Severe COVID-19 can manifest in rapid decompensation and respiratory failure with elevated inflammatory markers, consistent with cytokine release syndrome for which IL-6 blockade is approved treatment We assessed effectiveness and safety of IL-6 blockade with tocilizumab in a single-center cohort of patients with COVID-19 requiring mechanical ventilation. The primary endpoint was survival probability post-intubation; secondary… Continue reading #Tocilizumab for treatment of mechanically ventilated patients with #COVID-19
Category: Infectivology
#Dexamethasone in Hospitalized Patients with #Covid-19 — Preliminary Report
Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death In this controlled, open-label trial comparing a range of possible treatments in patients who were hospitalized with Covid-19, we randomly assigned patients to receive oral or intravenous dexamethasone (at a… Continue reading #Dexamethasone in Hospitalized Patients with #Covid-19 — Preliminary Report
#Probiotic Properties of #Escherichia coli Nissle in Human Intestinal Organoids
Probiotic, or beneficial, bacteria, such as E. coli Nissle, hold promise for the treatment of human disease. More study is needed to fully realize the potential of probiotics. Safety and efficacy studies are critically important; however, mice are poor models for many human intestinal diseases. We used stem cell-derived human intestinal organoid tissues to evaluate… Continue reading #Probiotic Properties of #Escherichia coli Nissle in Human Intestinal Organoids
Rapid Gel Card Agglutination Assays for Serological Analysis Following #SARS-CoV-2 Infection in Humans
High-throughput and rapid serology assays to detect the antibody response specific to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in human blood samples are urgently required to improve our understanding of the effects of COVID-19 across the world. Short-term applications include rapid case identification and contact tracing to limit viral spread, while population screening to determine the… Continue reading Rapid Gel Card Agglutination Assays for Serological Analysis Following #SARS-CoV-2 Infection in Humans
High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger #Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease
The clinical spectra of irritable bowel syndrome (#IBS) and inflammatory bowel disease (#IBD) intersect to form a scantily defined overlap syndrome, termed pre-IBD. We show that increased Enterobacteriaceae and reduced Clostridia abundance distinguish the fecal microbiota of pre-IBD patients from IBS patients. A history of antibiotics in individuals consuming a high-fat diet was associated with… Continue reading High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger #Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease
JOINT GUIDANCE ON VITAMIN D IN THE ERA OF COVID-19 FROM THE ASBMR, AACE, ENDOCRINE SOCIETY, ECTS, NOF, AND IOF
In response to the current COVID-19 global pandemic, and the attendant impact on outdoor physical activity and leisure time, the American Society for Bone and Mineral Research (ASBMR), American Association of Clinical Endocrinologists (AACE), Endocrine Society, European Calcified Tissue Society (ECTS), National Osteoporosis Foundation (NOF), and International Osteoporosis Foundation (IOF) remind individuals of the importance… Continue reading JOINT GUIDANCE ON VITAMIN D IN THE ERA OF COVID-19 FROM THE ASBMR, AACE, ENDOCRINE SOCIETY, ECTS, NOF, AND IOF
Reservoirs of antimicrobial resistance genes in retail raw milk
Background It has been estimated that at least 3% of the USA population consumes unpasteurized (raw) milk from animal sources, and the demand to legalize raw milk sales continues to increase. However, consumption of raw milk can cause foodborne illness and be a source of bacteria containing transferrable antimicrobial resistance genes (ARGs). To obtain a… Continue reading Reservoirs of antimicrobial resistance genes in retail raw milk
Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts
Baloxavir marboxil (baloxavir) is a polymerase acidic protein (PA) endonuclease inhibitor with clinical efficacy in the treatment of uncomplicated influenza, including in outpatients at increased risk for complications. The postexposure prophylactic efficacy of baloxavir in the household setting is unclear.. ..A total of 752 household contacts of 545 index patients were randomly assigned to receive… Continue reading Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts
Reduction of secondary transmission of SARS-CoV-2 in households by face mask use, disinfection and social distancing: a cohort study in Beijing, China
Transmission of COVID-19 within families and close contacts accounts for the majority of epidemic growth. Community mask wearing, hand washing and social distancing are thought to be effective but there is little evidence to inform or support community members on COVID-19 risk reduction within families.. ..The secondary attack rate in families was 23.0% (77/335). Face… Continue reading Reduction of secondary transmission of SARS-CoV-2 in households by face mask use, disinfection and social distancing: a cohort study in Beijing, China
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