Stroke is a leading cause of death and disability and there is a need to identify modifiable risk factors. ObjectiveDetermine the relationship between thyroid hormone treatment intensity and incidence of atrial fibrillation and stroke. DesignRetrospective cohort study using data from the Veterans Health Administration between 2004 and 2017, with a median follow-up of 59 months.… Continue reading #Thyroid Hormone Therapy and Incident #Stroke
Category: Neurology
Effect of #bariatric surgery on ischemic #stroke risk
Bariatric surgery has demonstrated improvements in cardiovascular health. The effect on ischemic stroke risk remains unclear. The goal of this study was to compare the risk of stroke among bariatric surgery patients versus controls. MethodsUsing Mariner, a national all-payer claims database, we identified patients with BMI > 40, or BMI > 35 with qualifying comorbidities… Continue reading Effect of #bariatric surgery on ischemic #stroke risk
Factors associated with #eating performance in older adults with #dementia in long-term care facilities: a cross-sectional study
The purpose of this study was to investigate factors influencing eating performance in older adults with dementia (OAWDs) in long-term care (LTC) facilities. MethodsThis cross-sectional study examined risk factors for compromised eating performance by comparing both independent and dependent older adults with dementia. The study participants were 117 OAWDs in LTC facilities in South Korea.… Continue reading Factors associated with #eating performance in older adults with #dementia in long-term care facilities: a cross-sectional study
Reduced adaptation of glutamatergic #stress response is associated with #pessimistic expectations in #depression
Stress is a significant risk factor for the development of major depressive disorder (MDD), yet the underlying mechanisms remain unclear. Preclinically, adaptive and maladaptive stress-induced changes in glutamatergic function have been observed in the medial prefrontal cortex (mPFC). Here, we examine stress-induced changes in human mPFC glutamate using magnetic resonance spectroscopy (MRS) in two healthy… Continue reading Reduced adaptation of glutamatergic #stress response is associated with #pessimistic expectations in #depression
Number of #teeth and masticatory function are associated with #sarcopenia and #diabetes mellitus status among community-dwelling older adults: A Shimane CoHRE study
We aimed to examine the number of teeth and masticatory function as oral health indices and clarify their roles in the pathogenesis of sarcopenia and diabetes mellitus in community-dwelling older adults. Subjects and methodsThis cross-sectional study was conducted with 635 older adults in Ohnan, Shimane Prefecture, in rural Japan. The number of teeth and masticatory… Continue reading Number of #teeth and masticatory function are associated with #sarcopenia and #diabetes mellitus status among community-dwelling older adults: A Shimane CoHRE study
Consolidation of human #skill linked to waking hippocampo-neocortical replay
The introduction of rest intervals interspersed with practice strengthens wakeful consolidation of skill. The mechanisms by which the brain binds discrete action representations into consolidated, highly temporally-resolved skill sequences during waking rest are not known. To address this question, we recorded magnetoencephalography (MEG) during acquisition and rapid consolidation of a sequential motor skill. We report… Continue reading Consolidation of human #skill linked to waking hippocampo-neocortical replay
Reduced coupling between cerebrospinal fluid flow and global #brain activity is linked to #Alzheimer disease–related pathology
The glymphatic system plays an important role in clearing the amyloid-β (Aβ) and tau proteins that are closely linked to Alzheimer disease (AD) pathology. Glymphatic clearance, as well as Aβ accumulation, is highly dependent on sleep, but the sleep-dependent driving forces behind cerebrospinal fluid (CSF) movements essential to the glymphatic flux remain largely unclear. Recent… Continue reading Reduced coupling between cerebrospinal fluid flow and global #brain activity is linked to #Alzheimer disease–related pathology
A multicentre validation study of the diagnostic value of plasma #neurofilament light
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King’s College London (n = 805) and the Swedish BioFINDER study (n = 1,464). Plasma… Continue reading A multicentre validation study of the diagnostic value of plasma #neurofilament light
Predicting #language treatment response in bilingual #aphasia using neural network-based patient models
Predicting language therapy outcomes in bilinguals with aphasia (BWA) remains challenging due to the multiple pre- and poststroke factors that determine the deficits and recovery of their two languages. Computational models that simulate language impairment and treatment outcomes in BWA can help predict therapy response and identify the optimal language for treatment. Here we used… Continue reading Predicting #language treatment response in bilingual #aphasia using neural network-based patient models
2 Medical News 