..The linked systematic review and network meta-analysis (6 trials and 6059 participants) found that hydroxychloroquine had a small or no effect on mortality and admission to hospital (high certainty evidence). There was a small or no effect on laboratory confirmed SARS-CoV-2 infection (moderate certainty evidence) but probably increased adverse events leading to discontinuation (moderate certainty… Continue reading A living WHO guideline on drugs to prevent #covid-19
Category: Infectivology
Adherent-invasive E. coli metabolism of propanediol in #Crohn’s disease regulates phagocytes to drive intestinal #inflammation
Adherent-invasive E. coli (AIEC) are enriched in the intestinal microbiota of patients with Crohn’s disease (CD) and promote intestinal inflammation. Yet, how AIEC metabolism of nutrients impacts intestinal homeostasis is poorly defined. Here, we show that AIEC encoding the large subunit of propanediol dehydratase (PduC), which facilitates the utilization of fucose fermentation product 1,2-propanediol, are… Continue reading Adherent-invasive E. coli metabolism of propanediol in #Crohn’s disease regulates phagocytes to drive intestinal #inflammation
Early initiation of prophylactic #anticoagulation for prevention of #coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study
To evaluate whether early initiation of prophylactic anticoagulation compared with no anticoagulation was associated with decreased risk of death among patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United States. Design Observational cohort study. Setting Nationwide cohort of patients receiving care in the Department of Veterans Affairs, a large integrated national healthcare… Continue reading Early initiation of prophylactic #anticoagulation for prevention of #coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study
#Hydrating the respiratory tract: an alternative explanation why masks lower severity of #COVID-19
The seasonality of respiratory diseases has been linked, among other factors, to low outdoor absolute humidity and low indoor relative humidity, which increase evaporation of water in the mucosal lining of the respiratory tract. We demonstrate that normal breathing results in an absorption-desorption cycle inside facemasks, in which supersaturated air is absorbed by the mask… Continue reading #Hydrating the respiratory tract: an alternative explanation why masks lower severity of #COVID-19
Post-traumatic growth during the #COVID-19 pandemic in carers of children in Portugal and the UK: cross-sectional online survey
Although the negative effects of the COVID-19 pandemic on mental health have attracted interest, little attention has focused on its positive effects and possible post-traumatic growth. Aims To assess anxiety, well-being and post-traumatic growth in carers of children aged 6–16 years in Portugal and the UK. Method A cross-sectional online survey of volunteers conducted at… Continue reading Post-traumatic growth during the #COVID-19 pandemic in carers of children in Portugal and the UK: cross-sectional online survey
#mRNA vaccine-elicited antibodies to #SARS-CoV-2 and circulating variants
Here we report on the antibody and memory B cell responses in a cohort of 20 volunteers who received either the Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) vaccines1–4. Eight weeks after the second vaccine injection volunteers showed high levels of IgM, and IgG anti-SARS-CoV-2 spike protein (S) and receptor binding domain (RBD) binding titers. Moreover, the… Continue reading #mRNA vaccine-elicited antibodies to #SARS-CoV-2 and circulating variants
#SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801
All known recently emerged human coronaviruses probably originated in bats1. Here we used a single experimental platform based on human lung-only mice (LoM) to demonstrate efficient in vivo replication of all recently emerged human coronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2) and two highly relevant endogenous pre-pandemic SARS-like bat coronaviruses. Virus replication in this model occurs in… Continue reading #SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801
Quantifying asymptomatic infection and transmission of #COVID-19 in New York City using observed cases, serology, and testing capacity
The contributions of asymptomatic infections to herd immunity and community transmission are key to the resurgence and control of COVID-19, but are difficult to estimate using current models that ignore changes in testing capacity. Using a model that incorporates daily testing information fit to the case and serology data from New York City, we show… Continue reading Quantifying asymptomatic infection and transmission of #COVID-19 in New York City using observed cases, serology, and testing capacity
Decline in Covid-19 Hospitalisation Growth Associated With Statewide Mask Mandates
What is already known about this topic? Wearing masks is recommended to mitigate the spread of COVID-19. What is added by this report? During March 22–October 17, 2020, 10 sites participating in the COVID-19–Associated Hospitalization Surveillance Network in states with statewide mask mandates reported a decline in weekly COVID-19–associated hospitalization growth rates by up to… Continue reading Decline in Covid-19 Hospitalisation Growth Associated With Statewide Mask Mandates
2 Medical News 