IntroductionWe investigated associations of obesity with the expression of Alzheimer's disease (AD)–related genes in a large community-based cohort.MethodsThe sample consisted of 5619 participants from the Framingham Heart Study. Obesity metrics included body mass index (BMI) and waist-to-hip ratio (WHR). Gene expression was measured for a set of 74 AD-related genes, derived by integrating genome-wide association… Continue reading Obesity impacts the expression of Alzheimer’s disease–related genes: The Framingham Heart Study
Category: Neurology
Association between insomnia and the incidence of myocardial infarction: A systematic review and meta-analysis
BackgroundInsomnia has been closely associated with cardiovascular disease (CVD) including myocardial infarction (MI). Our study aims to assess the eligibility of insomnia as a potential risk factor for MI.MethodsPubMed, Scopus, and Web of Science were searched using terms; such as “Insomnia” and “MI.” Only observational controlled studies with data on the incidence of MI among… Continue reading Association between insomnia and the incidence of myocardial infarction: A systematic review and meta-analysis
Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
PurposeTo examine the association between dietary magnesium (Mg) intake and brain volumes and white matter lesions (WMLs) in middle to early old age.MethodsParticipants (aged 40–73 years) from UK Biobank (n = 6001) were included and stratified by sex. Dietary Mg was measured using an online computerised 24 h recall questionnaire to estimate daily Mg intake. Latent class… Continue reading Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
Examining understandability, information quality, and presence of misinformation in popular YouTube videos on sleep compared to expert-led videos
The Internet is a common source of sleep information, but may be subject to commercial bias and misinformation. We compared the understandability, information quality, and presence of misinformation of popular YouTube videos on sleep to videos with credible experts. We identified the most popular YouTube videos on sleep/insomnia and 5 videos from experts. Videos were… Continue reading Examining understandability, information quality, and presence of misinformation in popular YouTube videos on sleep compared to expert-led videos
Food Insufficiency, Supplemental Nutrition Assistance Program (SNAP) Status, and 9-Year Trajectory of Cognitive Function in Older Adults: The Longitudinal National Health and Aging Trends Study, 2012–2020
BackgroundDespite findings from cross-sectional studies, how food insecurity experience/Supplemental Nutrition Assistance Program (SNAP) status relates to cognitive decline over time has not been fully understood.ObjectivesWe aimed to investigate the longitudinal associations between food insecurity/SNAP status and cognitive function in older adults (≥65 y).MethodsLongitudinal data from the National Health and Aging Trends Study 2012–2020 were analyzed… Continue reading Food Insufficiency, Supplemental Nutrition Assistance Program (SNAP) Status, and 9-Year Trajectory of Cognitive Function in Older Adults: The Longitudinal National Health and Aging Trends Study, 2012–2020
Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool
Misfolded and aggregated α-synuclein is a neuropathological hallmark of Parkinson’s disease (PD). Thus, α-synuclein aggregates are regarded as a biomarker for the development of diagnostic assays. Quantification of α-synuclein aggregates in body fluids is challenging, and requires highly sensitive and specific assays. Recent studies suggest that α-synuclein aggregates may be shed into stool. We used… Continue reading Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool
Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke
Background and objectives: Previous studies have reported the protective effect of pioglitazone on dementia in type 2 diabetic mellitus (DM) patients. Recent studies have shown that pioglitazone also lowers the risk of primary and recurrent stroke. Understanding the characteristics of patients particularly associated with the benefits of pioglitazone would facilitate its personalized use by specifying… Continue reading Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke
Endovascular Therapy for Acute Stroke with a Large Ischemic Region
Endovascular therapy for acute ischemic stroke is generally avoided when the infarction is large, but the effect of endovascular therapy with medical care as compared with medical care alone for large strokes has not been well studied. We conducted a multicenter, open-label, randomized clinical trial in Japan involving patients with occlusion of large cerebral vessels… Continue reading Endovascular Therapy for Acute Stroke with a Large Ischemic Region
Cinnamon and cognitive function: a systematic review of preclinical and clinical studies
Cinnamon is the inner bark of trees named Cinnamomum. Studies have shown that cinnamon and its bioactive compounds can influence brain function and affect behavioral characteristics. This study aimed to systematically review studies about the relationship between cinnamon and its key components in memory and learning. Two thousand six hundred five studies were collected from… Continue reading Cinnamon and cognitive function: a systematic review of preclinical and clinical studies
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