after mass-scale mRNA COVID-19 vaccination. Knowledge regarding how to minimize the risk is limited. As NK cells can mediate acute myocarditis after mRNA COVID-19 vaccination and vitamin D may inhibit NK cells via cytokine modulation, we hypothesize that the myocarditis side effect is… Continue reading The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
#Sweetener #aspartame aggravates #atherosclerosis through insulin-triggered inflammation
Highlights•Aspartame increases insulin levels through parasympathetic activation•An insulin-dependent mechanism of the aspartame-aggravated atherosclerosis•The CX3CL1-CX3CR1 signaling mediates insulin-induced endothelial inflammation•A CX3CL1-CX3CR1-dependent mechanism of aspartame-exacerbated atherosclerosis SummaryConsumption of artificial sweeteners (ASWs) in various foods and beverages has been linked to an increased risk of cardiovascular diseases (CVDs). However, molecular mechanisms underlying ASW-associated CVD remain unknown. Here, we… Continue reading #Sweetener #aspartame aggravates #atherosclerosis through insulin-triggered inflammation
Salt Substitution and Recurrent #Stroke and DeathA Randomized Clinical Trial
Question Does the use of a reduced-sodium, added-potassium salt substitute vs regular salt decrease the risk of stroke recurrence and death in patients with a history of stroke?Findings In this prespecified subgroup analysis of the Salt Substitute and Stroke Study (SSaSS) trial involving 15 249 patients with stroke, the use of a salt substitute led… Continue reading Salt Substitution and Recurrent #Stroke and DeathA Randomized Clinical Trial
Individual and additive effects of vitamin #D, #omega-3 and #exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the results of a post hoc analysis among 777 participants of the DO-HEALTH trial on the effect of vitamin D (2,000 IU per… Continue reading Individual and additive effects of vitamin #D, #omega-3 and #exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
Dietary #fructose enhances #tumour growth indirectly via interorgan lipid transfer
Fructose consumption has increased considerably over the past five decades, largely due to the widespread use of high-fructose corn syrup as a sweetener1. It has been proposed that fructose promotes the growth of some tumours directly by serving as a fuel2,3. Here we show that fructose supplementation enhances tumour growth in animal models of melanoma,… Continue reading Dietary #fructose enhances #tumour growth indirectly via interorgan lipid transfer
Blood #Pressure Decreases in #Overweight Elderly Individuals on Vitamin #D: A Randomized Trial
AbstractContextEvidence for a beneficial role of vitamin D on blood pressure (BP) outcomes is inconclusive.ObjectiveThis work aimed to investigate the effect of 2 doses of cholecalciferol (vitamin D3) supplementation coadministered with calcium on systolic blood pressure (SBP) and diastolic blood pressure (DBP).MethodsExploratory analyses were conducted from a 1-year, multicenter, double-blind, randomized controlled trial (RCT). Total… Continue reading Blood #Pressure Decreases in #Overweight Elderly Individuals on Vitamin #D: A Randomized Trial
Associations of plasma omega-6 and omega-3 #fatty acids with overall and 19 site-specific #cancers: A population-based cohort study in UK Biobank
AbstractPrevious epidemiological studies on the associations between polyunsaturated fatty acids (PUFAs) and cancer incidence have been inconsistent. We investigated the associations of plasma omega-3 and omega-6 PUFAs with the incidence of overall and 19 site-specific cancers in a large prospective cohort. 253,138 eligible UK Biobank participants were included in our study. With a mean follow-up… Continue reading Associations of plasma omega-6 and omega-3 #fatty acids with overall and 19 site-specific #cancers: A population-based cohort study in UK Biobank
Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin #D signaling
Central tolerance of thymocytes to self-antigen depends on the medullary thymic epithelial cell (mTEC) transcription factor autoimmune regulator (Aire), which drives tissue-restricted antigen (TRA) gene expression. Vitamin D signaling regulates Aire and TRA expression in mTECs, providing a basis for links between vitamin D deficiency and autoimmunity. We find that mice lacking Cyp27b1, which cannot… Continue reading Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin #D signaling
