Dear Editor,We read the article by Badier et al. entitled “IgA vasculitis in adult patients following vaccination by ChadOx1 nCoV-19”, published in Autoimmunity Reviews with interest. (1) We share the author's view that the COVID-19 vaccine could be the trigger of IgA vasculitis in the reported case. At our secondary/tertiary rheumatology centre, we have been… Continue reading Immune mediated events timely associated with COVID-19 vaccine. A comment on article by Badier, et al.: “IgA vasculitis in adult patients following vaccination by ChadOx1 nCoV-19”
Category: Rheumatology
#Intestinal barrier dysfunction plays an integral role in #arthritis pathology and can be targeted to ameliorate disease
HighlightsSerum gut-permeability markers LPB, LPS, and I-FABP are increased in RAMice with arthritis have increased gut permeability and intestinal inflammationBoth bacteria and leukocytes are needed to disrupt gut-barrier integrityPrevention of gut-barrier dysfunction in arthritis ameliorates joint inflammation Context and significanceRheumatoid arthritis is an autoimmune disorder characterized by chronic joint inflammation. Accumulating evidence suggests that changes… Continue reading #Intestinal barrier dysfunction plays an integral role in #arthritis pathology and can be targeted to ameliorate disease
#Hydroxychloroquine and Mortality Among Patients With Systemic #Lupus Erythematosus in the General Population
Hydroxychloroquine (HCQ) has been associated with improved survival among patients with systemic lupus erythematosus (SLE) from tertiary referral centers. We aimed to determine the potential impact of HCQ use on the risk of mortality among SLE patients in the general population. MethodsWe conducted a nested case–control study within an incident SLE cohort from the entire… Continue reading #Hydroxychloroquine and Mortality Among Patients With Systemic #Lupus Erythematosus in the General Population
Auto-immune #hepatitis following #COVID vaccination
Unprecedented loss of life due to the COVID pandemic has necessitated the development of several vaccines in record time. Most of these vaccines have received approval without being extensively whetted for their adverse effect and efficacy profiles. Most adverse effects have been mild, nonetheless, more serious thromboembolic events have also been reported. Autoimmune hepatitis (AIH)… Continue reading Auto-immune #hepatitis following #COVID vaccination
Prevalence of Nonradiographic #Sacroiliitis in Patients With Psoriatic #Arthritis: A Real-life Observational Study
To establish the prevalence of nonradiographic sacroiliitis within a real-life sample of patients with psoriatic arthritis (PsA), using pelvic radiographs and magnetic resonance imaging (MRI) of sacroiliac joints (SIJs). Methods. This cross-sectional study included 107 consecutive adults with PsA (Classification Criteria for Psoriatic Arthritis criteria). Participants completed clinical and laboratory evaluation, pelvic radiographs scored for… Continue reading Prevalence of Nonradiographic #Sacroiliitis in Patients With Psoriatic #Arthritis: A Real-life Observational Study
OP0012 ASSOCIATION BETWEEN PASSIVE #SMOKING IN CHILDHOOD AND ADULTHOOD, AND #RHEUMATOID ARTHRITIS: RESULTS FROM THE FRENCH E3N-EPIC COHORT STUDY
Rheumatoid arthritis (RA) is a systemic autoimmune disease of multifactorial aetiology, which preferentially affects women. To date, active smoking has been the most reproducibly reported risk factor for anti-citrullinated protein antibodies (ACPA) positive RA, particularly persons who carry the HLA-DRB1-shared epitope (SE) alleles. Objectives: We aimed to investigate the relationships between passive smoking in childhood… Continue reading OP0012 ASSOCIATION BETWEEN PASSIVE #SMOKING IN CHILDHOOD AND ADULTHOOD, AND #RHEUMATOID ARTHRITIS: RESULTS FROM THE FRENCH E3N-EPIC COHORT STUDY
Depleting #plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous #lupus
Plasmacytoid dendritic cells (pDCs) not only are specialized in their capacity to secrete large amounts of type I interferon (IFN) but also serve to enable both innate and adaptive immune responses through expression of additional proinflammatory cytokines, chemokines, and costimulatory molecules. Persistent activation of pDCs has been demonstrated in a number of autoimmune diseases. To… Continue reading Depleting #plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous #lupus
#Anticardiolipin and other #antiphospholipid antibodies in critically ill #COVID-19 positive and negative patients
Reports of severe COVID-19 being associated with thrombosis, antiphospholipid antibodies (APLA), and antiphospholipid syndrome have yielded disparate conclusions. Studies comparing patients with COVID-19 with contemporaneous controls of similar severity are lacking. Methods 22 COVID-19+ and 20 COVID-19– patients with respiratory failure admitted to intensive care were studied longitudinally. Demographic and clinical data were obtained from… Continue reading #Anticardiolipin and other #antiphospholipid antibodies in critically ill #COVID-19 positive and negative patients
#Cotrimoxazole prophylaxis prevents major infective episodes in patients with systemic #lupus erythematosus on immunosuppressants: A non-concurrent cohort study
Prophylactic trimethoprim-sulfamethoxazole (TMP-SMX) prevents pneumocystis jirovecii infection in SLE on immunosuppression. Its role in preventing other major infections in immuno suppressed SLE patients is unknown. Methods A non-concurrent cohort study was conducted on patients of SLE fulfilling SLICC and/or ACR 1997 criteria, who received tapering dose of steroid starting with ≥0.5 mg/kg/day of prednisolone or equivalent… Continue reading #Cotrimoxazole prophylaxis prevents major infective episodes in patients with systemic #lupus erythematosus on immunosuppressants: A non-concurrent cohort study
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