Guidelines recommend initiating anticoagulation within 4 to 14 days after cardioembolic stroke. Data supporting this did not account for key factors potentially affecting the decision to initiate anticoagulation, such as infarct size, hemorrhagic transformation, or high‐risk features on echocardiography.. ..We pooled data from stroke registries of 8 comprehensive stroke centers across the United States. We included… Continue reading #Anticoagulation Timing in Cardioembolic #Stroke and Recurrent Event Risk
Category: Neurology
Transcriptomic and clonal characterization of #T cells in the human central #nervous system
T cells provide critical immune surveillance to the central nervous system (CNS), and the cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further characterization of the state of T cells in the CSF in healthy individuals is important for understanding how T cells provide protective immune surveillance without damaging the… Continue reading Transcriptomic and clonal characterization of #T cells in the human central #nervous system
Increased risk of acute #stroke among patients with severe #COVID‐19: a multicenter study and meta‐analysis
Recent observations linked coronavirus disease 2019 (COVID‐19) to thromboembolic complications possibly mediated by increased blood coagulability and inflammatory endothelial impairment. We aimed to define the risk of acute stroke in patients with severe and non‐severe COVID‐19.. ..Of 165 patients hospitalized for COVID‐19 (49.1% males, median age 67 [57‐79], 72.1% severe or critical) included in the… Continue reading Increased risk of acute #stroke among patients with severe #COVID‐19: a multicenter study and meta‐analysis
Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for #heroin use disorder
The current opioid epidemic necessitates a better understanding of human addiction neurobiology to develop efficacious treatment approaches. Here, we perform genome-wide assessment of chromatin accessibility of the human striatum in heroin users and matched controls. Our study reveals distinct neuronal and non-neuronal epigenetic signatures, and identifies a locus in the proximity of the gene encoding… Continue reading Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for #heroin use disorder
Associations of #BMI and Serum #Urate with Developing #Dementia: A Prospective Cohort Study
Recent studies suggested that higher BMI and serum urate levels were associated with lower risk of developing dementia. However, these reverse relationships remain controversial, and whether serum urate and BMI confound each other is not well established.. ..During a median of 8.1 years of follow-up, a total of 2138 participants developed dementia. People who were… Continue reading Associations of #BMI and Serum #Urate with Developing #Dementia: A Prospective Cohort Study
Post-traumatic stress disorder as a risk factor for #dementia: systematic review and meta-analysis
Post-traumatic stress disorder (PTSD) has been identified as a potential risk factor for developing dementia. There are currently, however, no meta-analyses quantifying this risk.. ..PTSD was associated with a significant risk for all-cause dementia: pooled hazard ratio HR = 1.61 (95% CI 1.43–1.81, I2= 85.8%, P < 0.001; n = 1 693 678; 8 studies).… Continue reading Post-traumatic stress disorder as a risk factor for #dementia: systematic review and meta-analysis
An atlas on risk factors for type 2 #diabetes: a wide-angled Mendelian randomisation study
..We found evidence of causal associations between 34 exposures (19 risk factors and 15 protective factors) and type 2 diabetes. Insomnia was identified as a novel risk factor (OR 1.17 [95% CI 1.11, 1.23]). The other 18 risk factors were depression, systolic BP, smoking initiation, lifetime smoking, coffee (caffeine) consumption, plasma isoleucine, valine and leucine,… Continue reading An atlas on risk factors for type 2 #diabetes: a wide-angled Mendelian randomisation study
Estimates of the Association of #Dementia With US #Mortality Levels Using Linked Survey and Mortality Records
..Of the 7342 total sample, 4348 participants (60.3%) were women. At baseline, 4533 individuals (64.0%) were between ages 70 and 79 years, 2393 individuals (31.0%) were between 80 and 89 years, and 416 individuals (5.0%) were between 90 and 99 years; percentages were weighted. The percentage of deaths attributable to dementia was 13.6% (95% CI,… Continue reading Estimates of the Association of #Dementia With US #Mortality Levels Using Linked Survey and Mortality Records
Plasma Biomarker Concentrations Associated With Return to #Sport Following Sport-Related #Concussion in Collegiate Athletes—A Concussion Assessment, Research, and Education (CARE) Consortium Study
Identifying plasma biomarkers associated with the amount of time an athlete may need before they return to sport (RTS) following a sport-related concussion (SRC) is important because it may help to improve the health and safety of athletes.. A total of 3 plasma biomarkers (ie, total tau protein, glial fibrillary acidic protein [GFAP], and neurofilament… Continue reading Plasma Biomarker Concentrations Associated With Return to #Sport Following Sport-Related #Concussion in Collegiate Athletes—A Concussion Assessment, Research, and Education (CARE) Consortium Study
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