Central tolerance of thymocytes to self-antigen depends on the medullary thymic epithelial cell (mTEC) transcription factor autoimmune regulator (Aire), which drives tissue-restricted antigen (TRA) gene expression. Vitamin D signaling regulates Aire and TRA expression in mTECs, providing a basis for links between vitamin D deficiency and autoimmunity. We find that mice lacking Cyp27b1, which cannot… Continue reading Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin #D signaling
Category: Rheumatology
#Caffeine improves systemic #lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival
We studied the role of caffeine intake on endothelial function in SLE by assessing its effect on circulating endothelial progenitor cells (EPCs) both ex vivo in SLE patients and in vitro in healthy donors (HD) treated with SLE sera.MethodsWe enrolled SLE patients without traditional cardiovascular risks factors. Caffeine intake was evaluated with a 7-day food… Continue reading #Caffeine improves systemic #lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival
#Neuropsychiatric prodromes and symptom timings in relation to disease onset and/or flares in #SLE: results from the mixed methods international INSPIRE study
BackgroundNeuropsychiatric symptoms in SLE and other systemic autoimmune rheumatic diseases (SARDs) are challenging to diagnose, attribute and manage. We investigated the timings of onset of a broad range of neuropsychiatric (NP) symptoms in relation to timing of SLE onset. In addition, we explored whether NP symptoms may be a prodrome to SARD onset and to… Continue reading #Neuropsychiatric prodromes and symptom timings in relation to disease onset and/or flares in #SLE: results from the mixed methods international INSPIRE study
#Gout risk in adults with pre-#diabetes initiating metformin
Objective Despite the strong association between gout and pre-diabetes, the role of metformin in gout among individuals with pre-diabetes remains uncertain. We compared the incidence rates of gout in adults with pre-diabetes starting metformin with those not using antidiabetic treatments.Methods We conducted a new-user, propensity score-matched cohort study using electronic health records from an academic health system… Continue reading #Gout risk in adults with pre-#diabetes initiating metformin
Association between #sinusitis and incident #rheumatic diseases: a population-based study
To determine whether antecedent sinusitis is associated with incident rheumatic disease.Methods This population-based case–control study included all individuals meeting classification criteria for rheumatic diseases between 1995 and 2014. We matched three controls to each case on age, sex and length of prior electronic health record history. The primary exposure was presence of sinusitis, ascertained by diagnosis… Continue reading Association between #sinusitis and incident #rheumatic diseases: a population-based study
Vitamin #D and Marine n-3 #Fatty Acids for #Autoimmune Disease Prevention: Outcomes at Two Years after VITAL Trial Completion
ObjectiveIn the 5.3 year randomized, 2 x 2 factorial, double-blind, placebo-controlled VITamin D and OmegA-3 TriaL (VITAL), vitamin D supplementationreduced autoimmune disease (AD) incidence (hazard ratio [HR] 0.78, 95% confidence interval 0.61-0.99). Omega-3(n-3) fatty acid supplementation showed a statistically non-significant reduction (HR 0.85, 0.67-1.08). We aimed to confirm further AD cases arising during and after randomization and… Continue reading Vitamin #D and Marine n-3 #Fatty Acids for #Autoimmune Disease Prevention: Outcomes at Two Years after VITAL Trial Completion
#Ginger intake suppresses neutrophil extracellular trap formation in #autoimmune mice and healthy humans
We previously reported that treatment of mice with 6-gingerol, the most abundant phytochemical in ginger root, leads to phosphodiesterase inhibition that counteracts neutrophil hyperactivity in models of antiphospholipid syndrome (APS) and lupus. Here, we explored the extent to which oral intake of a whole-ginger extract would similarly impact neutrophils in both autoimmune mice and healthy… Continue reading #Ginger intake suppresses neutrophil extracellular trap formation in #autoimmune mice and healthy humans
Polycyclic aromatic hydrocarbons and risk of rheumatoid arthritis: a cross-sectional analysis of the National Health and Nutrition Examination Survey, 2007–2016
AbstractObjective While there are several well-established environmental risk factors for rheumatoid arthritis (RA), a paucity of evidence exists linking environmental toxicants with RA prevalence. We aimed to examine the associations between various environmental toxicants and RA among adults in the U.S. general population while adjusting for non-heritable risk factors.Design Cross-sectional study.Setting National Health and Nutrition Examination Survey conducted… Continue reading Polycyclic aromatic hydrocarbons and risk of rheumatoid arthritis: a cross-sectional analysis of the National Health and Nutrition Examination Survey, 2007–2016
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis. Here, we performed paired analysis of human and bacterial transcriptomics in longitudinal blood samples from RA patients. We found that patients with RA and periodontal disease experienced repeated oral bacteremias… Continue reading Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis
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